Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- TEK | 7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | 5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| VEGFR2 --- TEK | SID124350135 | Drug Info |
| VEGFR2 --- TEK | 2-(2-(4-methyl-1-piperazino)ethylamino)-5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1Hbenzimidazole | Drug Info |
| VEGFR2 --- TEK | 3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-furo[3,2-c]pyridin-7-yl)-benzenesulfonamide | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| VEGFR2 --- TEK | CHEMBL499864 | Drug Info |
| VEGFR2 --- TEK | 5-(4-(dimethylamino)phenyl)-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((2,5-difluorophenyl)aminocarbonylamino)-phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| VEGFR2 --- TEK | 3-{3-butyl-19-methyl-14-oxo-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-(4-methoxyphenyl)urea | Drug Info |
| VEGFR2 --- TEK | (E/Z)-4-(2-(4-phenyl-1H-imidazol-5-yl)vinyl)pyrimidin-2-amine | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3-(2-methylpropyl)-7-[(1E)-1-[(propan-2-yloxy)imino]ethyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | 4-methoxyphenyl N-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}carbamate | Drug Info |
| VEGFR2 --- TEK | N-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}furan-2-carboxamide | Drug Info |
| VEGFR2 --- TEK | 4-methyl-N3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-5-yl)-N1-(3-(trifluoromethyl)phenyl)isophthalamide | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3-(propan-2-yl)-7-[(thiophen-2-yl)carbonyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | 7-acetyl-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | N-(2-methoxy-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)benzamide | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(ethoxyimino)ethyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | 7-[(3-chlorothiophen-2-yl)carbonyl]-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((2-fluoro-5-aminophenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| VEGFR2 --- TEK | N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)-2-(2-methoxyethoxy)-acetamide | Drug Info |
| VEGFR2 --- TEK | N3-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-N6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine | Drug Info |
| VEGFR2 --- TEK | N-(3-isopropylphenyl)-4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)benzamide | Drug Info |
| VEGFR2 --- TEK | 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}urea | Drug Info |
| VEGFR2 --- TEK | 5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| VEGFR2 --- TEK | N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethoxy)benzamide | Drug Info |
| VEGFR2 --- TEK | 3-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| VEGFR2 --- TEK | OSI-632 | Drug Info |
| VEGFR2 --- TEK | 7-Cyclopentyl-6-morpholin-4-ylmethyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| VEGFR2 --- TEK | SID124349821 | Drug Info |
| VEGFR2 --- TEK | N-(3-isopropylphenyl)-4-methyl-3-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)benzamide | Drug Info |
| VEGFR2 --- TEK | 3-(2-(3H-imidazo[4,5-b]pyridin-6-yl)ethynyl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide | Drug Info |
| VEGFR2 --- TEK | 1-(4-(4-amino-6-isopropylthieno[2,3-d]pyrimidin-5-yl)phenyl)-3-m-tolylurea | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(hydroxyimino)ethyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| VEGFR2 --- TEK | 9-cyclopentyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| VEGFR2 --- TEK | 5-(((3-fluoro-5-(trifluoromethyl)phenyl)carbonyl)amino)-2-methyl-N-(2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-5-pyrimidinyl)benzamide | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3-(propan-2-yl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | 7-tert-Butyl-5-[4-(4-methoxy-phenoxy)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((3-(trifluoromethylthio)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| VEGFR2 --- TEK | 7-amino-19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(4-methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)-3-pyridinecarboxamide | Drug Info |
| VEGFR2 --- TEK | rac-9-(2-ethoxyethyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| VEGFR2 --- TEK | N-(4-fluoro-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-isopropylbenzamide | Drug Info |
| VEGFR2 --- TEK | 19-methyl-7-[(thiophen-2-yl)carbonyl]-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | 7-[(1E)-1-(methoxyimino)-2-methylpropyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| VEGFR2 --- TEK | rac-9-(cyclohexylmethyl)-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
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