Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0C1IW
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| Former ID |
DAP000227
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| Drug Name |
Ergonovine
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| Synonyms |
Basergin; Ergobasin; Ergobasine; Ergoklinine; Ergometrin; Ergometrina; Ergometrine; Ergometrinum; Ergostetrine; Ergotocine; Ergotrate; Margonovine; Neofemergen; Secacornin; Secometrin; Ergotrate Maleate; Lysergic acid propanolamide; Ergometrina [INN-Spanish]; Ergometrine (INN); Ergometrine [INN:BAN]; Ergometrinum[INN-Latin]; D-Lysergic acid 1-hydroxymethylethylamide; D-Lysergic acid-L-propanolamide; L-Lysergic-L(beta-hydroxyisopropylamide); N-(1-(Hydroxymethyl)ethyl)-D-lysergamide; N-(alpha-(Hydroxymethyl)ethyl)-D-lysergamide; N-(2-Hydroxy-1-methylethyl)-D(+)-lysergamide; N-[(2S)-1-hydroxypropan-2-yl]-6-methyl-9,10-didehydroergoline-8beta-carboxamide; [8beta(S)]-9,10-didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide; 9,10-Didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8beta(S)-carboxamide; 9,10-Didehydro-N-(alpha-(hydroxymethyl)ethyl)-6-methylergoline-8-beta-carboxamide
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| Drug Type |
Small molecular drug
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| Indication | Postpartum haemorrhage [ICD-11: JA43; ICD-10: O72; ICD-9: 666] | Approved | [1], [2] | |
| Therapeutic Class |
Oxytocics
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| Company |
Pfizer Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H23N3O2
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| Canonical SMILES |
CC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
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| InChI |
1S/C19H23N3O2/c1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13/h3-6,8,11,13,17,20,23H,7,9-10H2,1-2H3,(H,21,24)/t11-,13+,17+/m0/s1
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| InChIKey |
WVVSZNPYNCNODU-XTQGRXLLSA-N
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| CAS Number |
CAS 60-79-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9746, 15025041, 17182857, 36887065, 46506922, 48334665, 48483985, 49965408, 50276154, 57404547, 96024601, 99313644, 103346479, 104630924, 124558742, 124882896, 134224213, 134337542, 134970548, 135650238, 136290435, 137002473, 141839365, 144205575, 160870074, 160964585, 175268027, 179230507, 226457497, 241108708, 241201451, 242083485, 252215367, 252348890
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| ChEBI ID |
CHEBI:4822
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| ADReCS Drug ID | BADD_D00795 | |||
| SuperDrug ATC ID |
G02AB03
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| SuperDrug CAS ID |
cas=000060797
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -0.493; p = 0.034). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.785; p = 0.007). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.409; p = 0.041). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.655; p = 0.03). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.636; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.634; p = 0.008). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.653; p = 0.036). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.601; p = 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -0.337; p = 0.044). | |||
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Studied Microbe: Clostridium asparagiforme DSM 15981
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Clostridium asparagiforme DSM 15981 (log2FC = -0.42; p = 0.049). | |||
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Studied Microbe: Clostridium difficile 120
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Clostridium difficile 120 (log2FC = -0.375; p = 0.042). | |||
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Studied Microbe: Coprococcus comes ATCC 27758
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -0.402; p = 0.045). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus reuteri CF48-3A
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Ergonovine maleate can be metabolized by Lactobacillus reuteri CF48-3A (log2FC = -0.505; p = 0.047). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 148). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 006035. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Agonist profile of ergometrine (ergonovine) on a population of postsynaptic alpha-adrenoceptors. J Pharm Pharmacol. 1988 Feb;40(2):137-9. | |||
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