Drug Information

Drug General Information
Drug ID
D0GJ8U
Former ID
DNC005762
Drug Name
4-(4-Morpholin-4-yl-butyl)-2H-phthalazin-1-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527682]
Structure
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2D MOL

3D MOL
Formula
C16H21N3O2
Canonical SMILES
C1COCCN1CCCCC2=NNC(=O)C3=CC=CC=C32
InChI
1S/C16H21N3O2/c20-16-14-6-2-1-5-13(14)15(17-18-16)7-3-4-8-19-9-11-21-12-10-19/h1-2,5-6H,3-4,7-12H2,(H,18,20)
InChIKey
BMGFFXOJQJDSQN-UHFFFAOYSA-N
PubChem Compound ID
44403404
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [527682]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527682Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5.4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.
Ref 527682Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5.4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.

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