Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 2-(2,5-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | Sodium salt of 2-Phosphonooxymethyl-N-(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-malonamic acid | Drug Info |
| Ftase --- FPTase | (S)-4-((5-((2-oxo-1-phenethylpyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-isopropyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10,10-dioxo-10,11-dihydro-5H-10lambda*6*-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-difluoro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyclohexyl-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 3-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-hexanoic acid | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-[2-(2-methoxy-phenyl)-1H-indol-3-yl]-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-fluoro-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| Ftase --- FPTase | 1-[3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-ethanone | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-[3-(1,3-dimethyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalen-1-ylmethyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-(3-Benzo[1,3]dioxol-5-ylmethyl-3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrole-3-carboxylic acid (2-methoxy-ethyl)-methyl-amide | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-4-Benzoyl-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-morpholin-4-yl-methanone | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-(4-phenoxy-phenyl)-methanone | Drug Info |
| Ftase --- FPTase | (S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(5-chloro-benzo[1,3]dioxol-4-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-methyl-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-3-yl)-amide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-10-methyl-10,11-dihydro-5H-4,10-diaza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1H-quinolin-2-one | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-hexanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4'-tert-butyl-6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (20R)-19,20,21,22-Tetrahydro-5-methyl-19-oxo-17H-18,20-ethano-6,10:12,1 6-dimetheno-16H-imidazo-[3,4-h][1,8,11,14]oxatriazacycloeicosine-9-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-4-Methylsulfanyl-2-{2-[((S)-3-methyl-2-{2-[3-((2E,7E)-3,8,12-trimethyl-trideca-2,7,11-trienyl)-3H-imidazol-4-yl]-acetylamino}-pentyl)-naphthalen-1-ylmethyl-amino]-acetylamino}-butyric acid | Drug Info |
| Ftase --- FPTase | 1-(3H-Imidazol-4-ylmethyl)-4-(naphthalene-1-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| Ftase --- FPTase | (S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldisulfanyl-propionylamino)-methyl]-3-benzyloxy-tetrahydro-pyran-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-2-yl-1H-pyrrol-3-yl]-p-tolyl-methanone | Drug Info |
| Ftase --- FPTase | (S)-4-Methylsulfanyl-2-({5-[(1-naphthalen-1-ylmethyl-1H-imidazol-4-ylmethyl)-amino]-biphenyl-2-carbonyl}-amino)-butyric acid | Drug Info |
| Ftase --- FPTase | 1-{2-[Benzyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-[(5,3'-dichloro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-{5-[(S)-4-(3-Chloro-phenyl)-2-methyl-5-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid 24 (FTI-2312) | Drug Info |
| Ftase --- FPTase | 2-[3-(1-Acetyl-3-ethyl-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-4-Chloro-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-tert-butylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| Ftase --- FPTase | 4-[(5-chloro-3'-ethoxy-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methylamide | Drug Info |
| Ftase --- FPTase | 1-(3-Chloro-phenyl)-4-[3-(3-phenoxy-benzyl)-3H-imidazol-4-ylmethyl]-piperazin-2-one | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-3-methyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-naphthalen-1-yl-methanone | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | (+)1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-piperidin-4-ylmethyl-piperidine-1-carboxamidine | Drug Info |
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