Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(2-chloro-benzo[b]thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | (R)-2-Amino-3-(biphenyl-4-ylamino)-propane-1-thiol | Drug Info |
| Ftase --- FPTase | 6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-3'-(trifluoromethoxy)biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (2S)-2-(2-(3-(2-(1H-imidazol-5-yl)ethyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoic acid | Drug Info |
| Ftase --- FPTase | (2S)-2-(5-((1H-imidazol-4-yl)methylamino)-2'-methylbiphenyl-2-ylcarboxamido)-4-methylpentanoic acid | Drug Info |
| Ftase --- FPTase | (4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a]quinolin-7-yl)(1-methyl-1H-imidazol-5-yl)methanamine | Drug Info |
| Ftase --- FPTase | (R)-2-Amino-1-[4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-3-mercapto-propan-1-one | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | 4-[1-Hydroxy-3-(3'-methoxy-5-pentanoyl-biphenyl-2-yl)-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(5-oxo-hexanoyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclopropylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-1H-quinolin-2-one | Drug Info |
| Ftase --- FPTase | 2-(3,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-5,7-Dichloro-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Nitro-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid 26 (FTI-2325) | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({(4-Cyano-benzyl)-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | R-Diastereomer A-2-(3-chlorophenyl)-27-oxo-20-oxa-3,7,11,13-tetraazapentacyclo[19.3.1.13,6.115,19.09,13]heptacosa-1(24),9,11,15(26),16,18,21(25),22-octaen-18-yl cyanide | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[((E)-2-quinolin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (E)-3-Biphenyl-4-yl-N-{2-[3-(2,3-dimethyl-phenylsulfamoyl)-phenylcarbamoyl]-ethyl}-acrylamide | Drug Info |
| Ftase --- FPTase | (S)-3-Hydroxy-2-[(S)-2-((S)-2-{2-[hydroxy-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-carbamoyl]-acetylamino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-propionic acid | Drug Info |
| Ftase --- FPTase | 2'',15''-dimethyl-5'',17''-dioxo-(2''R,5'R,15''S)-dispiro[dihydro[1,3]dioxolane-4,4'-(4'H-[1,3]dioxolane)-5',14''-tetracyclo[8.7.0.02,7.011,15]heptadeca-3'',6''-diene]-4''-carbaldehyde | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(2-Chloro-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[4-(4-nitro-phenyl)-butyrylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-(1-oxy-pyridin-3-yl)-propan-1-one | Drug Info |
| Ftase --- FPTase | (S)-2-{2-[((S)-2-{2-[3-(4-Methoxy-benzyl)-3H-imidazol-4-yl]-acetylamino}-3-methyl-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-2-((4E,8E)-2-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino)-3-phenyl-propionic acid | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| Ftase --- FPTase | N-[3-(2-Cyano-5-imidazol-1-ylmethyl-phenoxy)-phenyl]-benzamide | Drug Info |
| Ftase --- FPTase | 3-[(R)-3-(1,5-Dimethyl-hexyl)-3a-methyl-7-oxo-dodecahydro-cyclopenta[a]naphthalen-6-yl]-propionic acid | Drug Info |
| Ftase --- FPTase | [4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-quinolin-8-yl-methanone | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-methyl-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 1-Methyl-1H-pyrazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-thiophen-3-ylmethyl-amide | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(Pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-2-[3-(2-hydroxy-ethoxy)-phenoxy]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Chlorophenyl)-6-((4-chlorophenyl)(hydroxy)(1-ethyl-1H-imidazol-5-yl)methyl)-1-methylquinolin-2(1H)-one | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[2-((E)-5-phenyl-pyridin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-{5-[(2-Oxo-1-pyridin-2-yl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| Ftase --- FPTase | 2-{(R)-1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-carbonyl]-3-methylsulfanyl-propyl}-isoindole-1,3-dione | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-oxa-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-3'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 3-Benzyl-7-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-carboxylic acid dimethylamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-7-yl]-C-(3-methyl-3H-imidazol-4-yl)-methylamine | Drug Info |
| Ftase --- FPTase | 3-Carboxy-pentanedioic acid mono-{(E)-10-[(14E,18Z)-4-carboxy-19-(6-carboxy-4-ethyl-3-oxo-heptyl)-12-hydroxy-11,13,15,17-tetramethyl-2,6-dioxo-1,7dioxa-cycloicosa-14,18-dien-8-yl]-1,4-dimethyl-dec-5-enyl} ester | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyryl]-methyl-amino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 5-Benzo[1,3]dioxol-5-yl-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
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