Drug Information
Drug General Information | Top | |||
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Drug ID |
D03JOS
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Former ID |
DNC004152
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Drug Name |
3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole
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Synonyms |
3-[(4-phenylpiperazino)methyl]-1h-indole; CHEMBL59324; 4281-72-5; 3-[(4-phenylpiperazin-1-yl)methyl]-1H-indole; NSC33115; AC1Q1ILD; 3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole; AC1L5R6D; Oprea1_259378; CBDivE_012786; CTK4I6632; MolPort-002-141-505; NSC-33115; CCG-45935; ZINC53151307; BDBM50050464; AKOS030540271; MCULE-7772581256; KB-286915
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C19H21N3
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Canonical SMILES |
C1CN(CCN1CC2=CNC3=CC=CC=C32)C4=CC=CC=C4
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InChI |
1S/C19H21N3/c1-2-6-17(7-3-1)22-12-10-21(11-13-22)15-16-14-20-19-9-5-4-8-18(16)19/h1-9,14,20H,10-13,15H2
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InChIKey |
FDOZNCJWYJMHAG-UHFFFAOYSA-N
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CAS Number |
CAS 4281-72-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Dopamine D2 receptor (D2R) | Target Info | Inhibitor | [1] |
Dopamine D3 receptor (D3R) | Target Info | Inhibitor | [1] | |
Dopamine D4 receptor (D4R) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Dopaminergic synapse | ||||
Rap1 signaling pathway | ||||
cAMP signaling pathway | ||||
Gap junction | ||||
Parkinson's disease | ||||
Cocaine addiction | ||||
Alcoholism | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Dopamine receptor mediated signaling pathway | ||||
Nicotine pharmacodynamics pathway | ||||
Reactome | Dopamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Hypothetical Network for Drug Addiction | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
Genes and (Common) Pathways Underlying Drug Addiction | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Nicotine Activity on Dopaminergic Neurons | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. |
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