Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86462 | Target Info | |||
| Target Name | Transthyretin (TTR) | ||||
| Synonyms | TBPA; Prealbumin; PALB; ATTR | ||||
| Target Type | Successful Target | ||||
| Gene Name | TTR | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Dasatinib | Ligand Info | |||||
| Structure Description | Crystal structure of V30M-TTR in complex with dasatinib | PDB:7ERK | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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| Ligand Name: Triclabendazole | Ligand Info | |||||
| Structure Description | Crystal structure of V30M-TTR in complex with triclabendazole | PDB:7ERI | ||||
| Method | X-ray diffraction | Resolution | 1.81 Å | Mutation | Yes | [1] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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| Ligand Name: Tolcapone | Ligand Info | |||||
| Structure Description | Structure of human transthyretin in complex with Tolcapone | PDB:4D7B | ||||
| Method | X-ray diffraction | Resolution | 1.15 Å | Mutation | No | [2] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TCW or .TCW2 or .TCW3 or :3TCW;style chemicals stick;color identity;select .A:115; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Luteolin | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION | PDB:4QXV | ||||
| Method | X-ray diffraction | Resolution | 1.12 Å | Mutation | No | [3] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LU2 or .LU22 or .LU23 or :3LU2;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Clonixin | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Transthyretin in Complex with Clonixin | PDB:5L4I | ||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | No | [4] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6J3 or .6J32 or .6J33 or :36J3;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Gemfibrozil | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Transthyretin in Complex with Gemfibrozil | PDB:5BOJ | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [5] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .4TX or .4TX2 or .4TX3 or :34TX;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Alitretinoin | Ligand Info | |||||
| Structure Description | TRANSTHYRETIN COMPLEX WITH RETINOIC ACID | PDB:1TYR | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [6] |
| PDB Sequence |
GPTGTGESKC
10 PLMVKVLDAV20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT 60 EEEFVEGIYK70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL 110 LSPYSYSTTA120 VVTNPKE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9CR or .9CR2 or .9CR3 or :39CR;style chemicals stick;color identity;select .A:15 or .A:17 or .A:52 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Diethylstilbestrol | Ligand Info | |||||
| Structure Description | The orthorhombic crystal structure of transthyretin in complex with diethylstilbestrol | PDB:1TT6 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [7] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DES or .DES2 or .DES3 or :3DES;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Flufenamic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin variant A25T in complex with flufenamic acid. | PDB:3OZL | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [8] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPTINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FLF or .FLF2 or .FLF3 or :3FLF;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Milrinone | Ligand Info | |||||
| Structure Description | STRUCTURAL ASPECTS OF INOTROPIC BIPYRIDINE BINDING: CRYSTAL STRUCTURE DETERMINATION TO 1.9 ANGSTROMS OF THE HUMAN SERUM TRANSTHYRETIN-MILRINONE COMPLEX | PDB:1TLM | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [9] |
| PDB Sequence |
TGESKCPLMV
14 KVLDAVRGSP24 AINVAVHVFR34 KAADDTWEPF44 ASGKTSESGE54 LHGLTTEEQF 64 VEGIYKVEID74 TKSYWKALGI84 SPFHEHAEVV94 FTANDSGPRR104 YTIAALLSPY 114 SYSTTAVVTN124 PKE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MIL or .MIL2 or .MIL3 or :3MIL;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Indomethacin | Ligand Info | |||||
| Structure Description | Crystal structure of wild-type human transthyretin in complex with indomethacin | PDB:4IKI | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [10] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IMN or .IMN2 or .IMN3 or :3IMN;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:108 or .A:110 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Lumiracoxib | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with lumiracoxib | PDB:4IK6 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [11] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LUR or .LUR2 or .LUR3 or :3LUR;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:110 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Flurbiprofen | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH FLURBIPROFEN | PDB:1DVT | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [12] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEQFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FLP or .FLP2 or .FLP3 or :3FLP;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Diclofenac | Ligand Info | |||||
| Structure Description | Crystal structure of human wild-type transthyretin in complex with diclofenac | PDB:3CFQ | ||||
| Method | X-ray diffraction | Resolution | 2.09 Å | Mutation | No | [13] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DIF or .DIF2 or .DIF3 or :3DIF;style chemicals stick;color identity;select .A:15 or .A:16 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Levothyroxine | Ligand Info | |||||
| Structure Description | TRANSTHYRETIN THR119MET PROTEIN STABILISATION | PDB:1F86 | ||||
| Method | X-ray diffraction | Resolution | 1.10 Å | Mutation | Yes | [14] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTM 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .T44 or .T442 or .T443 or :3T44;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Diflunisal | Ligand Info | |||||
| Structure Description | Structure of Human Transthyretin Asp38Ala Mutant in Complex with Diflunisal | PDB:6E78 | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | Yes | [15] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAAADT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1FL or .1FL2 or .1FL3 or :31FL;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: FX005 | Ligand Info | |||||
| Structure Description | The Structure of V122I Mutant Transthyretin in Complex with Tafamidis | PDB:4HIS | ||||
| Method | X-ray diffraction | Resolution | 1.20 Å | Mutation | Yes | [16] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VITNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3MI or .3MI2 or .3MI3 or :33MI;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Genistein | Ligand Info | |||||
| Structure Description | Wild type human transthyretin (TTR) complexed with genistein (TTRwt:GEN) pH 7.5 | PDB:3KGU | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [17] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GEN or .GEN2 or .GEN3 or :3GEN;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Resveratrol | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH RESVERATROL | PDB:1DVS | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [12] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEQFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .STL or .STL2 or .STL3 or :3STL;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: CHF-5074 | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin mutant A25T in complex with CHF5074, a flurbiprofen analogue | PDB:6R6I | ||||
| Method | X-ray diffraction | Resolution | 1.47 Å | Mutation | Yes | [18] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPTINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .H50 or .H502 or .H503 or :3H50;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Naringenin | Ligand Info | |||||
| Structure Description | Crystal Structure of the Wild Type TTR Binding Naringenin (TTRwt:NAR) | PDB:4DEU | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [19] |
| PDB Sequence |
ACPLMVKVLD
18 AVRGSPAINV28 AVHVFRKAAD38 DTWEPFASGK48 TSESGELHGL58 TTEEEFVEGI 68 YKVEIDTKSY78 WKALGISPFH88 EHAEVVFTAN98 DSGPRRYTIA108 ALLSPYSYST 118 TAVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NAR or .NAR2 or .NAR3 or :3NAR;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: B7-2/GM-CSF | Ligand Info | |||||
| Structure Description | Wild type human transthyretin (TTR) complexed with GC-1 (TTRwt:GC-1) | PDB:3NEE | ||||
| Method | X-ray diffraction | Resolution | 1.55 Å | Mutation | No | [20] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .B72 or .B722 or .B723 or :3B72;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Mangostin | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutated transthyretin in complex with alpha-mangostin | PDB:4Y9B | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | Yes | [21] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MKS or .MKS2 or .MKS3 or :3MKS;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121 or .A:123; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Gamma-mangostin | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutated transthyretin in complex with gamma-mangostin | PDB:4Y9E | ||||
| Method | X-ray diffraction | Resolution | 1.49 Å | Mutation | Yes | [21] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MKT or .MKT2 or .MKT3 or :3MKT;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121 or .A:123; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Rosmarinic acid | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutant human transthyretin complexed with rosmarinic acid | PDB:4PWI | ||||
