Drug General Information
Drug ID	D03VNZ
Former ID	DNC006229
Drug Name	Pyrrolo[3,4-e]indole-1,3(2H,6H)-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527871]
Structure		Download 2D MOL 3D MOL
Formula	C10H6N2O2
Canonical SMILES	C1=CC2=C(C=CN2)C3=C1C(=O)NC3=O
InChI	1S/C10H6N2O2/c13-9-6-1-2-7-5(3-4-11-7)8(6)10(14)12-9/h1-4,11H,(H,12,13,14)
InChIKey	KVIRPIKEFDXNQF-UHFFFAOYSA-N
PubChem Compound ID	44407700
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[527871]
KEGG Pathway	Base excision repair
	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 527871	Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.
Ref 527871	Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.

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