Drug Information

Drug General Information
Drug ID
D0FF4M
Former ID
DNC009393
Drug Name
1,2,3,4,4a,5-hexahydrophenanthridin-6(10bH)-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529901]
Structure
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2D MOL

3D MOL
Formula
C13H15NO
Canonical SMILES
C1CCC2C(C1)C3=CC=CC=C3C(=O)N2
InChI
1S/C13H15NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-2,5,7,10,12H,3-4,6,8H2,(H,14,15)
InChIKey
CQQBPJQEIHYWQX-UHFFFAOYSA-N
PubChem Compound ID
345678
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [529901]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 529901J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.
Ref 529901J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.

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