| Method | X-ray diffraction | Resolution | 1.49 Å | Mutation | Yes | [22] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ROA or .ROA2 or .ROA3 or :3ROA;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Bithionol | Ligand Info | |||||
| Structure Description | Crystal structure of WT-TTR in complex with bithionol | PDB:7ERH | ||||
| Method | X-ray diffraction | Resolution | 1.55 Å | Mutation | No | [1] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .B1T or .B1T2 or .B1T3 or :3B1T;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:107 or .A:108 or .A:109 or .A:110 or .A:119 or .A:120 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Caffeic acid phenethyl ester | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutant human transthyretin complexed with caffeic acid phenethyl ester | PDB:4QRF | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [22] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .QAP or .QAP2 or .QAP3 or :3QAP;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-Sulfinoalanine | Ligand Info | |||||
| Structure Description | Transthyretin in complex with a covalent small molecule kinetic stabilizer | PDB:3HJ0 | ||||
| Method | X-ray diffraction | Resolution | 1.34 Å | Mutation | No | [23] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CSD or .CSD2 or .CSD3 or :3CSD;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:55 or .A:56 or .A:57 or .A:58 or .A:59 or .A:104; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Apigenin | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with apigenin | PDB:4WO0 | ||||
| Method | X-ray diffraction | Resolution | 1.34 Å | Mutation | No | [24] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AGI or .AGI2 or .AGI3 or :3AGI;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cysteinesulfonic Acid | Ligand Info | |||||
| Structure Description | Structure of transthyretin in complex with the kinetic stabilizer 201 | PDB:5TZL | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [25] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .OCS or .OCS2 or .OCS3 or :3OCS;style chemicals stick;color identity;select .A:11 or .A:12 or .A:13 or .A:55 or .A:56 or .A:57 or .A:58 or .A:59 or .A:104; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 2-hydroxy-3,5-diiodobenzoic acid | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with 3,5-diiodosalicylic acid | PDB:3B56 | ||||
| Method | X-ray diffraction | Resolution | 1.55 Å | Mutation | No | [26] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DIU or .DIU2 or .DIU3 or :3DIU;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: PMID26394986-Compound-44 | Ligand Info | |||||
| Structure Description | Crystal Structure of V30M transthyretin complexed with (-)-epigallocatechin gallate (EGCG) | PDB:3NG5 | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [27] |
| PDB Sequence |
KCPLMVKVLD
18 AVRGSPAINV28 AMHVFRKAAD38 DTWEPFASGK48 TSESGELHGL58 TTEEEFVEGI 68 YKVEIDTKSY78 WKALGISPFH88 EHAEVVFTAN98 DSGPRRYTIA108 ALLSPYSYST 118 TAVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .KDH or .KDH2 or .KDH3 or :3KDH;style chemicals stick;color identity;select .A:18 or .A:20 or .A:21 or .A:23 or .A:31 or .A:32 or .A:33 or .A:41 or .A:43 or .A:44 or .A:45 or .A:46 or .A:72 or .A:78 or .A:79 or .A:82 or .A:84 or .A:90 or .A:113; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-1 | PDB:4ABQ | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [28] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .4V2 or .4V22 or .4V23 or :34V2;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: PMID26560530-Compound-23 | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with ferulic acid and curcumin. | PDB:4PME | ||||
| Method | X-ray diffraction | Resolution | 1.26 Å | Mutation | No | [29] |
| PDB Sequence |
KCPLMVKVLD
18 AVRGSPAINV28 AVHVFRKAAD38 DTWEPFASGK48 TSESGELHGL58 TTEEEFVEGI 68 YKVEIDTKSY78 WKALGISPFH88 EHAEVVFTAN98 DSGPRRYTIA108 ALLSPYSYST 118 TAVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CUR or .CUR2 or .CUR3 or :3CUR;style chemicals stick;color identity;select .A:15 or .A:17 or .A:24 or .A:51 or .A:52 or .A:53 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 1-anilinonaphthalene-8-sulfonic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with 1-anilino-8-naphthalene sulfonate | PDB:3CFN | ||||
| Method | X-ray diffraction | Resolution | 1.87 Å | Mutation | No | [13] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .2AN or .2AN2 or .2AN3 or :32AN;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: GC-24 | Ligand Info | |||||
| Structure Description | V30M mutant human transthyretin (TTR) complexed with GC-24 (V30M:GC-24) | PDB:3NEX | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [20] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G24 or .G242 or .G243 or :3G24;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Chrysin | Ligand Info | |||||
| Structure Description | Crystal Structure of the Wild Type TTR Binding Chrysin (TTRwt:CHR) | PDB:4DES | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [19] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .57D or .57D2 or .57D3 or :357D;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Kaempferol | Ligand Info | |||||
| Structure Description | Crystal Structure of the Wild Type TTR Binding Kaempferol (TTRwt:KAE) | PDB:4DET | ||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [19] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .KMP or .KMP2 or .KMP3 or :3KMP;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: PMID27414413-Compound-Figure6right | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with Benzbromarone | PDB:7ACU | ||||
| Method | X-ray diffraction | Resolution | 1.54 Å | Mutation | No | [30] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .R75 or .R752 or .R753 or :3R75;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-Deoxytolcapone | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with 3-deoxytolcapone, a tolcapone analogue | PDB:6SUG | ||||
| Method | X-ray diffraction | Resolution | 1.21 Å | Mutation | No | [31] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LVB or .LVB2 or .LVB3 or :3LVB;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-O-Methyltolcapone | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with 3-O-methyltolcapone, a tolcapone analogue | PDB:6SUH | ||||
| Method | X-ray diffraction | Resolution | 1.26 Å | Mutation | No | [31] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LVE or .LVE2 or .LVE3 or :3LVE;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2~{R})-2-[4-(3,5-dimethylphenyl)-3-fluoranyl-phenyl]propanoic acid | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue | PDB:6R67 | ||||
| Method | X-ray diffraction | Resolution | 1.30 Å | Mutation | No | [18] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JTE or .JTE2 or .JTE3 or :3JTE;style chemicals stick;color identity;select .A:15 or .A:16 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (3',5'-Dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue | PDB:6R66 | ||||
| Method | X-ray diffraction | Resolution | 1.30 Å | Mutation | No | [18] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JTN or .JTN2 or .JTN3 or :3JTN;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]propanoic acid | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with CHF4795, a flurbiprofen analogue | PDB:6R68 | ||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | No | [18] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JTK or .JTK2 or .JTK3 or :3JTK;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-[(2,7-Dichlorofluoren-9-ylidene)amino]oxyacetic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with (2,7-Dichloro-fluoren-9-ylideneaminooxy)-acetic acid. | PDB:5E4A | ||||
| Method | X-ray diffraction | Resolution | 1.33 Å | Mutation | No | [32] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5JW or .5JW2 or .5JW3 or :35JW;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:107 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:120 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 8-Chloranyl-9-oxidanylidene-xanthene-3-carboxylic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with 8-chloro-9-oxo-9H-xanthene-3-carboxylic acid | PDB:7EJQ | ||||
| Method | X-ray diffraction | Resolution | 1.15 Å | Mutation | No | [33] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .J5R or .J5R2 or .J5R3 or :3J5R;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 4-Chloranyl-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid | PDB:7DT3 | ||||
| Method | X-ray diffraction | Resolution | 1.20 Å | Mutation | No | [33] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTN
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HG6 or .HG62 or .HG63 or :3HG6;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 4-Chloranyl-9-oxidanylidene-xanthene-2-carboxylic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid | PDB:7DT5 | ||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [33] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HH9 or .HH92 or .HH93 or :3HH9;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:107 or .A:108 or .A:110 or .A:117 or .A:119 or .A:120 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 2-Oxidanyl-6-(Phenylcarbonyl)benzo[de]isoquinoline-1,3-Dione | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with L6 | PDB:5AYT | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [34] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .L6Y or .L6Y2 or .L6Y3 or :3L6Y;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,3,5,6,8,9,11,12,14,15-Decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecine-18-carboxylic acid | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutated transthyretin in complex with 4'-caroboxybenzo-18-Crown-6 | PDB:6IMY | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | Yes | [35] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AJU or .AJU2 or .AJU3 or :3AJU;style chemicals stick;color identity;select .A:21 or .A:26 or .A:27 or .A:48 or .A:77 or .A:78 or .A:81 or .A:82; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-[(2r,3s)-3-[(3,4-Dihydroxyphenyl)methyl]-2-Methylbutyl]benzene-1,2-Diol | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutant human transthyretin complexed with nordihydroguaiaretic acid | PDB:4PWJ | ||||
