Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | N-sec-Butyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-ylamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(2-Ethylsulfanyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-methoxy-propionyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-2-[1,2,4]triazol-1-yl-ethanone | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-methyl-piperidin-3-yl)-amide | Drug Info |
| Ftase --- FPTase | 1-[2-(4-Cyano-phenyl)-2-hydroxy-2-(3-methyl-3H-imidazol-4-yl)-ethyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 4-(1-Carboxy-3-methylsulfanyl-propylcarbamoyl)-5-o-tolyl-3,6-dihydro-2H-pyridine-1-carboxylic acid 3-cyclohexyl-1-thiazol-5-yl-propyl ester | Drug Info |
| Ftase --- FPTase | 3-(2-Cyano-5-imidazol-1-ylmethyl-phenoxy)-N-phenyl-benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-(5-((R)-2-amino-3-mercaptopropylamino)biphenyl-2-ylcarboxamido)-4-methylpentanoic acid | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{Benzyl-[(S)-2-(3-mercapto-propylamino)-3-methyl-pentyl]-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-[(3'-methoxy-5-nitro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | [4-Anthracen-9-yl-1-(3H-imidazol-4-ylmethyl)-1H-pyrrol-3-yl]-p-tolyl-methanone | Drug Info |
| Ftase --- FPTase | (S)-2-[(2'-Methyl-5-pyrimidin-5-ylethynyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,4-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-({2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-indane-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-((5-((1-(4-chlorobenzyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-butyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-2-yl-ethanone | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-cyclopentanecarbonyl-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methoxymethyl-benzyl ester | Drug Info |
| Ftase --- FPTase | (S)-2-((R)-2-((S)-2-((R)-2-amino-3-mercaptopropanamido)-3-methylbutanamido)-3-(4-hydroxy-2,3-dimethylphenyl)propanamido)-4-(methylthio)butanoic acid | Drug Info |
| Ftase --- FPTase | 4-((5-((1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodecatriene1-diphosphate (3-tbFPP) | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-methanesulfonyl-phenyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(6-methyl-pyridin-3-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile | Drug Info |
| Ftase --- FPTase | 8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-6-(3-chloro-phenyl)-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({2'-methyl-5-[5-(4-methylsulfanyl-phenyl)-furan-2-ylmethoxymethyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| Ftase --- FPTase | 6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-3''-methoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-biphenyl-2-carboxylic acid benzylamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(2,3-dimethyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-(3,3-dimethyl-1-butynyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| Ftase --- FPTase | 2-Chloro-3-((2R,3R)-6-chloro-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b]thiophen-3-yloxymethyl)-pyridine | Drug Info |
| Ftase --- FPTase | 1-[4-((S)-3-Bromo-8,10-dichloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(2-chloro-benzo[b]thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | (R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol | Drug Info |
| Ftase --- FPTase | 6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-3'-(trifluoromethoxy)biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (2S)-2-(2-(3-(2-(1H-imidazol-5-yl)ethyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoic acid | Drug Info |
| Ftase --- FPTase | (2S)-2-(5-((1H-imidazol-4-yl)methylamino)-2'-methylbiphenyl-2-ylcarboxamido)-4-methylpentanoic acid | Drug Info |
| Ftase --- FPTase | (4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a]quinolin-7-yl)(1-methyl-1H-imidazol-5-yl)methanamine | Drug Info |
| Ftase --- FPTase | (R)-2-Amino-1-[4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-3-mercapto-propan-1-one | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-3-(3'-methoxy-5-pentanoyl-biphenyl-2-yl)-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile | Drug Info |
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