Drug General Information
Drug ID
D01SHZ
Former ID
DNCL002606
Drug Name
Rucaparib
Drug Type
Small molecular drug
Indication BRCA-positive ovarian cancer [ICD10:C56] Approved [889440]
Breast cancer; Ovarian cancer [ICD9: 174, 175, 183; ICD10:C50, C56] Phase 3 [524484], [542704]
Company
Clovis Oncology
Structure
Download
2D MOL

3D MOL

Formula
C19H18FN3O
InChI
InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)
InChIKey
HMABYWSNWIZPAG-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Poly ADP ribose polymerase (PARP) Target Info Modulator [889440]
References
Ref 524484ClinicalTrials.gov (NCT01968213) A Study of Rucaparib as Switch Maintenance Following Platinum-Based Chemotherapy in Patients With Platinum-Sensitive, High-Grade Serous or Endometrioid Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancer. U.S. National Institutes of Health.
Ref 542704(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7736).
Ref 8894402016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.
Ref 8894402016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.

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