| Method | X-ray diffraction | Resolution | 1.55 Å | Mutation | Yes | [22] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .30Z or .30Z2 or .30Z3 or :330Z;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (-)-Dihydroguaiaretic acid | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutant human transthyretin complexed with dihydroguaiaretic acid | PDB:4PWK | ||||
| Method | X-ray diffraction | Resolution | 1.59 Å | Mutation | Yes | [22] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PWK or .PWK2 or .PWK3 or :3PWK;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Phenylethyl 3-methylcaffeate | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutant human transthyretin complexed with ferulic acid phenethyl ester | PDB:4PWF | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | Yes | [22] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PWF or .PWF2 or .PWF3 or :3PWF;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Glabridin | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutant human transthyretin complexed with glabridin | PDB:4N87 | ||||
| Method | X-ray diffraction | Resolution | 1.79 Å | Mutation | Yes | [36] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GBJ or .GBJ2 or .GBJ3 or :3GBJ;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Ethyl caffeate | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutant human transthyretin complexed with caffeic acid ethyl ester | PDB:4PWG | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [22] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0XR or .0XR2 or .0XR3 or :30XR;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Prenyl caffeate | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutant human transthyretin complexed with caffeic acid 1,1-dimethylallyl ester | PDB:4PWH | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [22] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PWH or .PWH2 or .PWH3 or :3PWH;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-Isomangostin | Ligand Info | |||||
| Structure Description | Crystal structure of V30M mutated transthyretin in complex with 3-isomangostin | PDB:4Y9G | ||||
| Method | X-ray diffraction | Resolution | 1.89 Å | Mutation | Yes | [21] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MKU or .MKU2 or .MKU3 or :3MKU;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Dichlorophen | Ligand Info | |||||
| Structure Description | Crystal structure of V30M-TTR in complex with dichlorophen | PDB:7ERJ | ||||
| Method | X-ray diffraction | Resolution | 1.89 Å | Mutation | Yes | [1] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 MHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JAL or .JAL2 or .JAL3 or :3JAL;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[(E)-2-(4-Borono-2-Chlorophenyl)ethenyl]benzoic Acid | Ligand Info | |||||
| Structure Description | Wild-type Transthyretin in complex with 3-[(1E)-2-(2-Chloro-4-boronic acid)ethenyl]benzoic Acid | PDB:5U4E | ||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | No | [37] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .XLB or .XLB2 or .XLB3 or :3XLB;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[(E)-2-(4-Hydroxyphenyl)ethenyl]benzoic Acid | Ligand Info | |||||
| Structure Description | Wild-type Transthyretin in complex with 3-[(1E)-2-(4-Hydroxyphenyl)ethenyl]benzoic Acid | PDB:5U4B | ||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | No | [37] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .XOS or .XOS2 or .XOS3 or :3XOS;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Transthyretin-IN-1 | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with (E)-3-(((3,5-dibromo-2-hydroxybenzylidene)amino)oxy)propanoic acid. | PDB:6TI9 | ||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | No | [38] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ND5 or .ND52 or .ND53 or :3ND5;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: [(E)-Ethene-1,2-Diylbis(3-Chloro-4,1-Phenylene)]diboronic Acid | Ligand Info | |||||
| Structure Description | Wild-type Transthyretin in complex with 1,1'-(1E)-(1,2-Ethenediyl)bis[2-chloro-4-boronic acid]benzene | PDB:5U4F | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [37] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IWW or .IWW2 or .IWW3 or :3IWW;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: {4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]phenyl}boronic Acid | Ligand Info | |||||
| Structure Description | Wild-type Transthyretin in complex with 5-[(1E)-2-(4-Boronic acid)ethenyl]-1,3-benzenediol | PDB:5U48 | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [37] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .S4B or .S4B2 or .S4B3 or :3S4B;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[(E)-2-(2-Chloro-4-Hydroxyphenyl)ethenyl]benzoic Acid | Ligand Info | |||||
| Structure Description | Wild-type Transthyretin in complex with 3-[(1E)-2-(2-Chloro-4-hydroxyphenyl)ethenyl]benzoic Acid | PDB:5U4D | ||||
| Method | X-ray diffraction | Resolution | 1.55 Å | Mutation | No | [37] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .XLO or .XLO2 or .XLO3 or :3XLO;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[(E)-2-(4-Boronophenyl)ethenyl]benzoic Acid | Ligand Info | |||||
| Structure Description | Wild-type Transthyretin in complex with 3-[(1E)-2-(4-Boronic acid)ethenyl]benzoic Acid | PDB:5U4C | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [37] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .XBS or .XBS2 or .XBS3 or :3XBS;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[(~{E})-(4-hydroxyphenyl)methylideneamino]oxypropanoic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with (E)-3-(((4-hydroxybenzylidene)amino)oxy)propanoic acid | PDB:6TJN | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [38] |
| PDB Sequence |
KCPLMVKVLD
18 AVRGSPAINV28 AVHVFRKAAD38 DTWEPFASGK48 TSESGELHGL58 TTEEEFVEGI 68 YKVEIDTKSY78 WKALGISPFH88 EHAEVVFTAN98 DSGPRRYTIA108 ALLSPYSYST 118 TAVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NEK or .NEK2 or .NEK3 or :3NEK;style chemicals stick;color identity;select .A:15 or .A:17 or .A:24 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[(E)-2-(7,7-dihydroxy-9-oxo-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-3-yl)ethenyl]-7,7-dihydroxy-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-9-one | Ligand Info | |||||
| Structure Description | Transthyretin in complex with (E)-5,5'-(ethene-1,2-diyl)bis(1,1-dihydroxy-3-oxo-1,3-dihydrobenzo[c][1,2]oxaborol-1-uide) | PDB:6U0Q | ||||
| Method | X-ray diffraction | Resolution | 1.75 Å | Mutation | No | [39] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .S2B or .S2B2 or .S2B3 or :3S2B;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: {3-Chloro-4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]phenyl}boronic Acid | Ligand Info | |||||
| Structure Description | Wild-type Transthyretin in complex with 5-[(1E)-2-(2-Chloro-4-boronic acid)ethenyl]-1,3-benzenediol | PDB:5U4A | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [37] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7VG or .7VG2 or .7VG3 or :37VG;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 5-[(E)-2-(2-Chloro-4-Hydroxyphenyl)ethenyl]benzene-1,3-Diol | Ligand Info | |||||
| Structure Description | Wild-type Transthyretin in complex with 5-[(1E)-2-(2-Chloro-4-hydroxyphenyl)ethenyl]-1,3-benzenediol | PDB:5U49 | ||||
| Method | X-ray diffraction | Resolution | 2.22 Å | Mutation | No | [37] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .S2L or .S2L2 or .S2L3 or :3S2L;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: 7-Hydroxy-3-[(E)-2-(4-Hydroxy-3,5-Dimethylphenyl)ethenyl]-4-Methyl-2h-Chromen-2-One | Ligand Info | |||||
| Structure Description | Transthyretin in complex with the fluorescent folding sensor (E)-7-hydroxy-3-(4-hydroxy-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one | PDB:4KY2 | ||||
| Method | X-ray diffraction | Resolution | 1.13 Å | Mutation | No | [40] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1W3 or .1W32 or .1W33 or :31W3;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 3-(Dimethylamino)-5-[(E)-2-(4-Hydroxy-3,5-Dimethylphenyl)ethenyl]benzoic Acid | Ligand Info | |||||
| Structure Description | Transthyretin in complex with (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoic acid | PDB:4L1T | ||||
| Method | X-ray diffraction | Resolution | 1.16 Å | Mutation | No | [41] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1WZ or .1WZ2 or .1WZ3 or :31WZ;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[3-(3,5-Dimethyl-1h-Pyrazol-4-Yl)propoxy]-4-Fluorobenzoic Acid | Ligand Info | |||||
| Structure Description | The Structure of V122I Mutant Transthyretin in Complex with AG10 | PDB:4HIQ | ||||
| Method | X-ray diffraction | Resolution | 1.18 Å | Mutation | Yes | [16] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVITNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .16V or .16V2 or .16V3 or :316V;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-[(3,5-Dichloro-4-Hydroxyphenyl)amino]benzoic Acid | Ligand Info | |||||
| Structure Description | Human Transthyretin (TTR) complexed with 2-((3,5-dichloro-4-hydroxyphenyl)amino)benzoic acid | PDB:3M1O | ||||
| Method | X-ray diffraction | Resolution | 1.20 Å | Mutation | No | [42] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .CJZ or .CJZ2 or .CJZ3 or :3CJZ;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Perfluorooctanoic acid | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Transthyretin in Complex with Perfluorooctanoic acid (PFOA) | PDB:5JID | ||||
