Target Information

Target General Information

Top

Target ID

T67162 (Former ID: TTDS00012)

Target Name

Dopamine D2 receptor (D2R)

Synonyms

Dopamine receptor 2; D(2) dopamine receptor

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Gene Name

DRD2

Target Type

Successful target

[1]

Disease

[+] 33 Target-related Diseases

Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]

Alzheimer disease [ICD-11: 8A20]

Asthma [ICD-11: CA23]

Attention deficit hyperactivity disorder [ICD-11: 6A05]

Bipolar disorder [ICD-11: 6A60]

Breathing abnormality [ICD-11: MD11]

Cardiovascular disease [ICD-11: BA00-BE2Z]

Cerebral ischaemia [ICD-11: 8B1Z]

Depression [ICD-11: 6A70-6A7Z]

Digestive system disease [ICD-11: DE2Z]

Essential hypertension [ICD-11: BA00]

Faecal incontinence [ICD-11: ME07]

Gangrene [ICD-11: MC85]

Glaucoma [ICD-11: 9C61]

Heart failure [ICD-11: BD10-BD1Z]

Hyperaemia [ICD-11: 9A61-9B7Y]

Hypertension [ICD-11: BA00-BA04]

Hypotension [ICD-11: BA20-BA21]

Inborn porphyrin/heme metabolism error [ICD-11: 5C58]

Insomnia [ICD-11: 7A00-7A0Z]

Itching [ICD-11: 1F28-1G07]

Migraine [ICD-11: 8A80]

Nausea/vomiting [ICD-11: MD90]

Pain [ICD-11: MG30-MG3Z]

Parkinsonism [ICD-11: 8A00]

Pituitary gland disorder [ICD-11: 5A60-5A61]

Postpartum haemorrhage [ICD-11: JA43]

Psychotic disorder [ICD-11: 6A20-6A25]

Pulmonary hypertension [ICD-11: BB01]

Schizophrenia [ICD-11: 6A20]

Substance abuse [ICD-11: 6C40]

Thyrotoxicosis [ICD-11: 5A02]

Type 2 diabetes mellitus [ICD-11: 5A11]

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

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BioChemical Class

GPCR rhodopsin

UniProt ID

DRD2_HUMAN

Sequence

MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

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3D Structure

Click to Show 3D Structure of This Target

PDB

ADReCS ID

BADD_A03272 ; BADD_A04234

HIT2.0 ID

T48ZIG

Drugs and Modes of Action

Top

Approved Drug(s)

[+] 70 Approved Drugs

Acetophenazine

Drug Info

Approved

Bipolar disorder

[2], [3]

Amisulpride

Drug Info

Approved

Schizophrenia

[4], [5]

Aniracetam

Drug Info

Approved

Cerebrovascular ischaemia

[6], [7]

Apomorphine

Drug Info

Approved

Parkinson disease

[8], [9]

Aripiprazole

Drug Info

Approved

Schizophrenia

[10], [11]

Bevantolol

Drug Info

Approved

Hypertension

[3], [5]

Bromocriptine

Drug Info

Approved

Parkinson disease

[12], [13]

Cabergoline

Drug Info

Approved

Hyperprolactinaemia

[13], [14]

Cariprazine

Drug Info

Approved

Bipolar disorder

[15], [16]

Carphenazine

Drug Info

Approved

Insomnia

[3]

Chlorpromazine

Drug Info

Approved

Schizophrenia

[17], [18]

Chlorprothixene

Drug Info

Approved

Psychotic disorder

[19]

Dapiprazole

Drug Info

Approved

Glaucoma/ocular hypertension

[3]

Denopamine

Drug Info

Approved

Cardiac disease

[3], [20]

Dihydroergotamine

Drug Info

Approved

Migraine

[21]

Dihydroergotoxine

Drug Info

Approved

Alzheimer disease

[22]

Docarpamine

Drug Info

Approved

Hypertension

[3]

Domperidone

Drug Info

Approved

Gastrointestinal disease

[23], [24]

Dopamine

Drug Info

Approved

Parkinson disease

[25], [26]

Dopexamine

Drug Info

Approved

Cardiac failure

[3]

Droperidol

Drug Info

Approved

Nausea

[27], [28]

Ephedrine

Drug Info

Approved

Asthma

[29], [30]

Ergonovine

Drug Info

Approved

Postpartum haemorrhage

[31], [32]

Fluspirilene

Drug Info

Approved

Schizophrenia

[33], [34]

Haloperidol

Drug Info

Approved

Schizophrenia

[5], [35]

Ibopamine hci

Drug Info

Approved

Cardiac disease

[3]

Iloperidone

Drug Info

Approved

Schizophrenia

[36], [37]

Levodopa

Drug Info

Approved

Parkinson disease

[38]

Levomepromazine

Drug Info

Approved

Psychotic disorder

[3]

Lisuride

Drug Info

Approved

Parkinson disease

[39], [40]

Loxapine

Drug Info

Approved

Schizophrenia

[3]

lumateperone tosylate

Drug Info

Approved

Schizophrenia

[41]

Lurasidone hydrochloride

Drug Info

Approved

Schizophrenia

[3], [42], [43], [44]

Meglitinides

Drug Info

Approved

Type-2 diabetes

[45]

Mephentermine

Drug Info

Approved

High blood pressure

[3]

Mesoridazine

Drug Info

Approved

Schizophrenia

[46], [47]

Metaraminol

Drug Info

Approved

Hypotension

[48], [49]

Methamphetamine

Drug Info

Approved

Pain

[50]

Methyldopa

Drug Info

Approved

Hypertension

[51], [52]

Metoclopramide

Drug Info

Approved

Nausea

[53], [54]

Molindone

Drug Info

Approved

Schizophrenia

[55], [56]

N-0923

Drug Info

Approved

Parkinson disease

[57], [58]

Naphazoline

Drug Info

Approved

Itching

[3]

Nemonapride

Drug Info

Approved

Schizophrenia

[59], [26]

Olanzapine

Drug Info

Approved

Schizophrenia

[60], [61]

OPC-34712

Drug Info

Approved

Major depressive disorder

[62], [63]

Perazine

Drug Info

Approved

Psychotic disorder

[3]

Pergolide

Drug Info

Approved

Parkinson disease

[64], [13]

Perphenazine

Drug Info

Approved

Schizophrenia

[65], [66]

Phenoxybenzamine

Drug Info

Approved

Malignant essential hypertension

[3]

Phentolamine

Drug Info

Approved

Dermal necrosis

[67], [68]

Phenylephrine

Drug Info

Approved

Fecal incontinence

[69]

