miRNA General Information
miRNA Mature ID hsa-miR-216a-5p
miRNA Stemloop AC MI0000292
miRNA Stemloop ID hsa-mir-216a
Sequence uaaucucagcuggcaacuguga
TTD Target(s) Regulated by This miRNA Janus kinase 2 (JAK-2) Successful Target Target Info [1]
NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Target Info [2]
Extracellular matrix receptor III (CD44) Clinical trial Target Target Info [3]
Phosphatase and tensin homolog (PTEN) Literature-reported Target Target Info [4]
Hepatocyte nuclear factor 4-alpha (HNF4A) Literature-reported Target Target Info [5]
Signal transduction protein CBL (CBL) Literature-reported Target Target Info [6]
Beclin-1 (BECN1) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA Cell division control protein 42 homolog Regulated Protein [3]
Cell migration-inducing and hyaluronan-binding protein Regulated Protein [9]
References
REF 1 miR-216a may inhibit pancreatic tumor growth by targeting JAK2. FEBS Lett. 2015 Aug 4;589(17):2224-32.
REF 2 MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation. 2009 Oct 13;120(15):1524-32.
REF 3 Expression of CD44 3'-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis. Nucleic Acids Res. 2011 Apr;39(8):3026-41.
REF 4 TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol. 2009 Jul;11(7):881-9.
REF 5 The role of microRNAs in hepatocyte nuclear factor-4alpha expression and transactivation. Biochim Biophys Acta. 2013 May;1829(5):436-42.
REF 6 miR-216a rescues dexamethasone suppression of osteogenesis, promotes osteoblast differentiation and enhances bone formation, by regulating c-Cbl-mediated PI3K/AKT pathway. Cell Death Differ. 2015 Dec;22(12):1935-45.
REF 7 MiR-216a: a link between endothelial dysfunction and autophagy. Cell Death Dis. 2014 Jan 30;5:e1029.
REF 8 Expression of CD44 3'-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis. Nucleic Acids Res. 2011 Apr;39(8):3026-41.
REF 9 Down-regulation of KIAA1199/CEMIP by miR-216a suppresses tumor invasion and metastasis in colorectal cancer.Int J Cancer. 2017 May 15;140(10):2298-2309.

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