| Method | X-ray diffraction | Resolution | 1.20 Å | Mutation | No | [4] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8PF or .8PF2 or .8PF3 or :38PF;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3,3',5,5'-Tetrachloro-4,4'-biphenyldiol | Ligand Info | |||||
| Structure Description | High Resolution Structure of Wild Type Human Transthyretin in Complex with 3,3',5,5'-tetrachloro-[1,1'-biphenyl]-4,4'diol | PDB:4MAS | ||||
| Method | X-ray diffraction | Resolution | 1.22 Å | Mutation | No | [43] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNPK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PCQ or .PCQ2 or .PCQ3 or :3PCQ;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 4-Bromo-3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride | Ligand Info | |||||
| Structure Description | Kinetic Stabilization of transthyretin through covalent modification of K15 by 4-bromo-3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide | PDB:4FI8 | ||||
| Method | X-ray diffraction | Resolution | 1.22 Å | Mutation | No | [44] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0UC or .0UC2 or .0UC3 or :30UC;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 16alpha-Bromo-17beta-estradiol | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with 16-alpha-bromo-estradiol | PDB:4PM1 | ||||
| Method | X-ray diffraction | Resolution | 1.23 Å | Mutation | No | [29] |
| PDB Sequence |
KCPLMVKVLD
18 AVRGSPAINV28 AVHVFRKAAD38 DTWEPFASGK48 TSESGELHGL58 TTEEEFVEGI 68 YKVEIDTKSY78 WKALGISPFH88 EHAEVVFTAN98 DSGPRRYTIA108 ALLSPYSYST 118 TAVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ESZ or .ESZ2 or .ESZ3 or :3ESZ;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode | PDB:4TQI | ||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [45] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6BD or .6BD2 or .6BD3 or :36BD;style chemicals stick;color identity;select .A:15 or .A:17 or .A:52 or .A:54 or .A:106 or .A:108 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone | Ligand Info | |||||
| Structure Description | Transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone | PDB:3P3R | ||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [46] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3M1 or .3M12 or .3M13 or :33M1;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,6-Dichloro-4-[5-(3-Hydroxyphenyl)-1,3,4-Oxadiazol-2-Yl]phenol | Ligand Info | |||||
| Structure Description | High resolution crystal structure of human transthyretin bound to ligand and conjugates of 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate | PDB:4YDM | ||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [47] |
| PDB Sequence |
CPLMVVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .4AJ or .4AJ2 or .4AJ3 or :34AJ;style chemicals stick;color identity;select .A:13 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-[3,4-Bis(Oxidanyl)phenyl]-7-Chloranyl-5-Oxidanyl-Chromen-4-One | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with luteolin-Cl at 1.25 A resolution | PDB:5EN3 | ||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [48] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7LU or .7LU2 or .7LU3 or :37LU;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N~6~-sulfo-L-lysine | Ligand Info | |||||
| Structure Description | High resolution crystal structure of human transthyretin bound to ligand and conjugates of 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate | PDB:4YDM | ||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [47] |
| PDB Sequence |
CPLMVVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .4AK or .4AK2 or .4AK3 or :34AK;style chemicals stick;color identity;select .A:13 or .A:14 or .A:16 or .A:17 or .A:24 or .A:52 or .A:53 or .A:54 or .A:106 or .A:107 or .A:108 or .A:109; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: trans-Resveratrol 3-O-|A-D-Glucuronide | Ligand Info | |||||
| Structure Description | Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-3-O- glucuronide | PDB:5AKS | ||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | No | [49] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .R3X or .R3X2 or .R3X3 or :3R3X;style chemicals stick;color identity;select .A:15 or .A:17 or .A:24 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Perfluorooctanesulfonic acid | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Transthyretin in Complex with Perfluoroktansulfonsyra (PFOS) | PDB:5JIM | ||||
| Method | X-ray diffraction | Resolution | 1.26 Å | Mutation | No | [4] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .P8S or .P8S2 or .P8S3 or :3P8S;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-(1,3-Benzoxazol-2-Yl)-2,6-Dimethylphenol | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with 2-(3,5-Dimethyl-4-hydroxyphenyl)benzoxazole | PDB:2QGC | ||||
| Method | X-ray diffraction | Resolution | 1.30 Å | Mutation | No | [50] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MR4 or .MR42 or .MR43 or :3MR4;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,5-dichloro-N-(3,5-dibromo-4-hydroxyphenyl)benzamide | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,5-dichlorobenzamide | PDB:3ESO | ||||
| Method | X-ray diffraction | Resolution | 1.31 Å | Mutation | No | [51] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DZ2 or .DZ22 or .DZ23 or :3DZ2;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,6-dibromo-4-[(E)-2-(2,6-dimethoxyphenyl)ethenyl]aniline | Ligand Info | |||||
| Structure Description | Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dimethoxystyryl)aniline | PDB:3IMW | ||||
| Method | X-ray diffraction | Resolution | 1.31 Å | Mutation | No | [52] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IW6 or .IW62 or .IW63 or :3IW6;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-3,5-dimethylbenzamide | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-3,5-dimethyl-4-hydroxybenzamide | PDB:3ESP | ||||
| Method | X-ray diffraction | Resolution | 1.31 Å | Mutation | No | [51] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DZ3 or .DZ32 or .DZ33 or :3DZ3;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-Fluorophenyl 3-[(E)-2-(4-Hydroxy-3,5-Dimethylphenyl)ethenyl]benzoate | Ligand Info | |||||
| Structure Description | Transthyretin in complex with a covalent small molecule kinetic stabilizer | PDB:3HJ0 | ||||
| Method | X-ray diffraction | Resolution | 1.34 Å | Mutation | No | [23] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .A93 or .A932 or .A933 or :3A93;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| Ligand Name: 2,6-Dichloro-4-[5-(4-Hydroxyphenyl)-1,3,4-Oxadiazol-2-Yl]phenol | Ligand Info | |||||
| Structure Description | High resolution crystal structure of human transthyretin bound to ligand and conjugates of 4-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate | PDB:4YDN | ||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [47] |
| PDB Sequence |
CPLMVVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .4B8 or .4B82 or .4B83 or :34B8;style chemicals stick;color identity;select .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 4-[5-(3,5-Dichloro-4-Hydroxyphenyl)-1,3,4-Oxadiazol-2-Yl]phenyl Sulfurofluoridate | Ligand Info | |||||
| Structure Description | High resolution crystal structure of human transthyretin bound to ligand and conjugates of 4-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)phenyl fluorosulfate | PDB:4YDN | ||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [47] |
| PDB Sequence |
CPLMVVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .2WN or .2WN2 or .2WN3 or :32WN;style chemicals stick;color identity;select .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 7-O-Methylluteolin | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with luteolin-MeO at 1.35 A resolution | PDB:5IHH | ||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [48] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6B5 or .6B52 or .6B53 or :36B5;style chemicals stick;color identity;select .A:15 or .A:17 or .A:24 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: N-(3,5-Dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide | PDB:3ESN | ||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [51] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DZ1 or .DZ12 or .DZ13 or :3DZ1;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-{3-[(E)-2-(4-Hydroxy-3,5-Dimethylphenyl)ethenyl]phenyl}prop-2-Enamide | Ligand Info | |||||
| Structure Description | Transthyretin in complex with (E)-N-(3-(4-hydroxy-3,5-dimethylstyryl)phenyl)acrylamide | PDB:4HJU | ||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [53] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .16L or .16L2 or .16L3 or :316L;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: trans-Resveratrol 4'-O-glucuronide | Ligand Info | |||||
| Structure Description | Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-4'-O- glucuronide | PDB:5AKT | ||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [49] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .R4G or .R4G2 or .R4G3 or :3R4G;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Resveratrol-3-O-sulfate | Ligand Info | |||||
| Structure Description | Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-3-O-sulfate | PDB:5AL0 | ||||
| Method | X-ray diffraction | Resolution | 1.39 Å | Mutation | No | [49] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .R3S or .R3S2 or .R3S3 or :3R3S;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,4,5-Trichlorophenoxyacetic acid | Ligand Info | |||||