Phenyltoloxamine

Drug Info

Approved

Allergy

[3]

Pimozide

Drug Info

Approved

Schizophrenia

[70], [71]

Piperacetazine

Drug Info

Approved

Schizophrenia

[3]

Pramipexole

Drug Info

Approved

Parkinson disease

[72], [73]

Prochlorperazine

Drug Info

Approved

Nausea

[74], [75]

Pseudoephedrine

Drug Info

Approved

Nasal congestion

[76], [77]

Quetiapine

Drug Info

Approved

Schizophrenia

[26], [78], [79]

Quinagolide

Drug Info

Approved

Hyperprolactinaemia

[5]

Risperidone

Drug Info

Approved

Schizophrenia

[80], [81]

Ropinirole

Drug Info

Approved

Parkinson disease

[82], [83]

Sulpiride

Drug Info

Approved

Schizophrenia

[84], [85]

Thiethylperazine

Drug Info

Approved

Nausea

[86], [87]

Thioridazine

Drug Info

Approved

Schizophrenia

[88], [89]

Thiothixene

Drug Info

Approved

Schizophrenia

[90], [91]

Tiapride

Drug Info

Approved

Alcohol dependence

[3]

Tolazoline

Drug Info

Approved

Pulmonary hypertension

[92], [93], [3]

Ziprasidone

Drug Info

Approved

Schizophrenia

[26], [94], [81]

Zuclopenthixol

Drug Info

Approved

Schizophrenia

[95], [96]

Clinical Trial Drug(s)

[+] 43 Clinical Trial Drugs

Bis(olanzapine) pamoate monohydrate

Drug Info

Phase 3

Psychotic disorder

[3]

Blonanserin

Drug Info

Phase 3

Schizophrenia

[97], [26]

CQA 206-291

Drug Info

Phase 3

Parkinson disease

[98]

Entacapone+levodopa+carbidopa

Drug Info

Phase 3

Restless legs syndrome

[99]

Lu AF35700

Drug Info

Phase 3

Schizophrenia

[100]

P2B-001

Drug Info

Phase 3

Parkinson disease

[101]

Pridopidine

Drug Info

Phase 3

Huntington disease

[102]

RBP-7000

Drug Info

Phase 3

Non-small-cell lung cancer

[103]

Sumanirole

Drug Info

Phase 3

Parkinson disease

[104], [105]

Zicronapine

Drug Info

Phase 3

Schizophrenia

[106]

Sarizotan

Drug Info

Phase 2/3

Rett syndrome

[101]

APD-403

Drug Info

Phase 2

Vomiting

[107]

Aplindore fumarate

Drug Info

Phase 2

Schizophrenia

[26]

BIM23A760

Drug Info

Phase 2

Acromegaly

[108], [109]

BL-1020

Drug Info

Phase 2

Schizophrenia

[26]

CGS-15873A

Drug Info

Phase 2

Psychotic disorder

[110]

CLR-3001

Drug Info

Phase 2

Major depressive disorder

[111]

JNJ-37822681

Drug Info

Phase 2

Schizophrenia

[112]

Mazapertine succinate

Drug Info

Phase 2

Psychotic disorder

[113]

Ocaperidone

Drug Info

Phase 2

Schizoaffective disorder

[114], [26], [115]

ONC201

Drug Info

Phase 2

Glioma

[116], [101]

Pardoprunox

Drug Info

Phase 2

Parkinson disease

[73]

PD-143188

Drug Info

Phase 2

Psychotic disorder

[117]

ROXINDOLE

Drug Info

Phase 2

Psychotic disorder

[118], [119]

RP5063

Drug Info

Phase 2

Schizophrenia

[120]

SDZ-MAR-327

Drug Info

Phase 2

Psychotic disorder

[26], [121]

SEP--4199

Drug Info

Phase 2

Bipolar disorder

[122]

TAK-906

Drug Info

Phase 2

Diabetic gastroparesis

[123]

TBR-760

Drug Info

Phase 2

Pituitary adenoma

[124]

XP-21279

Drug Info

Phase 2

Parkinson disease

[125]

(-)-3PPP, Maryland

Drug Info

Phase 1

Schizophrenia

[126]

1192U90

Drug Info

Phase 1

Psychotic disorder

[127]

Abaperidone

Drug Info

Phase 1

Schizophrenia

[128]

ATI-9242

Drug Info

Phase 1

Schizophrenia

[100]

Carmoxirole

Drug Info

Phase 1

Hypertension

[129]

DSP-1200

Drug Info

Phase 1

Depression

[100]

Lu-02-750

Drug Info

Phase 1

Parkinson disease

[130]

Lu-AE04621

Drug Info

Phase 1

Parkinson disease

[131]

ONC206

Drug Info

Phase 1

Brain and central nervous system tumour

[132]

SKL-10406

Drug Info

Phase 1

Major depressive disorder

[133]

SSR-181507

Drug Info

Phase 1

Schizophrenia

[26]

Umespirone

Drug Info

Phase 1

Anxiety disorder

[134]

YKP-1358

Drug Info

Phase 1

Schizoaffective disorder

[26]

Patented Agent(s)

[+] 3 Patented Agents

PMID30124346-Compound-13TABLE4

Drug Info

Patented

Attention deficit hyperactivity disorder

[135]

PMID30124346-Compound-34TABLE4

Drug Info

Patented

Attention deficit hyperactivity disorder

[135]

PMID30124346-Compound-60TABLE5

Drug Info

Patented

Parkinson disease

[136], [137], [135]

Discontinued Drug(s)

[+] 43 Discontinued Drugs

Fencamfamine

Drug Info

Withdrawn from market

Depressive fatigue

[138]

Flupenthixol

Drug Info

Withdrawn from market

Schizophrenia

[139], [140]

Nomifensine

Drug Info

Withdrawn from market

Breast cancer

[141], [3]

Remoxipride

Drug Info

Withdrawn from market

Schizophrenia

[142]

Sertindole

Drug Info

Withdrawn from market

Schizophrenia

[143], [144]

(S)-amisulpride

Drug Info

Discontinued in Phase 4

Schizophrenia

[26]

Bifeprunox

Drug Info

Discontinued in Phase 3

Schizophrenia

[26]

Lamectacin

Drug Info

Discontinued in Phase 3

Bacterial infection

[145]

NOLOMIROLE HYDROCHLORIDE

Drug Info

Discontinued in Phase 3

Heart failure

[146]

Sibenadet

Drug Info

Discontinued in Phase 3

Chronic obstructive pulmonary disease

[147]

