Drug Information

Drug General Information
Drug ID
DX3ZBA
Drug Name
2-{(R)-1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-carbonyl]-3-methylsulfanyl-propyl}-isoindole-1,3-dione
Synonyms
CHEMBL318840
Indication Discovery agent Investigative [1587926]
Formula
C32H30ClN3O3S
Canonical SMILES
CSCC[C@@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCC(=C4c5ccc(Cl)cc5CCc6cccnc46)CC3
InChI
InChI=1S/C32H30ClN3O3S/c1-40-18-14-27(36-30(37)25-6-2-3-7-26(25)31(36)38)32(39)35-16-12-20(13-17-35)28-24-11-10-23(33)19-22(24)9-8-21-5-4-15-34-29(21)28/h2-7,10-11,15,19,27H,8-9,12-14,16-18H2,1H3/t27-/m1/s1
InChIKey
NSMCUXFIOPAIMK-HHHXNRCGSA-N
Target and Pathway
Target(s) Farnesyltransferase Target Info [1587926]
Protein farnesyltransferase beta subunit Target Info [1587926]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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