| Structure Description | Crystal Structure Of Human Transthyretin in complex with 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) | PDB:6GR7 | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [54] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .F52 or .F522 or .F523 or :3F52;style chemicals stick;color identity;select .A:15 or .A:16 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,6-Dibromo-4-[2-(2,6-dichlorophenyl)ethyl]phenol | Ligand Info | |||||
| Structure Description | Transthyretin in complex with 2,6-dibromo-4-(2,6-dichlorophenethyl)phenol | PDB:3IMS | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [52] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IW2 or .IW22 or .IW23 or :3IW2;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[5-(3,5-Dichloro-4-Hydroxyphenyl)-1,3,4-Oxadiazol-2-Yl]benzenesulfonyl Fluoride | Ligand Info | |||||
| Structure Description | Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide | PDB:4FI7 | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [44] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0UA or .0UA2 or .0UA3 or :30UA;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-(7-Chloro-1,3-Benzoxazol-2-Yl)-2,6-Diiodophenol | Ligand Info | |||||
| Structure Description | Structure of transthyretin in complex with the kinetic stabilizer 201 | PDB:5TZL | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [25] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IIH or .IIH2 or .IIH3 or :3IIH;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-[(E)-2-(3-aminophenyl)ethenyl]-2,6-dibromoaniline | Ligand Info | |||||
| Structure Description | Transthyretin in complex with (E)-4-(3-aminostyryl)-2,6-dibromoaniline | PDB:3IMU | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [52] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IW4 or .IW42 or .IW43 or :3IW4;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-[(E)-2-(4-aminophenyl)ethenyl]-2,6-dibromophenol | Ligand Info | |||||
| Structure Description | Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromophenol | PDB:3IMT | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [52] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IW3 or .IW32 or .IW33 or :3IW3;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-(3,5-dibromo-4-hydroxyphenyl)benzamide | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) in complex with N-(3,5-Dibromo-4-hydroxyphenyl)benzamide | PDB:3CN4 | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [55] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LJ5 or .LJ52 or .LJ53 or :3LJ5;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Tetrabromobisphenol A | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Transthyretin in Complex with Tetrabromobisphenol A (TBBPA) | PDB:5HJG | ||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | No | [56] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .XDI or .XDI2 or .XDI3 or :3XDI;style chemicals stick;color identity;select .A:13 or .A:15 or .A:16 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: {[(2,7-Dibromo-9h-Fluoren-9-Ylidene)amino]oxy}acetic Acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with (2,7-Dibromo-fluoren-9-ylideneaminooxy)-acetic acid | PDB:5E23 | ||||
| Method | X-ray diffraction | Resolution | 1.41 Å | Mutation | No | [32] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .L32 or .L322 or .L323 or :3L32;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:107 or .A:108 or .A:110 or .A:119 or .A:120 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,2',4,4'-Tetrahydroxybenzophenone | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Transthyretin in Complex with 2,2',4,4'-tetrahydroxybenzophenone (BP2) | PDB:5JIQ | ||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | No | [4] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .27M or .27M2 or .27M3 or :327M;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-(3,5-Dimethylphenyl)-1,3-Benzoxazole | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with 2-(3,5-Dimethylphenyl)benzoxazole | PDB:2QGE | ||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | No | [50] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MR6 or .MR62 or .MR63 or :3MR6;style chemicals stick;color identity;select .A:15 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-[3-(2-fluorophenoxy)propyl]-3,5-dimethyl-1H-pyrazole | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with 4-(3-(2-flourophenoxy)propyl)-3,5-dimethyl-1H-pyrazole | PDB:3P3T | ||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | No | [46] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3M3 or .3M32 or .3M33 or :33M3;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-[4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl]propanamide | Ligand Info | |||||
| Structure Description | Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide | PDB:4HJT | ||||
| Method | X-ray diffraction | Resolution | 1.45 Å | Mutation | No | [53] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .18A or .18A2 or .18A3 or :318A;style chemicals stick;color identity;select .A:15 or .A:17 or .A:52 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[5-(3,5-Dichlorophenyl)-1,3,4-Oxadiazol-2-Yl]benzenesulfonyl Fluoride | Ligand Info | |||||
| Structure Description | Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide | PDB:4FI6 | ||||
| Method | X-ray diffraction | Resolution | 1.46 Å | Mutation | No | [44] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .0U7 or .0U72 or .0U73 or :30U7;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4'-(4-{4-[(2-Carboxyphenyl)amino]phenoxy}butoxy)-1,1'-biphenyl-4-carboxylic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (4 carbon linker) | PDB:2FBR | ||||
| Method | X-ray diffraction | Resolution | 1.46 Å | Mutation | No | [57] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .44C or .44C2 or .44C3 or :344C;style chemicals stick;color identity;select .A:15 or .A:16 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-[(E)-2-(4-aminophenyl)ethenyl]-2,6-dibromoaniline | Ligand Info | |||||
| Structure Description | Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromoaniline | PDB:3IMV | ||||
| Method | X-ray diffraction | Resolution | 1.47 Å | Mutation | No | [52] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IW5 or .IW52 or .IW53 or :3IW5;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: 2,6-Dinitro-p-cresol | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Transthyretin in Complex with 2,6-Dinitro-p-cresol (DNPC) | PDB:5L4F | ||||
| Method | X-ray diffraction | Resolution | 1.48 Å | Mutation | No | [4] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6J1 or .6J12 or .6J13 or :36J1;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| Ligand Name: 4-(1,3-Benzoxazol-2-Yl)-2,6-Dibromophenol | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with 2-(3,5-Dibromo-4-hydroxyphenyl)benzoxazole | PDB:2QGD | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [50] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MR5 or .MR52 or .MR53 or :3MR5;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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||||||
| Ligand Name: 4-[5-(2-Ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole | PDB:3P3U | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [46] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
|
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3M4 or .3M42 or .3M43 or :33M4;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Ligand Name: Daidzein-7-o-glucuronide | Ligand Info | |||||
| Structure Description | Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: daidzein-7-O- glucuronide | PDB:5AL8 | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [49] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .D75 or .D752 or .D753 or :3D75;style chemicals stick;color identity;select .A:13 or .A:15 or .A:16 or .A:17 or .A:54 or .A:56 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: S-(4-Fluorophenyl) 3-(Dimethylamino)-5-[(E)-2-(4-Hydroxy-3,5-Dimethylphenyl)ethenyl]benzenecarbothioate | Ligand Info | |||||
| Structure Description | Covalent modification of transthyretin K15 by yielding the fluorescent conjugate (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzamide | PDB:4L1S | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [41] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1W4 or .1W42 or .1W43 or :31W4;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: [(9h-Fluoren-9-Ylideneamino)oxy]acetic Acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)ethanoic acid | PDB:4TQH | ||||
| Method | X-ray diffraction | Resolution | 1.51 Å | Mutation | No | [45] |
| PDB Sequence |
KCPLMVKVLD
18 AVRGSPAINV28 AVHVFRKAAD38 DTWEPFASGK48 TSESGELHGL58 TTEEEFVEGI 68 YKVEIDTKSY78 WKALGISPFH88 EHAEVVFTAN98 DSGPRRYTIA108 ALLSPYSYST 118 TAVVTNP
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ES8 or .ES82 or .ES83 or :3ES8;style chemicals stick;color identity;select .A:15 or .A:16 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,6-dibromo-4-[(E)-2-phenylethenyl]phenol | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxystilbene | PDB:3CN1 | ||||
| Method | X-ray diffraction | Resolution | 1.52 Å | Mutation | No | [55] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LJ2 or .LJ22 or .LJ23 or :3LJ2;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) in complex with 3,5-Dimethyl-4-hydroxystilbene | PDB:3CN0 | ||||
| Method | X-ray diffraction | Resolution | 1.52 Å | Mutation | No | [55] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LJ1 or .LJ12 or .LJ13 or :3LJ1;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3,5-Dibromobiphenyl-4-ol | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxybiphenyl | PDB:3CN2 | ||||
| Method | X-ray diffraction | Resolution | 1.52 Å | Mutation | No | [55] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LJ3 or .LJ32 or .LJ33 or :3LJ3;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid | Ligand Info | |||||