BAM-1110

Drug Info

Discontinued in Phase 2

Parkinson disease

[148]

Declopramide

Drug Info

Discontinued in Phase 2

Inflammatory bowel disease

[149]

FOSOPAMINE

Drug Info

Discontinued in Phase 2

Hypertension

[150]

Naxagolide

Drug Info

Discontinued in Phase 2

Parkinson disease

[151]

PF-217830

Drug Info

Discontinued in Phase 2

Schizophrenia

[152]

Romergoline

Drug Info

Discontinued in Phase 2

Anxiety disorder

[153]

SAVOXEPIN MESYLATE

Drug Info

Discontinued in Phase 2

Psychotic disorder

[154]

SLV-310

Drug Info

Discontinued in Phase 2

Schizophrenia

[26]

AM-831

Drug Info

Discontinued in Phase 1

Schizophrenia

[155]

DU-29894

Drug Info

Discontinued in Phase 1

Psychotic disorder

[156]

Ordopidine

Drug Info

Discontinued in Phase 1

Psychotic disorder

[157]

S-18327

Drug Info

Discontinued in Phase 1

Psychotic disorder

[158]

SDZ-GLC-756

Drug Info

Discontinued in Phase 1

Glaucoma/ocular hypertension

[159]

SLV-313

Drug Info

Discontinued in Phase 1

Schizophrenia

[26]

A-68930

Drug Info

Terminated

Hypertension

[163], [164]

AMR-103

Drug Info

Terminated

Parkinson disease

[165]

BIMG80

Drug Info

Terminated

Psychotic disorder

[166]

CGP-25454A

Drug Info

Terminated

Major depressive disorder

[167]

CP-903397

Drug Info

Terminated

Schizophrenia

[168]

Dianicline+rimonabant

Drug Info

Terminated

Tobacco dependence

[169]

E-2040

Drug Info

Terminated

Schizophrenia

[170]

Etrabamine

Drug Info

Terminated

Parkinson disease

[171]

GMC-283

Drug Info

Terminated

Schizophrenia

[26]

LY-243062

Drug Info

Terminated

Inflammation

[172]

NGD-93-1

Drug Info

Terminated

Psychotic disorder

[173]

NNC-22-0031

Drug Info

Terminated

Psychotic disorder

[174]

Org-10490

Drug Info

Terminated

Psychotic disorder

[175]

PNU-96391A

Drug Info

Terminated

Substance use disorder

[176]

RWJ-25730

Drug Info

Terminated

Psychotic disorder

[177]

SLV-307

Drug Info

Terminated

Parkinson disease

[178]

Y-20024

Drug Info

Terminated

Psychotic disorder

[179]

Y-931

Drug Info

Terminated

Schizophrenia

[26]

ZD-3638

Drug Info

Terminated

Schizophrenia

[26]

Preclinical Drug(s)

[+] 6 Preclinical Drugs

F-15063

Drug Info

Preclinical

Schizophrenia

[160]

Org-23366

Drug Info

Preclinical

Schizophrenia

[26]

PD-157695

Drug Info

Preclinical

Schizophrenia

[26]

PD-158771

Drug Info

Preclinical

Schizophrenia

[26]

PGX-200097

Drug Info

Preclinical

Schizophrenia

[161]

S32504

Drug Info

Preclinical

Parkinson disease

[162]

Mode of Action

[+] 8 Modes of Action

Antagonist

[+] 59 Antagonist drugs

Acetophenazine

Drug Info

[180], [181]

Amisulpride

Drug Info

[180], [182], [183]

Bevantolol

Drug Info

[187], [188]

Carphenazine

Drug Info

[180], [193]

Chlorpromazine

Drug Info

[194], [195], [196]

Chlorprothixene

Drug Info

[197]

Dapiprazole

Drug Info

[198]

Domperidone

Drug Info

[200], [201]

Fluspirilene

Drug Info

[206]

Haloperidol

Drug Info

[207], [180]

Iloperidone

Drug Info

[37], [26]

Loxapine

Drug Info

[213]

lumateperone tosylate

Drug Info

[41]

Meglitinides

Drug Info

[214], [215]

Metoclopramide

Drug Info

[220], [201]

Perphenazine

Drug Info

[227], [228]

Phenoxybenzamine

Drug Info

[229]

Phentolamine

Drug Info

[230]

Pimozide

Drug Info

[234], [180]

Prochlorperazine

Drug Info

[235], [236]

Risperidone

Drug Info

[241], [242]

Sulpiride

Drug Info

[215], [243], [244]

Thiethylperazine

Drug Info

[245], [246]

Thioridazine

Drug Info

[247], [248]

Thiothixene

Drug Info

[249]

Tiapride

Drug Info

[243]

Tolazoline

Drug Info

[250]

Zuclopenthixol

Drug Info

[252], [180]

Blonanserin

Drug Info

[26]

APD-403

Drug Info

[262]

BL-1020

Drug Info

[26]

ONC201

Drug Info

[116]

RP5063

Drug Info

[269], [270]

SEP--4199

Drug Info

[122]

1192U90

Drug Info

[26]

DSP-1200

Drug Info

[100]

ONC206

Drug Info

[280]

Umespirone

Drug Info

[283]

L-piperazino-3-phenyl-indane derivative 1

Drug Info

[286]

Flupenthixol

Drug Info

[288], [180]

Nomifensine

Drug Info

[289], [290]

Remoxipride

Drug Info

[180], [213]

Sertindole

Drug Info

[291], [292]

(S)-amisulpride

Drug Info

[26]

Lamectacin

Drug Info

[294], [79]

Org-23366

Drug Info

[26]

PD-157695

Drug Info

[26]

PD-158771

Drug Info

[26]

Dianicline+rimonabant

Drug Info

[320]

GMC-283

Drug Info

[26]

SLV-307

Drug Info

[327]

(+)-S-14297

Drug Info

[331]

Anti-D

Drug Info

[368]

CLR-151

Drug Info

[262]

ML321

Drug Info

[388]

nafadotride

Drug Info

[393]

S-(-)-sulpiride

Drug Info

[215], [243], [244]

[3H]N-methylspiperone

Drug Info

[414], [415]

[3H]spiperone

Drug Info

[416], [330]

Inhibitor

[+] 202 Inhibitor drugs

Aniracetam

Drug Info

[184]

Phenyltoloxamine

Drug Info

[233]

P2B-001

Drug Info

[256]

ROXINDOLE

Drug Info

[268]

TAK-906

Drug Info

[272]

TIOSPIRONE

Drug Info

[297]

MAZAPERTINE

Drug Info

[301]

PGX-200097

Drug Info

[313]

