Drug General Information
Drug ID	D0M6WJ
Former ID	DNC009395
Drug Name	Benzo[c][1,5]naphthyridin-6(5H)-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529901]
Structure		Download 2D MOL 3D MOL
Formula	C12H8N2O
Canonical SMILES	C1=CC=C2C(=C1)C3=C(C=CC=N3)NC2=O
InChI	1S/C12H8N2O/c15-12-9-5-2-1-4-8(9)11-10(14-12)6-3-7-13-11/h1-7H,(H,14,15)
InChIKey	NGHUYPCHBUPCNK-UHFFFAOYSA-N
PubChem Compound ID	10535869
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[529901]
KEGG Pathway	Base excision repair
	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 529901	J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.
Ref 529901	J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.

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