| Structure Description | Dual binding mode for 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid binding to Human transthyretin (TTR) | PDB:4TQ8 | ||||
| Method | X-ray diffraction | Resolution | 1.52 Å | Mutation | No | [45] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7BD or .7BD2 or .7BD3 or :37BD;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Genistein 7-O-glucuronide | Ligand Info | |||||
| Structure Description | Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: genistein-7-O- glucuronide | PDB:5AKV | ||||
| Method | X-ray diffraction | Resolution | 1.52 Å | Mutation | No | [49] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .G7G or .G7G2 or .G7G3 or :3G7G;style chemicals stick;color identity;select .A:15 or .A:16 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-(2,6-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with Benzoxazole | PDB:2F8I | ||||
| Method | X-ray diffraction | Resolution | 1.54 Å | Mutation | No | [58] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .205 or .2052 or .2053 or :3205;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3',5'-Difluorobiphenyl-4-carboxylic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with diflunisal analogues- TTR.3',5'-difluorobiphenyl-4-carboxylic acid | PDB:2B9A | ||||
| Method | X-ray diffraction | Resolution | 1.54 Å | Mutation | No | [59] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTARY105 TIAALLSPYS115 YSTTAVVT |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FBC or .FBC2 or .FBC3 or :3FBC;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2r)-3-[(9h-Fluoren-9-Ylideneamino)oxy]-2-Methyl-N-(Methylsulfonyl)propanamide | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with (R)-3-(9H-fluoren-9-ylideneaminooxy)-2-methyl-N-(methylsulfonyl) propionamide in a dual binding mode | PDB:4TQP | ||||
| Method | X-ray diffraction | Resolution | 1.58 Å | Mutation | No | [45] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .48R or .48R2 or .48R3 or :348R;style chemicals stick;color identity;select .A:15 or .A:17 or .A:24 or .A:51 or .A:52 or .A:53 or .A:54 or .A:106 or .A:108 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Triclopyr | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Transthyretin in Complex with 3,5,6-Trichloro-2-pyridinyloxyacetic acid (Triclopyr) | PDB:5L4M | ||||
| Method | X-ray diffraction | Resolution | 1.58 Å | Mutation | No | [4] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SBK or .SBK2 or .SBK3 or :3SBK;style chemicals stick;color identity;select .A:15 or .A:16 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (5Z)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-2-imino-1-methylimidazolidin-4-one | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with (Z)-5-(3,5-dibromo-4-hydroxybenzylidene)-imino-1-methylimidazolidin-4-one | PDB:3P3S | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [46] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3M2 or .3M22 or .3M23 or :33M2;style chemicals stick;color identity;select .A:15 or .A:17 or .A:64 or .A:65 or .A:66 or .A:98 or .A:99 or .A:100 or .A:101 or .A:102 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3,5,6-Trichloro-2-pyridinol | Ligand Info | |||||
| Structure Description | Crystal Structure Of Human Transthyretin in complex with 3,5,6-trichloro-2-pyridinol (TC2P) | PDB:6GRP | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [54] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .F4Z or .F4Z2 or .F4Z3 or :3F4Z;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-(2,6-Difluorophenyl)benzoic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with diflunisal analogues- TTR. 2',6'-Difluorobiphenyl-4-carboxylic Acid | PDB:2F7I | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [59] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .26C or .26C2 or .26C3 or :326C;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4,4'-Sulfonyldiphenol | Ligand Info | |||||
| Structure Description | Crystal Structure of Human Transthyretin in Complex with 4,4'-Dihydroxydiphenyl sulfone (Bisphenol S, BPS) | PDB:5L4J | ||||
| Method | X-ray diffraction | Resolution | 1.62 Å | Mutation | No | [4] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6JD or .6JD2 or .6JD3 or :36JD;style chemicals stick;color identity;select .A:15 or .A:17 or .A:24 or .A:52 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4'-{6-[4-(2-Carboxyphenylamino)-phenoxy]-hexyloxy}-biphenyl-4-carboxylic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (6 carbon linker) | PDB:2FLM | ||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | No | [57] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .6CA or .6CA2 or .6CA3 or :36CA;style chemicals stick;color identity;select .A:15 or .A:16 or .A:17 or .A:108 or .A:109 or .A:110 or .A:115 or .A:116 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-[(3,5-Dichloro-4-trioxidanylphenyl)amino]benzoic acid | Ligand Info | |||||
| Structure Description | transthyretin with tethered inhibitor on one monomer. | PDB:1U21 | ||||
| Method | X-ray diffraction | Resolution | 1.69 Å | Mutation | No | [60] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .P2C or .P2C2 or .P2C3 or :3P2C;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2',4'-Dichloro-4-hydroxy-1,1'-biphenyl-3-carboxylic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with Diflunisal analogues- TTR.2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACID | PDB:2B77 | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [59] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3CA or .3CA2 or .3CA3 or :33CA;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2',4'-Difluoro-4-hydroxy-5-iodo-1,1'-biphenyl-3-carboxylic acid | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with iododiflunisal | PDB:1Y1D | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [61] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FHI or .FHI2 or .FHI3 or :3FHI;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,4-Dinitrophenol | Ligand Info | |||||
| Structure Description | The crystal structure of 2,4-dinitrophenol in complex with human transthyretin | PDB:2B15 | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [62] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .DNF or .DNF2 or .DNF3 or :3DNF;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 2,6-dibromo-4-[(E)-2-(2,6-dichlorophenyl)ethenyl]phenol | Ligand Info | |||||
| Structure Description | Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dichlorostyryl)phenol | PDB:3IMR | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [52] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IW1 or .IW12 or .IW13 or :3IW1;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-[(3,5-Dichlorophenyl)amino]benzoic acid | Ligand Info | |||||
| Structure Description | Structure of human transthyretin complex with analgesic inhibitor | PDB:6D0W | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [63] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEQFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FQ7 or .FQ72 or .FQ73 or :3FQ7;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-[({(1e)-[2-(Trifluoromethyl)phenyl]methylidene}amino)oxy]propanoic Acid | Ligand Info | |||||
| Structure Description | Human Transthyretin (TTR) complexed with(E)-3-(2-(trifluoromethyl)benzylideneaminooxy)propanoic acid (inhibitor 11) | PDB:3GLZ | ||||
| Method | X-ray diffraction | Resolution | 1.78 Å | Mutation | No | [64] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1BD or .1BD2 or .1BD3 or :31BD;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,4,6-Tribromophenol | Ligand Info | |||||
| Structure Description | Structure of human transthyretin complexed with bromophenols: a new mode of binding | PDB:1E5A | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [65] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .TBP or .TBP2 or .TBP3 or :3TBP;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,6-Dibromo-4-phenoxyphenol | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) in complex with 1,3-Dibromo-2-hydroxy-5-phenoxybenzene | PDB:3CN3 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [55] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LJ4 or .LJ42 or .LJ43 or :3LJ4;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-({[(1Z)-(2-methoxyphenyl)methylidene]amino}oxy)propanoic acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with (E)-3-(2-methoxybenzylideneaminooxy)propanoic acid (inhibitor 13) | PDB:3GS7 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [64] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .8BD or .8BD2 or .8BD3 or :38BD;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-Hydroxy-4-phenoxybenzaldehyde | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17 | PDB:4ACT | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [66] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FT0 or .FT02 or .FT03 or :3FT0;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3-Methoxy-4-phenoxybenzoic acid | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-18 | PDB:4AC4 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [28] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .HKA or .HKA2 or .HKA3 or :3HKA;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2',3,3',4',5-Pentachlorobiphenyl-4-OL | Ligand Info | |||||
| Structure Description | Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-2',3,3',4',5-Pentachlorobiphenyl | PDB:2G9K | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [67] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NE1 or .NE12 or .NE13 or :3NE1;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3,3',4',5-Tetrachlorobiphenyl-4-OL | Ligand Info | |||||
| Structure Description | Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl | PDB:2GAB | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [67] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTANR103 RYTIAALLSP113 YSYSTTAVVT 123