A-68930

Drug Info

[314]

A-80426

Drug Info

[315]

PD-128483

Drug Info

[325]

(+)-(1R,1'S)-berbamunine hydrochloride

Drug Info

[329]

(+)-(1R,1'S)-thaligrisine hydrochloride

Drug Info

[329]

(+)-BUTACLAMOL

Drug Info

[330]

(+/-)-nantenine

Drug Info

[332]

(-)-(1S,1'R)-O,O-dimethylgrisbine hydrochloride

Drug Info

[329]

(-)-3-(1-Propyl-piperidin-3-yl)-benzonitrile

Drug Info

[333]

(4-Ethynyl-cyclohex-3-enyl)-dipropyl-amine

Drug Info

[334]

(4-Quinolin-2-ylpiperazin-1-yl)acetic Acid

Drug Info

[335]

(5-Methoxy-chroman-3-yl)-dipropyl-amine

Drug Info

[336]

(R)-(+)-coclaurine

Drug Info

[337]

(R)-(-)-10-methyl-11-hydroxyaporphine

Drug Info

[338]

(R)-(-)-11-hydroxy-N-n-propylnoraporphine

Drug Info

[339]

(R)-(-)-2-methoxy-11-hydroxyaporphine

Drug Info

[339]

(R)-(-)-2-methoxy-N-npropylnorapomorphine

Drug Info

[339]

(R)-(-)-2-Methyl-apomorphine hydrochloride

Drug Info

[340]

(R)-(-)-2-Phenyl-apomorphine hydrochloride

Drug Info

[340]

(R)-(-)-N-ethyl-2-methoxy-11-hydroxynoraporphine

Drug Info

[339]

(R)-(-)-N-propyl-2-methoxy-11-hydroxynoraporphine

Drug Info

[339]

(S)-BULBOCAPNINE

Drug Info

[341]

(S)-secoantioquine hydrochloride

Drug Info

[329]

(S)APOMORPHINE

Drug Info

[342]

(S,R)-antioquine hydrochloride

Drug Info

[329]

(S,R)-isotetrandrine hydrochloride

Drug Info

[329]

(S,R)-pseudoxandrine hydrochloride

Drug Info

[329]

(S,S)-oxandrine hydrochloride

Drug Info

[329]

1,2,3,7,12,12a-hexahydro-1-aza-pleiadene-5,6-diol

Drug Info

[341]

1,2-Bis-[R-(-)-apomorphine-2'-oxy]ethane

Drug Info

[343]

1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane

Drug Info

[344]

1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane

Drug Info

[344]

1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane

Drug Info

[344]

1,6-bis(4-m-tolylpiperazin-1-yl)hexane

Drug Info

[344]

1,6-bis(4-phenylpiperazin-1-yl)hexane

Drug Info

[344]

1-(3-Hydroxyphenyl)-4-propylpiperazine

Drug Info

[258]

1-(4-(1H-pyrazol-1-yl)benzyl)-4-phenylpiperazine

Drug Info

[345]

1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one

Drug Info

[346]

1-(benzyloxy)-2-(2-phenylethyl)benzene

Drug Info

[347]

1-(benzyloxy)-2-[2-(3-methoxyphenyl)ethyl]benzene

Drug Info

[347]

1-Aminomethyl-3-cyclohexyl-isochroman-5,6-diol

Drug Info

[348]

1-Aminomethyl-isochroman-5,6-diol

Drug Info

[314]

1-Benzyl-4-(2-ethynyl-pyrrol-1-yl)-piperidine

Drug Info

[349]

1-Benzyl-4-(2-iodo-pyrrol-1-yl)-piperidine

Drug Info

[349]

1-Benzyl-4-(2-oxazol-5-yl-pyrrol-1-yl)-piperidine

Drug Info

[349]

1-Benzyl-4-(3-hydroxyphenyl)piperidine

Drug Info

[258]

1-Benzyl-4-(3-oxazol-5-yl-pyrrol-1-yl)-piperidine

Drug Info

[349]

1-Benzyl-4-pyrrol-1-yl-piperidine

Drug Info

[349]

1-Benzyl-4-[3-(methylsulfonyl)phenyl]piperazine

Drug Info

[258]

1-Benzyl-4-[3-(methylsulfonyl)phenyl]piperidine

Drug Info

[258]

1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine

Drug Info

[350]

1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol

Drug Info

[351]

1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine

Drug Info

[352]

1-Propyl-3-m-tolyl-piperidine hydrochloride

Drug Info

[353]

1-Propyl-3-o-tolyl-piperidine hydrochloride

Drug Info

[353]

1-Propyl-3-p-tolyl-piperidine hydrochloride

Drug Info

[353]

1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene

Drug Info

[347]

1-[2-(2-Benzyl-phenoxy)-ethyl]-piperidine

Drug Info

[233]

1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine

Drug Info

[233]

1-[3-(Methylsulfonyl)phenyl]-4-propylpiperazine

Drug Info

[258]

2,3-Dihydro-1H-indol-5-ol

Drug Info

[351]

2-(4-Dipropylamino-cyclohexylidene)-malononitrile

Drug Info

[334]

2-methoxyapomorphine

Drug Info

[343]

2-Methyl-8-phenyl-1,2,3,4-tetrahydro-isoquinoline

Drug Info

[354]

2-{[2-(2-phenylethyl)phenoxy]methyl}pyridine

Drug Info

[347]

2-{[R-(-)-Apomorphine-2'-oxy]ethoxy}-ethanol

Drug Info

[343]

3,8-dibromoboldine

Drug Info

[355]

3-(1-Propyl-pyrrolidin-3-yl)-phenol

Drug Info

[352]

3-(2,3-Dimethyl-phenyl)-1-propyl-piperidine

Drug Info

[356]

3-(2,3-Dimethyl-phenyl)-piperidine

Drug Info

[356]

3-(2,4-Dimethyl-phenyl)-1-propyl-piperidine

Drug Info

[356]

3-(2,5-Dimethyl-phenyl)-1-propyl-piperidine

Drug Info

[356]

3-(2,6-Dimethyl-phenyl)-1-propyl-piperidine

Drug Info

[356]

3-(2-Benzylamino-ethoxy)-phenol

Drug Info

[357]

3-(3,4-Dimethyl-phenyl)-1-propyl-piperidine

Drug Info

[356]

3-(3,4-Dimethyl-phenyl)-piperidine

Drug Info

[356]

3-(3,5-Dimethyl-phenyl)-1-propyl-piperidine

Drug Info

[356]

