Drug Information

Drug General Information
Drug ID
D0Q7UD
Former ID
DNC008718
Drug Name
ABT-888
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Phase 3 [524798], [542441]
Structure
Download
2D MOL

3D MOL
Formula
C13H16N4O
InChI
InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1
InChIKey
JNAHVYVRKWKWKQ-CYBMUJFWSA-N
PubChem Compound ID
11960529
PubChem Substance ID
17418828, 23919521, 36457782, 48431542, 53786540, 57298845, 78845658, 85742017, 93581011, 99432361, 99443703, 103628124, 123051081, 124490432, 124756927, 125163734, 126522682, 126626210, 126661310, 126665801, 126731194, 131271125, 131465098, 134223378, 134345923, 135251923, 136367452, 137275905, 137517732, 138192110, 152090859, 152258095, 152344520, 160646934, 160968315, 162011690, 162202719, 163776182, 163907937, 164041817, 164194024, 164339419, 174531428, 178103989, 184816212, 194943753, 198953538, 198994026, 208265497, 212343015
Target and Pathway
Target(s) Poly ADP ribose polymerase (PARP) Target Info Modulator [1572591]
References
Ref 524798ClinicalTrials.gov (NCT02163694) A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer. U.S. National Institutes of Health.
Ref 542441(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7417).
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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