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NE2 or .NE22 or .NE23 or :3NE2;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (R)-Sulindac | Ligand Info | |||||
| Structure Description | Crystal structure of wild-type human transthyretin in complex with sulindac | PDB:4IKK | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [68] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .SUZ or .SUZ2 or .SUZ3 or :3SUZ;style chemicals stick;color identity;select .A:15 or .A:16 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 2,2'-{undecane-1,11-Diylbis[oxy(3,5-Dichlorobenzene-4,1-Diyl)imino]}dibenzoic Acid | Ligand Info | |||||
| Structure Description | Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (11 carbon linker). | PDB:3IPB | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [42] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .JZD or .JZD2 or .JZD3 or :3JZD;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3,3'-Diiodo-L-thyronine | Ligand Info | |||||
| Structure Description | MECHANISM OF MOLECULAR RECOGNITION. STRUCTURAL ASPECTS OF 3,3'-DIIODO-L-THYRONINE BINDING TO HUMAN SERUM TRANSTHYRETIN | PDB:1THA | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [69] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEQFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNPKE
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .T33 or .T332 or .T333 or :3T33;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3',5'-Dinitro-N-acetyl-L-thyronine | Ligand Info | |||||
| Structure Description | TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3',5'-DINITRO-N-ACETYL-L-THYRONINE | PDB:2ROY | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [70] |
| PDB Sequence |
ESKCPLMVKV
16 LDAVRGSPAI26 NVAVHVFRKA36 ADDTWEPFAS46 GKTSESGELH56 GLTTEEEFVE 66 GIYKVEIDTK76 SYWKALGISP86 FHEHAEVVFT96 ANDSGPRRYT106 IAALLSPYSY 116 STTAVVTNPK126 E
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .P28 or .P282 or .P283 or :3P28;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Tetrac | Ligand Info | |||||
| Structure Description | Human transthyretin (also called prealbumin) complex with 3, 3',5,5'-tetraiodothyroacetic acid (t4ac) | PDB:1Z7J | ||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [71] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .T4A or .T4A2 or .T4A3 or :3T4A;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 3',5'-Dibromo-2',4,4',6'-Tetrahydroxy Aurone | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE DETERMINATION AT 2.3A OF HUMAN TRANSTHYRETIN-3',5'-DIBROMO-2',4,4',6-TETRA-HYDROXYAURONE COMPLEX | PDB:1THC | ||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [72] |
| PDB Sequence |
KCPLMVKVLD
18 AVRGSPAINV28 AVHVFRKAAD38 DTWEPFASGK48 TSESGELHGL58 TTEEQFVEGI 68 YKVEIDTKSY78 WKALGISPFH88 EHAEVVFTAN98 DSGPRRYTIA108 ALLSPYSYST 118 TAVVTNPK
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FL9 or .FL92 or .FL93 or :3FL9;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: {4-[4-(Hydroxymethyl)-2-Methoxyphenoxy]benzene-1,3-Diyl}bis[hydroxy(Oxo)ammonium] | Ligand Info | |||||
| Structure Description | Crystal Structure of Transthyretin in Complex With Ligand C-6 | PDB:4ABW | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [28] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .42M or .42M2 or .42M3 or :342M;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 5-(Chloromethyl)-2-(2,4-dichlorophenoxy)phenol | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-3 | PDB:4ABV | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [28] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FT2 or .FT22 or .FT23 or :3FT2;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-[(2',4'-Difluoro-4-hydroxy-5-iodobiphenyl-3-YL)carbonyl]-beta-alanine | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOH | PDB:3FCB | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [73] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IFB or .IFB2 or .IFB3 or :3IFB;style chemicals stick;color identity;select .A:15 or .A:17 or .A:52 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2,4-Dichloro-1-[4-(Chloromethyl)-2-Methoxyphenoxy]benzene | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-7 | PDB:4AC2 | ||||
| Method | X-ray diffraction | Resolution | 1.81 Å | Mutation | No | [28] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .43F or .43F2 or .43F3 or :343F;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Methyl N-[(2',4'-difluoro-4-hydroxy-5-iodobiphenyl-3-YL)carbonyl]-beta-alaninate | Ligand Info | |||||
| Structure Description | Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOMe | PDB:3FC8 | ||||
| Method | X-ray diffraction | Resolution | 1.85 Å | Mutation | No | [73] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IFA or .IFA2 or .IFA3 or :3IFA;style chemicals stick;color identity;select .A:15 or .A:17 or .A:24 or .A:52 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-(2,4-Dichlorophenoxy)-3-hydroxybenzaldehyde | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-2 | PDB:4ABU | ||||
| Method | X-ray diffraction | Resolution | 1.86 Å | Mutation | No | [28] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FT1 or .FT12 or .FT13 or :3FT1;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: n-(m-Trifluoromethylphenyl) phenoxazine-4,6-dicarboxylic acid | Ligand Info | |||||
| Structure Description | CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH N-(M-TRIFLUOROMETHYLPHENYL) PHENOXAZINE-4,6-DICARBOXYLIC ACID | PDB:1DVY | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [12] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEQFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BPD or .BPD2 or .BPD3 or :3BPD;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-Hydroxychalcone | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with 4-hydroxy-chalcone | PDB:5EZP | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [74] |
| PDB Sequence |
PLMVKVLDAV
20 RGSPAINVAV30 HVFRKAADDT40 WEPFASGKTS50 ESGELHGLTT60 EEEFVEGIYK 70 VEIDTKSYWK80 ALGISPFHEH90 AEVVFTANDS100 GPRRYTIAAL110 LSPYSYSTTA 120 VVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .IPJ or .IPJ2 or .IPJ3 or :3IPJ;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 5-Amino-1-naphthalenesulfonic acid | Ligand Info | |||||
| Structure Description | Crystal structure of human transthyretin in complex with 1-amino-5-naphthalene sulfonate | PDB:3CFT | ||||
| Method | X-ray diffraction | Resolution | 1.87 Å | Mutation | No | [13] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .5NS or .5NS2 or .5NS3 or :35NS;style chemicals stick;color identity;select .A:15 or .A:17 or .A:108 or .A:109 or .A:110 or .A:117; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: ({(Z)-[(3,4-Dichlorophenyl)(Phenyl)methylidene]amino}oxy)acetic Acid | Ligand Info | |||||
| Structure Description | Human transthyretin (TTR) complexed with (Z)-((3,4-Dichloro-phenyl)-methyleneaminooxy)-acetic acid | PDB:5E4O | ||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [32] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .L57 or .L572 or .L573 or :3L57;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: N-{4-[(E)-2-(4-Hydroxy-3,5-Dimethylphenyl)ethenyl]phenyl}ethanesulfonamide | Ligand Info | |||||
| Structure Description | Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide | PDB:4HJS | ||||
| Method | X-ray diffraction | Resolution | 1.22 Å | Mutation | No | [53] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .18J or .18J2 or .18J3 or :318J;style chemicals stick;color identity;select .A:15 or .A:17 or .A:52 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Rhenium | Ligand Info | |||||
| Structure Description | Human TTR altered by a rhenium tris-carbonyl Pyta-C8 derivative | PDB:5K1J | ||||
| Method | X-ray diffraction | Resolution | 1.69 Å | Mutation | No | [75] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .RE or .RE2 or .RE3 or :3RE;style chemicals stick;color identity;select .A:95 or .A:96; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [Bis(oxidanyl)-[tetrakis(oxidanyl)ferriooxy]ferrio]oxy-pentakis(oxidanyl)iron | Ligand Info | |||||
| Structure Description | Human TTR altered conformation from soaking in iron chloride. | PDB:5N5Q | ||||
| Method | X-ray diffraction | Resolution | 2.53 Å | Mutation | No | [76] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FFE or .FFE2 or .FFE3 or :3FFE;style chemicals stick;color identity;select .A:51; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-(1,3-Benzothiazol-2-yl)-2-methylaniline | Ligand Info | |||||
| Structure Description | Transthyretin in complex with 4-(1,3-Benzothiazol-2-yl)-2-methylaniline | PDB:6EOY | ||||
| Method | X-ray diffraction | Resolution | 1.38 Å | Mutation | No | [77] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BM8 or .BM82 or .BM83 or :3BM8;style chemicals stick;color identity;select .A:15 or .A:17 or .A:54 or .A:108 or .A:109 or .A:110 or .A:117 or .A:119; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (3-{(E)-2-[2-chloro-4-(hydroxyboranyl)phenyl]ethenyl}phenyl)boronic acid | Ligand Info | |||||
| Structure Description | Wild-type Transthyretin in complex with 2-Boronic Acid-1-[(1E)-2-(3-boronic acid)ethenyl]-4-chlorobenzene | PDB:5U4G | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [37] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTNP
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .7UV or .7UV2 or .7UV3 or :37UV;style chemicals stick;color identity;select .A:13 or .A:15 or .A:17 or .A:54 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 5-(4-nitrophenylazo)-3-iodosalicylic acid | Ligand Info | |||||
| Structure Description | Transthyretin in complex with 5-(4-nitrophenylazo)-3-iodosalicylic acid | PDB:6EP1 | ||||