3-(3,5-Dimethyl-phenyl)-piperidine

Drug Info

[356]

3-(4-Benzyl-piperazin-1-yl)-phenol

Drug Info

[358]

3-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one

Drug Info

[330]

3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole

Drug Info

[359]

3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole

Drug Info

[359]

3-(4-Phenyl-piperidin-1-ylmethyl)-1H-indole

Drug Info

[359]

3-(N-propylpiperidin-4-yl)phenol

Drug Info

[258]

3-(Octahydro-indolizin-8-yl)-phenol

Drug Info

[360]

3-(Octahydro-quinolizin-1-yl)-phenol

Drug Info

[360]

3-(Octahydro-quinolizin-3-yl)-phenol

Drug Info

[360]

3-bromoboldine

Drug Info

[355]

3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol

Drug Info

[361]

3-Chloroboldine

Drug Info

[355]

3-Cyclohexyl-1-propyl-piperidine hydrochloride

Drug Info

[353]

100

3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol

Drug Info

[361]

101

3-Iodoboldine

Drug Info

[355]

102

3-Naphthalen-1-yl-1-propyl-pyrrolidine

Drug Info

[352]

103

3-Naphthalen-1-yl-pyrrolidine

Drug Info

[352]

104

3-Phenyl-1-propyl-piperidine hydrochloride

Drug Info

[353]

105

3-Phenyl-1-propyl-pyrrolidine

Drug Info

[352]

106

3-Phenyl-pyrrolidine

Drug Info

[352]

107

3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine

Drug Info

[347]

108

4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one

Drug Info

[357]

109

4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole

Drug Info

[358]

110

4-(4-Benzyl-piperazin-1-yl)-1H-indole

Drug Info

[358]

111

4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole

Drug Info

[358]

112

4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole

Drug Info

[358]

113

4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one

Drug Info

[362]

114

4-Benzyl-1-chroman-2-ylmethyl-piperidine

Drug Info

[330]

115

4-Benzyl-1-chroman-3-ylmethyl-piperidine

Drug Info

[330]

116

4-Benzyl-1-indan-2-ylmethyl-piperidine

Drug Info

[330]

117

5-OH-DPAT

Drug Info

[363]

118

7-(2-Amino-ethyl)-4-hydroxy-3H-benzothiazol-2-one

Drug Info

[364]

119

7-(2-Dipropylamino-ethyl)-3H-benzothiazol-2-one

Drug Info

[364]

120

A-690344

Drug Info

[366]

121

A-706149

Drug Info

[367]

122

ANOLOBINE

Drug Info

[341]

123

ANONAINE

Drug Info

[341]

124

Azaperone

Drug Info

[369]

125

Benzyl-[2-(1H-indazol-4-yloxy)-ethyl]-amine

Drug Info

[357]

126

Benzyl-[2-(1H-indol-4-yloxy)-ethyl]-amine

Drug Info

[357]

127

Bis-{[R-(-)-apomorphine-2-oxy]ethyl} ether

Drug Info

[343]

128

BOLDINE

Drug Info

[355]

129

BRL-25594

Drug Info

[370]

130

BRL-26175

Drug Info

[371]

131

CLEBOPRIDE

Drug Info

[370]

132

D-189

Drug Info

[372]

133

D-190

Drug Info

[372]

134

D-192

Drug Info

[372]

135

D-193

Drug Info

[372]

136

D-203

Drug Info

[372]

137

D-210

Drug Info

[372]

138

D-218

Drug Info

[372]

139

D-219

Drug Info

[372]

140

D-220

Drug Info

[372]

141

D-237

Drug Info

[373]

142

D-264

Drug Info

[374]

143

D-315

Drug Info

[375]

144

D-366

Drug Info

[363]

145

EPIDEPRIDE

Drug Info

[376]

146

Ethyl-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-amine

Drug Info

[377]

147

ETICLOPRIDE

Drug Info

[378]

148

Etoloxamine

Drug Info

[233]

149

FLUANISONE

Drug Info

[379]

150

FLUMEZAPINE

Drug Info

[380]

151

FLUTROLINE

Drug Info

[381]

152

GLAUCINE

Drug Info

[341]

153

IBZM

Drug Info

[376]

154

IODOPRIDE

Drug Info

[376]

155

IODOSULPIRIDE

Drug Info

[376]

156

ISOCLOZAPINE

Drug Info

[382]

157

ISOLOXAPINE

Drug Info

[383]

158

L-741626

Drug Info

[384]

159

MCL-515

Drug Info

[387]

160

MCL-516

Drug Info

[387]

161

N-(4-Dipropylaminobutyl)-4-biphenylcarboxamide

Drug Info

[390]

162

N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide

Drug Info

[386]

163

N-Ethyl-2-methylnorapomorphine hydrochloride

Drug Info

[391]

164

N-Ethyl-2-phenylnorapomorphine hydrochloride

Drug Info

[391]

165

N-Propyl-2-methylnorapomorphine hydrochloride

Drug Info

[391]

166

N-Propyl-2-phenylnorapomorphine hydrochloride

Drug Info

[391]

167

N-propylnorapomorphine

Drug Info

[392], [339]

168

NOR-ROEFRACTINE

Drug Info

[337]

169

OCTOCLOTHEPIN

Drug Info

[394]

170

PD-135111

Drug Info

[325]

171

PD-135146

Drug Info

[325]

172

PD-135188

Drug Info

[325]

173

PD-135222

Drug Info

[325]

174

PD-135385

Drug Info

[325]

175

PD-135478

Drug Info

[325]

176

PD-135540

Drug Info

[325]

177

PD-137789

Drug Info

[325]

178

PD-137821

Drug Info

[325]

179

PD-168077

Drug Info

[353]

180

PD-172938

Drug Info

[396]

181

PD-172939

Drug Info

[396]

182

PG-01037

Drug Info

[397]

183

Preclamol

Drug Info

[360]

184

Propyl-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-amine

Drug Info

[377]

185

PUKATEINE

Drug Info

[341]

186

QUINPIROLE

Drug Info

[356]

187

Ro-21-7767

Drug Info

[399]

188

Rolicyclidine

Drug Info

[400]

189

SB-258719

Drug Info

[401]

190

SB-271046

Drug Info

[402]

191

SCH-24518

Drug Info

[404]

192

SK&F-89626

Drug Info

[406]

193

SKF-89124A

Drug Info

[364]

194

SLV-314

Drug Info

[407]

195

SNAP-94847

Drug Info

[408]

196

STEPHOLIDINE

Drug Info

[409]

197

UH-232

Drug Info

[410]

198

UH-301

Drug Info

[411]

