Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 1-{3-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carbonyl]-piperidin-1-yl}-ethanone | Drug Info |
| Ftase --- FPTase | 4-((5-(((3-aminopropyl)(1-(3-chlorobenzyl)-2-oxopyrrolidin-3-yl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 2-(4-Benzyloxy-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(4-Methoxy-benzylsulfanyl)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-(3-methyl-3H-imidazole-4-carbonyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 2-Phosphonomethyl-N-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-malonamic acid | Drug Info |
| Ftase --- FPTase | 2-{[1-(2-Amino-3-mercapto-propionyl)-piperidin-4-yl]-benzoyl-amino}-4-methylsulfanyl-butyric acid methyl ester; hydrochloride | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[((S)-2-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetylamino}-3-methyl-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-4-methylsulfanyl-butyramide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((S)-3,7-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | (4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid benzylamide | Drug Info |
| Ftase --- FPTase | N-(4H-Benzo[1,3]dioxin-6-yl)-4-(3-bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | (R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-[2-(4-chloro-phenyl)-acetyl]-piperazine-2-carboxylic acid methylamide | Drug Info |
| Ftase --- FPTase | 6-[(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3'-methoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propylamino)-3-methyl-butyryl]-1,2,3,6-tetrahydro-pyridine-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 2-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-isoindole-1,3-dione | Drug Info |
| Ftase --- FPTase | (R)-2-[(R)-2-((S)-2-Benzyl-3-phosphono-propionylamino)-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| Ftase --- FPTase | 1-[4-((S)-3-Bromo-8-chloro-10-fluoro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-quinolin-8-yl-benzonitrile | Drug Info |
| Ftase --- FPTase | 6-(((6-cyano-2'-(trifluoromethyl)biphenyl-3-yl)(1-methyl-1H-imidazol-5-yl)methoxy)methyl)-2-((tetrahydrofuran-2-yl)methylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 1-{2-[3-(4-Cyano-3-naphthalen-1-yl-benzyl)-3H-imidazol-4-yl]-acetyl}-5-methoxy-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-((1H-imidazol-1-yl)methyl)-2-(2,3-dimethoxyphenoxy)benzonitrile | Drug Info |
| Ftase --- FPTase | [1-(3-Methyl-3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-morpholin-4-yl-methanone | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Methyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-5-Bromo-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 4'-(2-Amino-3-mercapto-propylamino)-[1,1';2',1'']terphenyl-3-carboxylic acid 14 (FTI-289) | Drug Info |
| Ftase --- FPTase | N-(2-Cyano-ethyl)-N-cyclopropyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methylamide | Drug Info |
| Ftase --- FPTase | 2-(3-Cyano-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-bromo-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | [(R)-1-[(R)-1-{(S)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-benzyloxy-phenyl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(4-pentyl-phenyl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile | Drug Info |
| Ftase --- FPTase | N-(adamantan-2-yl)-10-cyano-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.1^{3,7}.1^{9,13}.0^{15,19}]heptacosa-3(27),4,6,9(26),10,12,16,18-octaene-4-carboxamide | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-[3-(1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(2-cyclohexylethyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | 6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-4'-methoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-({3-(2-Chloro-3-hydroxy-4-methoxy-phenyl)-2-[((R)-3-(4-hydroxy-phenyl)-2-{(E)-3-[((Z)-2-pent-1-enyl)-phenyl]-acryloylamino}-propionyl)-methyl-amino]-propionyl}-methyl-amino)-3-phenyl-propionic acid (S)-3,6-dioxo-piperazin-2-ylmethyl ester | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-dimethylamino-butyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-2'-methoxy-biphenyl-3-carboxylic acid | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| Ftase --- FPTase | 4-{2-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-butyl-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[(E)-4-(Hydroxy-diphenyl-methyl)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 2-(4-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({Butyl-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
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