Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M8VE
|
|||
| Former ID |
DCL000843
|
|||
| Drug Name |
Iloperidone
|
|||
| Synonyms |
Fanapt; Fanapta; Fiapta; Zomaril; HP 873; Fanapt (TN); HP-873; ILO-522; Iloperidone [USAN:INN]; Fanapta, Zomaril, Iloperidone; Iloperidone (USAN/INN); 1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone; 4'-(3-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenone
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Schizophrenia [ICD-11: 6A20] | Approved | [1], [2] | |
| Company |
Vanda Pharmaceuticals
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C24H27FN2O4
|
|||
| Canonical SMILES |
CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
|
|||
| InChI |
1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
|
|||
| InChIKey |
XMXHEBAFVSFQEX-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 133454-47-4
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
8194581, 12014542, 14905142, 17396835, 43127698, 47359860, 47359861, 47731199, 48404440, 50064358, 51401239, 57318156, 85209859, 92712438, 93301492, 99246148, 99437181, 103176655, 103856472, 103942259, 104350273, 109693466, 117566372, 118050578, 124757285, 124899318, 125164089, 125340171, 126625565, 126656709, 126666080, 129711844, 131297754, 134339308, 135029478, 135587716, 135650377, 135692163, 135697544, 136367918, 137249342, 142584651, 144116064, 144207159, 152344064, 160645064, 162011651, 162037626, 162172136, 163123672
|
|||
| ChEBI ID |
CHEBI:65173
|
|||
| ADReCS Drug ID | BADD_D01134 | |||
| SuperDrug ATC ID |
N05AX14
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [3] | |||
| Metabolic Reaction | Hydrolysis of isoxazole | |||
| Experimental Method | High-throughput screening | |||
| Description | Iloperidone can be metabolized by gut microbiota through hydrolysis of isoxazole. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 87). | |||
| REF 2 | Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. | |||
| REF 3 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 4 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.