199

WAY-208466

Drug Info

[413]

200

[2-(1H-Benzoimidazol-4-yloxy)-ethyl]-benzyl-amine

Drug Info

[357]

201

[3H]7-OH-DPAT

Drug Info

[373]

202

[R-(-)-Apomorphine-2-yl]-(2'-hydroxy-ethyl)ether

Drug Info

[343]

Agonist

[+] 55 Agonist drugs

Apomorphine

Drug Info

[185]

Aripiprazole

Drug Info

[186]

Bromocriptine

Drug Info

[1], [189], [190]

Cabergoline

Drug Info

[191], [192]

Dihydroergotamine

Drug Info

[199]

Dihydroergotoxine

Drug Info

[22]

Dopamine

Drug Info

[202], [203]

Ephedrine

Drug Info

[30]

Ergonovine

Drug Info

[205]

Lisuride

Drug Info

[210], [211], [212]

Mephentermine

Drug Info

[216]

Mesoridazine

Drug Info

[217]

Metaraminol

Drug Info

[218]

Methamphetamine

Drug Info

[50]

Methyldopa

Drug Info

[219]

N-0923

Drug Info

[105]

Naphazoline

Drug Info

[223]

Nemonapride

Drug Info

[26]

Olanzapine

Drug Info

[61]

Phenylephrine

Drug Info

[231], [232]

Quetiapine

Drug Info

[26], [180], [239]

Quinagolide

Drug Info

[240]

Ziprasidone

Drug Info

[251]

Talipexole

Drug Info

[253]

CQA 206-291

Drug Info

[254]

Entacapone+levodopa+carbidopa

Drug Info

[255]

Sumanirole

Drug Info

[105]

Aplindore fumarate

Drug Info

[26], [263]

JNJ-37822681

Drug Info

[266]

Pardoprunox

Drug Info

[73]

TBR-760

Drug Info

[273]

XP-21279

Drug Info

[274]

(-)-3PPP, Maryland

Drug Info

[26]

Carmoxirole

Drug Info

[277]

Lu-02-750

Drug Info

[278]

Fencamfamine

Drug Info

[287]

NOLOMIROLE HYDROCHLORIDE

Drug Info

[295], [3]

SAVOXEPIN MESYLATE

Drug Info

[304], [3]

AM-831

Drug Info

[306]

AMR-103

Drug Info

[316]

Y-20024

Drug Info

[328], [3]

7-trans-OH-PIPAT

Drug Info

[365]

LP-12

Drug Info

[385]

LP-211

Drug Info

[386]

LP-44

Drug Info

[385]

MLS1547

Drug Info

[389]

PD 128907

Drug Info

[395]

PF-03800130

Drug Info

[262]

piribedil

Drug Info

[398]

Rotigitine

Drug Info

[13]

Uinagolide

Drug Info

[240]

UNC0006

Drug Info

[412]

UNC9975

Drug Info

[412]

UNC9994

Drug Info

[412]

WS-50030

Drug Info

[262]

Modulator

[+] 61 Modulator drugs

Cariprazine

Drug Info

[16]

Denopamine

Drug Info

[5]

Docarpamine

Drug Info

[5]

Dopexamine

Drug Info

[5]

Ibopamine hci

Drug Info

[5], [208]

Levodopa

Drug Info

[38]

Levomepromazine

Drug Info

[209]

Lurasidone hydrochloride

Drug Info

[43], [44]

OPC-34712

Drug Info

[224], [225]

Perazine

Drug Info

[226], [3]

Pergolide

Drug Info

[209]

Piperacetazine

Drug Info

[209]

Pramipexole

Drug Info

[209]

Ropinirole

Drug Info

[209]

Bis(olanzapine) pamoate monohydrate

Drug Info

[3]

Lu AF35700

Drug Info

[100]

Pridopidine

Drug Info

[257], [258]

RBP-7000

Drug Info

[259]

Zicronapine

Drug Info

[260]

Sarizotan

Drug Info

[261]

BIM23A760

Drug Info

[108]

CGS-15873A

Drug Info

[264], [3]

CLR-3001

Drug Info

[265]

Mazapertine succinate

Drug Info

[261]

Ocaperidone

Drug Info

[115]

PD-143188

Drug Info

[267]

SDZ-MAR-327

Drug Info

[271]

Abaperidone

Drug Info

[275]

ATI-9242

Drug Info

[276]

Lu-AE04621

Drug Info

[279]

SSR-181507

Drug Info

[282]

YKP-1358

Drug Info

[284]

Bifeprunox

Drug Info

[293]

Sibenadet

Drug Info

[296]

BAM-1110

Drug Info

[298]

Declopramide

Drug Info

[299]

FOSOPAMINE

Drug Info

[300], [3]

Naxagolide

Drug Info

[302]

PF-217830

Drug Info

[261]

Romergoline

Drug Info

[303]

SLV-310

Drug Info

[305]

DU-29894

Drug Info

[307]

Ordopidine

Drug Info

[308]

S-18327

Drug Info

[309]

SDZ-GLC-756

Drug Info

[310]

SLV-313

Drug Info

[311]

F-15063

Drug Info

[312]

S32504

Drug Info

[162]

BIMG80

Drug Info

[317]

CGP-25454A

Drug Info

[318]

CP-903397

Drug Info

[319]

E-2040

Drug Info

[321]

Etrabamine

Drug Info

[322]

LY-243062

Drug Info

[323]

NGD-93-1

Drug Info

[324]

NNC-22-0031

Drug Info

[174]

Org-10490

Drug Info

[209]

PNU-96391A

Drug Info

[176]

RWJ-25730

Drug Info

[326]

SDZ-208911

Drug Info

[405], [3]

SEL-73

Drug Info

[262]

Binder

[+] 5 Binder drugs

Droperidol

Drug Info

[204]

Molindone

Drug Info

[221], [222]

SKL-10406

Drug Info

[281]

Y-931

Drug Info

[26]

ZD-3638

Drug Info

[26]

Stimulator

[+] 1 Stimulator drugs

Pseudoephedrine

Drug Info

[237], [238]

Ligand

[+] 11 Ligand drugs

Aryl piperazine derivative 1

Drug Info

[135]

Aryl piperazine derivative 6

Drug Info

[135]

Benzo[d]oxazol-2(3H)-one derivative 1

Drug Info

[285]

Benzo[d]oxazol-2(3H)-one derivative 2

Drug Info

[285]

Benzo[d]oxazol-2(3H)-one derivative 3

Drug Info

[285]

PMID29334795-Compound-62

Drug Info

[285]

