Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 8-Chloro-7-((2R,3R)-6-chloro-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b]thiophen-3-yloxymethyl)-[1,3]dioxolo[4,5-g]quinoline | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[(1H-Imidazol-4-ylmethyl)-amino]-3',5'-dimethyl-biphenyl-2-carbonyl}-amino)-4-methyl-pentanoic acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(2-ethoxy-acetyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-quinolin-8-yl-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl)-4-phenyl-piperidine-4-carbonyl]-amino}-4-methyl-pentanoylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-[3-(3-cyclopropylmethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-3-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-3-yl)-ethanone | Drug Info |
| Ftase --- FPTase | N-(6-cyano-1-((1-methyl-1H-imidazol-5-yl)methyl)-1,2,3,4-tetrahydroquinolin-3-yl)-1-methyl-N-phenethyl-1H-imidazole-4-sulfonamide | Drug Info |
| Ftase --- FPTase | (S)-4-((5-(2-(1-benzyl-2-oxopyrrolidin-3-ylamino)ethyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-naphthalen-1-yl-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-naphthalen-1-ylmethyl-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 2-{2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-isoindole-1,3-dione | Drug Info |
| Ftase --- FPTase | 5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carbonyl)-nicotinic acid | Drug Info |
| Ftase --- FPTase | 2-({2-[(2-Mercapto-ethylcarbamoyl)-methyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-7-Chloro-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-methanesulfonyl-piperidin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 8-Chloro-11-(1-(propylsulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-naphthalen-2-ylmethyl-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | N-Dodecyl-2-phosphonomethyl-malonamic acid | Drug Info |
| Ftase --- FPTase | N-(6-cyano-1-((1-methyl-1H-imidazol-5-yl)methyl)-1,2,3,4-tetrahydroquinolin-3-yl)-1-methyl-N-(2-methylallyl)-1H-imidazole-4-sulfonamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-benzyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 3-{[[3-(3,4-Dihydro-2H-quinoline-1-sulfonyl)-phenyl]-(3H-imidazol-4-ylmethyl)-amino]-methyl}-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-{3-[((R)-2-Amino-3-mercapto-propylamino)-methyl]-benzoylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid methyl ester 29 (FTI-2310) | Drug Info |
| Ftase --- FPTase | 8-hydroxy-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8S,9S,13S)-11-azatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6-triene-9-carboxylic acid (RPR114235) | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-sulfonylmethyl]-7,7-dimethyl-bicyclo[2.2.1]heptan-2-ol | Drug Info |
| Ftase --- FPTase | 4-({[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-piperidine-1-carboximidoyl]-amino}-methyl)-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-{[2-(1H-imidazol-4-yl)-ethyl]-amide} | Drug Info |
| Ftase --- FPTase | 6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-4-one | Drug Info |
| Ftase --- FPTase | 1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-1-methyl-1H-quinolin-2-one | Drug Info |
| Ftase --- FPTase | 16-ethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-methoxy-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-methyl-piperidin-4-yl)-amide | Drug Info |
| Ftase --- FPTase | 2-(3-Ethynyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carbonyl)-nicotinamide | Drug Info |
| Ftase --- FPTase | 2-[2-(2-Chloro-phenyl)-1H-indol-3-yl]-N-isopropyl-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | 2-(2,5-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | Sodium salt of 2-Phosphonooxymethyl-N-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-malonamic acid | Drug Info |
| Ftase --- FPTase | (S)-4-((5-((2-oxo-1-phenethylpyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-isopropyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-5H-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-difluoro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyclohexyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 3-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methyl ester | Drug Info |
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