| Method | X-ray diffraction | Resolution | 1.30 Å | Mutation | No | [78] |
| PDB Sequence |
CPLMVKVLDA
19 VRGSPAINVA29 VHVFRKAADD39 TWEPFASGKT49 SESGELHGLT59 TEEEFVEGIY 69 KVEIDTKSYW79 KALGISPFHE89 HAEVVFTAND99 SGPRRYTIAA109 LLSPYSYSTT 119 AVVTN
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set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BQB or .BQB2 or .BQB3 or :3BQB;style chemicals stick;color identity;select .A:15 or .A:17 or .A:106 or .A:108 or .A:109 or .A:110 or .A:117 or .A:118 or .A:119 or .A:121; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
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| REF 2 | Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity. Nat Commun. 2016 Feb 23;7:10787. | ||||
| REF 3 | The flavonoid luteolin, but not luteolin-7-O-glucoside, prevents a transthyretin mediated toxic response. PLoS One. 2015 May 28;10(5):e0128222. | ||||
| REF 4 | Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ Sci Technol. 2016 Nov 1;50(21):11984-11993. | ||||
| REF 5 | Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma. J Med Chem. 2015 Aug 27;58(16):6507-15. | ||||
| REF 6 | Crystal structure of the transthyretin--retinoic-acid complex. Eur J Biochem. 1995 Dec 1;234(2):563-9. | ||||
| REF 7 | The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors. J Biol Chem. 2004 Dec 17;279(51):53483-90. | ||||
| REF 8 | Crystal structure of human transthyretin variant A25T in complex with flufenamic acid. | ||||
| REF 9 | Structural aspects of inotropic bipyridine binding. Crystal structure determination to 1.9 A of the human serum transthyretin-milrinone complex. J Biol Chem. 1993 Mar 25;268(9):6202-6. | ||||
| REF 10 | Crystal structure of wild-type human transthyretin in complex with indomethacin | ||||
| REF 11 | Crystal structure of human transthyretin in complex with lumiracoxib | ||||
| REF 12 | Rational design of potent human transthyretin amyloid disease inhibitors. Nat Struct Biol. 2000 Apr;7(4):312-21. | ||||
| REF 13 | Identification of a novel ligand binding motif in the transthyretin channel. Bioorg Med Chem. 2010 Jan 1;18(1):100-10. | ||||
| REF 14 | Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution. J Mol Biol. 2001 Mar 2;306(4):733-44. | ||||
| REF 15 | Structural Variants of Transthyretin | ||||
| REF 16 | AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. | ||||
| REF 17 | Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding. J Struct Biol. 2010 Jun;170(3):522-31. | ||||
| REF 18 | Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J Struct Biol. 2019 Nov 1;208(2):165-173. | ||||
| REF 19 | Flavonoid interactions with human transthyretin: combined structural and thermodynamic analysis. J Struct Biol. 2012 Oct;180(1):143-53. | ||||
| REF 20 | The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition. J Struct Biol. 2011 Feb;173(2):323-32. | ||||
| REF 21 | Discovery of Gamma-Mangostin as an Amyloidogenesis Inhibitor. Sci Rep. 2015 Aug 27;5:13570. | ||||
| REF 22 | Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin. J Med Chem. 2014 Nov 13;57(21):8928-35. | ||||
| REF 23 | Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. Nat Chem Biol. 2010 Feb;6(2):133-9. | ||||
| REF 24 | Structural evidence for asymmetric ligand binding to transthyretin. Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1582-92. | ||||
| REF 25 | Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3441-3449. | ||||
| REF 26 | Iodination of salicylic acid improves its binding to transthyretin. Biochim Biophys Acta. 2008 Mar;1784(3):512-7. | ||||
| REF 27 | The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site. Biochemistry. 2010 Jul 27;49(29):6104-14. | ||||
| REF 28 | Crystallographic study of novel transthyretin ligands exhibiting negative-cooperativity between two thyroxine binding sites. PLoS One. 2012;7(9):e43522. | ||||
| REF 29 | Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol. 2015 Jan 25;32(1):54-64. | ||||
| REF 30 | Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer. Int J Mol Sci. 2020 Sep 28;21(19):7166. | ||||
| REF 31 | Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin. Bioorg Chem. 2020 Oct;103:104144. | ||||
| REF 32 | Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR). J Enzyme Inhib Med Chem. 2016;31(sup1):40-51. | ||||
| REF 33 | Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg Med Chem. 2021 Aug 15;44:116292. | ||||
| REF 34 | Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione. J Pharmacol Sci. 2015 Dec;129(4):240-3. | ||||
| REF 35 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J Med Chem. 2019 Feb 28;62(4):2076-2082. | ||||
| REF 36 | Crystal structures of human transthyretin complexed with glabridin. J Med Chem. 2014 Feb 13;57(3):1090-6. | ||||
| REF 37 | Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. J Med Chem. 2017 Sep 28;60(18):7820-7834. | ||||
| REF 38 | Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis. Bioorg Med Chem. 2020 Sep 15;28(18):115673. | ||||
| REF 39 | Boronic acid with high oxidative stability and utility in biological contexts. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2013691118. | ||||
| REF 40 | Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chem Commun (Camb). 2013 Oct 14;49(80):9188-9190. | ||||
| REF 41 | Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging--what we know and what we need to learn. Biopolymers. 2014 May;101(5):484-95. | ||||
| REF 42 | Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20483-8. | ||||
| REF 43 | High Resolution Structure of Wild Type Human Transthyretin in Complex with 3,3',5,5'-tetrachloro-[1,1'-biphenyl]-4,4'diol | ||||
| REF 44 | Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate. J Am Chem Soc. 2013 Apr 17;135(15):5656-68. | ||||
| REF 45 | X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem. 2016 Oct;31(5):824-33. | ||||
| REF 46 | Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med. 2011 Aug 24;3(97):97ra81. | ||||
| REF 47 | A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans. J Am Chem Soc. 2015 Jun 17;137(23):7404-14. | ||||
| REF 48 | Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity. PLoS One. 2016 Apr 6;11(4):e0153112. | ||||
| REF 49 | Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites. J Biol Chem. 2015 Dec 11;290(50):29769-80. | ||||
| REF 50 | Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. J Med Chem. 2008 Jan 24;51(2):260-70. | ||||
| REF 51 | Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J Med Chem. 2009 Feb 26;52(4):1115-25. | ||||
| REF 52 | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. J Am Chem Soc. 2010 Feb 3;132(4):1359-70. | ||||
| REF 53 | Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J Am Chem Soc. 2013 Nov 27;135(47):17869-80. | ||||
| REF 54 | Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals. Environ Sci Technol. 2018 Oct 16;52(20):11865-11874. | ||||
| REF 55 | Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J Med Chem. 2008 Oct 23;51(20):6348-58. | ||||
| REF 56 | Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer. PLoS One. 2016 Apr 19;11(4):e0153529. | ||||
| REF 57 | Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. J Am Chem Soc. 2003 Nov 5;125(44):13404-14. | ||||
| REF 58 | Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action. Angew Chem Int Ed Engl. 2003 Jun 23;42(24):2758-61. | ||||
| REF 59 | Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J Med Chem. 2004 Jan 15;47(2):355-74. | ||||
| REF 60 | Kinetic stabilization of an oligomeric protein by a single ligand binding event. J Am Chem Soc. 2005 Apr 20;127(15):5540-51. | ||||
| REF 61 | Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor. Biochem J. 2005 Jun 1;388(Pt 2):615-21. | ||||
| REF 62 | The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin. Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):512-9. | ||||
| REF 63 | Structural Analysis of Human Transthyretin Analgesic Inhibitor Complex | ||||
| REF 64 | Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis. PLoS One. 2009 Jul 21;4(7):e6290. | ||||
| REF 65 | Structure of human transthyretin complexed with bromophenols: a new mode of binding. Acta Crystallogr D Biol Crystallogr. 2000 Sep;56(Pt 9):1085-95. | ||||
| REF 66 | Crystallographic Study of Novel Transthyretin Inhibitors: Unique Mechanism of Negative-Cooperativity between Two T4 Binding Sites | ||||
| REF 67 | Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chem Biol. 2004 Dec;11(12):1719-28. | ||||
| REF 68 | Crystal structure of wild-type human transthyretin in complex with sulindac | ||||
| REF 69 | Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin. J Biol Chem. 1992 Jan 5;267(1):353-7. | ||||
| REF 70 | Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution. Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):758-65. | ||||
| REF 71 | Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution. Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1313-9. | ||||
| REF 72 | Crystal structure determination at 2.3-A resolution of human transthyretin-3',5'-dibromo-2',4,4',6-tetrahydroxyaurone complex. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6644-8. | ||||
| REF 73 | Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. PLoS One. 2009;4(1):e4124. | ||||
| REF 74 | A new crystal form of human transthyretin obtained with a curcumin derived ligand. J Struct Biol. 2016 Apr;194(1):8-17. | ||||
| REF 75 | Human TTR conformation altered by rhenium tris-carbonyl derivatives. J Struct Biol. 2016 Sep;195(3):353-364. | ||||
| REF 76 | Copper mediated amyloid-beta binding to Transthyretin. Sci Rep. 2018 Sep 13;8(1):13744. | ||||
| REF 77 | Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease. Eur J Med Chem. 2021 Dec 15;226:113847. | ||||
| REF 78 | Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease. doi:10.1016/j.ejmech.2021.113847. | ||||
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