PMID29334795-Compound-66

Drug Info

[285]

PMID29334795-Compound-67

Drug Info

[285]

PMID30124346-Compound-13TABLE4

Drug Info

[135]

PMID30124346-Compound-34TABLE4

Drug Info

[135]

PMID30124346-Compound-60TABLE5

Drug Info

[135]

Modulator (allosteric modulator)

[+] 1 Modulator (allosteric modulator) drugs

SB269652

Drug Info

[403]

Cell-based Target Expression Variations

Top

Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Drug Binding Sites of Target

Top

Ligand Name: Bromocriptine

Ligand Info

Structure Description

Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane

PDB:6VMS

Method

Electron microscopy

Resolution

3.80 Å

Mutation

[417]

PDB Sequence

PHYNYYATLL

⁴¹

TLLIAVIVFG

⁵¹

NVLVCMAVSR

⁶¹

EKALQTTTNY

⁷¹

LIVSLAVADL

⁸¹

LVATLVMPWV

⁹¹

VYLEVVGEWK

¹⁰¹

FSRIHCDIFV

¹¹¹

TLDVMMCTAS

¹²¹

ILNLCAISID

¹³¹

RYTAVAMPML

¹⁴¹

YNTRYSSKRR

¹⁵¹

VTVMISIVWV

¹⁶¹

LSFTISCPLL

¹⁷¹

FGLNNADQNE

¹⁸¹

CIIANPAFVV

¹⁹¹

YSSIVSFYVP

²⁰¹

FIVILLVYIK

²¹¹

IYIVLRRRRK

²²¹

LVNTNRKLSQ

³⁶⁵

QKEKKATQLL

³⁷⁵

AIYLGLFIIC

³⁸⁵

WLPFFITHIL

³⁹⁵

NIHCDCNIPP

⁴⁰⁵

VLYSAFTWLG

⁴¹⁵

YVNSAINPII

⁴²⁵

YTTFNIEFRK

⁴³⁵

AFLKILHC

Residue

Distance (Å)

LEU94

4.374

PHE110

3.541

VAL111

3.516

ASP114

2.759

VAL115

3.914

CYS118

3.425

THR119

3.464

ILE122

3.417

CYS182

3.298

ILE183

3.790

ILE184

3.505

PHE189

4.963

VAL190

3.623

Residue

Distance (Å)

SER193

3.901

SER194

4.758

SER197

3.563

TRP386

3.715

PHE389

3.533

PHE390

3.570

HIS393

3.662

PRO405

4.367

TYR408

3.845

SER409

4.098

THR412

3.308

TYR416

3.780

Ligand Name: Risperidone

Ligand Info

Structure Description

Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone

PDB:6CM4

Method

X-ray diffraction

Resolution

2.87 Å

Mutation

[418]

PDB Sequence

NYYATLLTLL

⁴⁴

IAVIVFGNVL

⁵⁴

VCMAVSREKA

⁶⁴

LQTTTNYLIV

⁷⁴

SLAVADLLVA

⁸⁴

TLVMPWVVYL

⁹⁴

EVVGEWKFSR

¹⁰⁴

IHCDIFVTLD

¹¹⁴

VMMCTASALN

¹²⁴

LCAISIDRYT

¹³⁴

AVAMPTRYSS

¹⁴⁸

KRRVTVMISI

¹⁵⁸

VWVLSFTISC

¹⁶⁸

PLLFGLNNAD

¹⁷⁸

QNECIIANPA

¹⁸⁸

FVVYSSIVSF

¹⁹⁸

YVPFIVTLLV

²⁰⁸

YIKIYIVLRR

²¹⁸

RRKRNIFEML

¹⁰⁰⁷

RIDEGLRLKI

¹⁰¹⁷

YKDTEGYYTI

¹⁰²⁷

GIGHLLTKSP

¹⁰³⁷

SLNAAKSELD

¹⁰⁴⁷

KAIGRNTNGV

¹⁰⁵⁷

ITKDEAEKLF

¹⁰⁶⁷

NQDVDAAVRG

¹⁰⁷⁷

ILRNAKLKPV

¹⁰⁸⁷

YDSLDAVRRA

¹⁰⁹⁷

ALINMVFQMG

¹¹⁰⁷

ETGVAGFTNS

¹¹¹⁷

LRMLQQKRWD

¹¹²⁷

EAAVNLAKSR

¹¹³⁷

WYNQTPNRAK

¹¹⁴⁷

RVITTFRTGT

¹¹⁵⁷

WDAYSQQKEK

³⁶⁹

KATQMAAIVA

³⁷⁹

GVFIICWLPF

³⁸⁹

FITHILNIHC

³⁹⁹

DCNIPPVLYS

⁴⁰⁹

AFTWLGYVNS

⁴¹⁹

AVNPIIYTTF

⁴²⁹

NIEFRKAFLK

⁴³⁹

ILH

Residue

Distance (Å)

VAL91

4.442

LEU94

4.082

TRP100

3.497

PHE110

3.744

ASP114

2.694

VAL115

3.803

CYS118

3.334

THR119

3.727

ALA122

3.306

ILE184

4.478

PHE189

4.459

SER193

3.996

Residue

Distance (Å)

SER197

3.317

PHE198

3.715

PHE382

3.440

TRP386

3.363

PHE389

3.295

PHE390

3.556

HIS393

4.830

TYR408

3.746

SER409

4.022

THR412

3.673

TYR416

3.411

Click to View More Binding Site Information of This Target with Different Ligands

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function. Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006). Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database. The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017). Human Similarity Proteins Human Pathway Affiliation Biological Network Descriptors

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.

Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).

Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.

The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).

