Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T15514 Target Info
Target Name Hepatocyte nuclear factor 4-alpha (HNF4A)
Synonyms Transcription factor HNF-4; Transcription factor 14; TCF14; TCF-14; Nuclear receptor subfamily 2 group A member 1; NR2A1; HNF4; HNF-4-alpha
Target Type Literature-reported Target
Gene Name HNF4A
Biochemical Class Nuclear hormone receptor
UniProt ID
P41235
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-34a-5p miRNA Info
miRNA Mature AC
MIMAT0000255
Sequence uggcagugucuuagcugguugu
miRNA Species Homo sapiens
Evidence Score (E-score) 4 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay [2]
3 Luciferase Reporter Assay; Western Blot [3]
4 qRT-PCR; Western Blot [4]
Representative Target(s) Regulated by This miRNA Amphiregulin (AREG) Target Info
AREG_HUMAN
Androgen receptor (AR) Target Info
ANDR_HUMAN
miRNA Mature ID hsa-miR-34c-5p miRNA Info
miRNA Mature AC
MIMAT0000686
Sequence aggcaguguaguuagcugauugc
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-34c-5p in HepG2 cells led to a significant decrease in the activity of luciferase reporter carrying 3'UTR of HNF-4A. [1]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Cyclin-dependent kinase 4 (CDK4) Target Info
CDK4_HUMAN
miRNA Mature ID hsa-miR-449a miRNA Info
miRNA Mature AC
MIMAT0001541
Sequence uggcaguguauuguuagcuggu
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-449a in HepG2 cells led to a significant decrease in the activity of luciferase reporter carrying 3'UTR of HNF-4A. [1]
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Cyclin-dependent kinase 4 (CDK4) Target Info
CDK4_HUMAN
miRNA Mature ID hsa-miR-629-5p miRNA Info
miRNA Mature AC
MIMAT0004810
Sequence uggguuuacguugggagaacu
miRNA Species Homo sapiens
Regulation Mechanism miR-629 Suppress Directly HNF4 a Expression during Hepatocellular Transformation. [5]
Evidence Score (E-score) 2 +
1 ELISA; Luciferase Reporter Assay; Western Blot [5]
2 Western Blot [6]
Representative Target(s) Regulated by This miRNA Hepatocyte nuclear factor 4-alpha (HNF4A) Target Info
HNF4A_HUMAN
miRNA Mature ID hsa-miR-143-3p miRNA Info
miRNA Mature AC
MIMAT0000435
Sequence ugagaugaagcacuguagcuc
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [1]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Connective tissue growth factor (CTGF) Target Info
CTGF_HUMAN
miRNA Mature ID hsa-miR-216a-5p miRNA Info
miRNA Mature AC
MIMAT0000273
Sequence uaaucucagcuggcaacuguga
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [1]
Representative Target(s) Regulated by This miRNA Beclin-1 (BECN1) Target Info
BECN1_HUMAN
Extracellular matrix receptor III (CD44) Target Info
CD44_HUMAN
miRNA Mature ID hsa-miR-34b-5p miRNA Info
miRNA Mature AC
MIMAT0000685
Sequence uaggcagugucauuagcugauug
miRNA Species Homo sapiens
Regulation Mechanism hsa-miR-34b reduced the pIS- HNF4A luciferase activity. [3]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
Beta-catenin (CTNNB1) Target Info
CTNB1_HUMAN
miRNA Mature ID hsa-miR-24-1-5p miRNA Info
miRNA Mature AC
MIMAT0000079
Sequence ugccuacugagcugauaucagu
miRNA Species Homo sapiens
Regulation Mechanism Transfections with miR-24 decreased HNF4A transcripts level. [4]
Evidence Score (E-score) 1 +
1 qRT-PCR; Western Blot [4]
Representative Target(s) Regulated by This miRNA Forkhead box protein M1 (FOXM1) Target Info
FOXM1_HUMAN
Hepatocyte nuclear factor 4-alpha (HNF4A) Target Info
HNF4A_HUMAN
miRNA Mature ID hsa-miR-765 miRNA Info
miRNA Mature AC
MIMAT0003945
Sequence uggaggagaaggaaggugaug
miRNA Species Homo sapiens
Regulation Mechanism hsa-miR-765 reduced the pIS- HNF4A luciferase activity. [3]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Hepatocyte nuclear factor 4-alpha (HNF4A) Target Info
HNF4A_HUMAN
NT-3 growth factor receptor (TrkC) Target Info
NTRK3_HUMAN
miRNA Mature ID hsa-miR-766-3p miRNA Info
miRNA Mature AC
MIMAT0003888
Sequence acuccagccccacagccucagc
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Hepatocyte nuclear factor 4-alpha (HNF4A) Target Info
HNF4A_HUMAN
References  Top
REF 1 The role of microRNAs in hepatocyte nuclear factor-4alpha expression and transactivation. Biochim Biophys Acta. 2013 May;1829(5):436-42.
REF 2 MicroRNAs regulate human hepatocyte nuclear factor 4alpha, modulating the expression of metabolic enzymes and cell cycle. J Biol Chem. 2010 Feb 12;285(7):4415-22.
REF 3 In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4 expression. Drug Metab Dispos. 2012 Apr;40(4):726-33.
REF 4 MiRNA-Based Regulation of Hemostatic Factors through Hepatic Nuclear Factor-4 Alpha. PLoS One. 2016 May 2;11(5):e0154751.
REF 5 An HNF4-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011 Dec 9;147(6):1233-47.
REF 6 MicroRNAs control hepatocarcinogenesis by regulating hepatocyte nuclear factor 4alpha-inflammatory signal feedback loops. Hepatology. 2014 Nov;60(5):1466-8.

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