Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX0WEK
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| Drug Name |
5-(2-(2-aminopyrimidin-5-yl)ethynyl)-2-fluoro-N-(3-(trifluoromethyl)phenyl)benzamide
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| Synonyms |
CHEMBL218631
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C20H12F4N4O
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| Canonical SMILES |
Nc1ncc(cn1)C#Cc2ccc(F)c(c2)C(=O)Nc3cccc(c3)C(F)(F)F
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| InChI |
InChI=1S/C20H12F4N4O/c21-17-7-6-12(4-5-13-10-26-19(25)27-11-13)8-16(17)18(29)28-15-3-1-2-14(9-15)20(22,23)24/h1-3,6-11H,(H,28,29)(H2,25,26,27)
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| InChIKey |
YEVPZIUDTUZJGY-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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