Human Similarity Proteins

Human Pathway Affiliation

Biological Network Descriptors

Protein Name	Pfam ID	Percentage of Identity (%)	E value
Olfactory receptor 2T34 (OR2T34)	PF13853	26.667 (40/150)	1.69E-08
Olfactory receptor 2T3 (OR2T3)	PF13853	26.667 (40/150)	2.45E-08
Olfactory receptor 4K5 (OR4K5)	PF13853	27.215 (43/158)	1.19E-06
Olfactory receptor 9A1 (OR9A1P)	PF13853	29.457 (38/129)	1.57E-06
Olfactory receptor 2L2 (OR2L2)	PF13853	28.462 (37/130)	2.44E-06
Olfactory receptor 9A2 (OR9A2)	PF13853	27.083 (39/144)	6.88E-06
Olfactory receptor 4K3 (OR4K3)	PF13853	23.404 (55/235)	1.12E-05
Olfactory receptor 10A6 (OR10A6)	PF13853	22.530 (57/253)	2.83E-05
Olfactory receptor 4D10 (OR4D10)	PF13853	26.087 (30/115)	3.06E-05
Olfactory receptor 2L5 (OR2L5)	PF13853	26.357 (34/129)	6.15E-05
Olfactory receptor 1D2 (OR1D2)	PF13853	28.906 (37/128)	6.78E-05
Olfactory receptor 1D4 (OR1D4)	PF13853	25.325 (39/154)	1.09E-04
Olfactory receptor 13A1 (OR13A1)	PF13853	23.188 (32/138)	1.68E-04
Olfactory receptor 9A4 (OR9A4)	PF13853	24.306 (35/144)	1.89E-04
Olfactory receptor 14J1 (OR14J1)	PF13853	24.762 (26/105)	2.04E-04
Olfactory receptor 4D11 (OR4D11)	PF13853	26.724 (31/116)	2.30E-04
Olfactory receptor 2AG1 (OR2AG1)	PF13853	28.455 (35/123)	2.32E-04
Olfactory receptor 1D5 (OR1D5)	PF13853	25.325 (39/154)	2.64E-04
Olfactory receptor 52Z1P (OR52Z1P)	PF13853	28.906 (37/128)	3.36E-04
Olfactory receptor 10W1 (OR10W1)	PF13853	23.529 (24/102)	3.59E-04
Olfactory receptor 2M7 (OR2M7)	PF13853	21.053 (32/152)	4.91E-04
Olfactory receptor 1L1 (OR1L1)	PF13853	28.395 (46/162)	7.45E-04
Olfactory receptor 2AG2 (OR2AG2)	PF13853	29.008 (38/131)	7.93E-04
Olfactory receptor 14A16 (OR14A16)	PF13853	26.446 (32/121)	1.00E-03
Olfactory receptor 2L3 (OR2L3)	PF13853	24.031 (31/129)	1.00E-03
Olfactory receptor 5P2 (OR5P2)	PF13853	24.113 (34/141)	1.00E-03
Olfactory receptor 2F1 (OR2F1)	PF13853	22.581 (56/248)	1.00E-03
Olfactory receptor 11A1 (OR11A1)	PF13853	24.551 (41/167)	2.00E-03
Olfactory receptor 2L8 (OR2L8)	PF13853	25.424 (30/118)	2.00E-03
Olfactory receptor 2F2 (OR2F2)	PF13853	22.400 (56/250)	2.00E-03
Olfactory receptor 8D2 (OR8D2)	PF13853	26.271 (31/118)	2.00E-03
Olfactory receptor 2AT4 (OR2AT4)	PF13853	23.529 (28/119)	2.00E-03
Olfactory receptor 4F6 (OR4F6)	PF13853	24.242 (40/165)	3.00E-03
Olfactory receptor 5AS1 (OR5AS1)	PF13853	28.846 (30/104)	3.00E-03
Putative olfactory receptor 2W6 (OR2W6P)	PF13853	22.302 (31/139)	3.00E-03
Olfactory receptor 2AJ1 (OR2AJ1)	PF13853	27.473 (25/91)	4.00E-03
Olfactory receptor 10C1 (OR10C1)	PF13853	23.438 (30/128)	5.00E-03
Olfactory receptor 4D2 (OR4D2)	PF13853	23.030 (38/165)	5.00E-03
Olfactory receptor 2D3 (OR2D3)	PF13853	32.653 (32/98)	5.00E-03
Olfactory receptor 2V1 (OR2V1)	PF13853	25.806 (32/124)	5.00E-03
Olfactory receptor 2M3 (OR2M3)	PF13853	21.642 (29/134)	5.00E-03
Olfactory receptor 5M9 (OR5M9)	PF13853	22.430 (48/214)	5.00E-03
Olfactory receptor 4K13 (OR4K13)	PF13853	26.126 (29/111)	5.00E-03
Click to Show/Hide the Information of Human Similarity Proteins

KEGG Pathway	Pathway ID	Affiliated Target
Rap1 signaling pathway	hsa04015	Affiliated Target
Class: Environmental Information Processing => Signal transduction	Pathway Hierarchy
cAMP signaling pathway	hsa04024	Affiliated Target
Class: Environmental Information Processing => Signal transduction	Pathway Hierarchy
Neuroactive ligand-receptor interaction	hsa04080	Affiliated Target
Class: Environmental Information Processing => Signaling molecules and interaction	Pathway Hierarchy
Gap junction	hsa04540	Affiliated Target
Class: Cellular Processes => Cellular community - eukaryotes	Pathway Hierarchy
Dopaminergic synapse	hsa04728	Affiliated Target
Class: Organismal Systems => Nervous system	Pathway Hierarchy

Degree	10	Degree centrality	1.07E-03	Betweenness centrality	4.80E-04
Closeness centrality	2.13E-01	Radiality	1.37E+01	Clustering coefficient	4.44E-02
Neighborhood connectivity	1.42E+01	Topological coefficient	1.22E-01	Eccentricity	12
Download	Click to Download the Full PPI Network of This Target

Chemical Structure based Activity Landscape of Target

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Drug Property Profile of Target

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(1) Molecular Weight (mw) based Drug Clustering

(2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering

(3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering

(4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering

(5) Rotatable Bond Count (rotbonds) based Drug Clustering

(6) Topological Polar Surface Area (polararea) based Drug Clustering

"RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five

Co-Targets

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Co-Targets

Co-Targets Info

Target Poor or Non Binders

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Target Poor or Non Binders

Target Poor or Non Binders Info

Target Profiles in Patients

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Target Expression
Profile (TEP)

Target Expression Profile Info

Target Affiliated Biological Pathways

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KEGG Pathway

[+] 8 KEGG Pathways

Rap1 signaling pathway

cAMP signaling pathway

Neuroactive ligand-receptor interaction

Gap junction

Dopaminergic synapse

Parkinson's disease

Cocaine addiction

Alcoholism

Panther Pathway

[+] 4 Panther Pathways

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Dopamine receptor mediated signaling pathway

Nicotine pharmacodynamics pathway

Reactome

[+] 2 Reactome Pathways

Dopamine receptors

G alpha (i) signalling events

WikiPathways

[+] 7 WikiPathways

Hypothetical Network for Drug Addiction

Monoamine GPCRs

GPCRs, Class A Rhodopsin-like

Genes and (Common) Pathways Underlying Drug Addiction

GPCR ligand binding

GPCR downstream signaling

Nicotine Activity on Dopaminergic Neurons

Target-Related Models and Studies

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Target Validation

Target Validation Info

References

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