Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04AIT
|
|||
| Former ID |
DAP001461
|
|||
| Drug Name |
B-Lactams
|
|||
| Synonyms |
Luteolin; luteolin; 491-70-3; Luteolol; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; Luteoline; Digitoflavone; Flacitran; Weld Lake; Cyanidenon 1470; Salifazide; Yama kariyasu; 5,7,3',4'-Tetrahydroxyflavone; UNII-KUX1ZNC9J2; CI Natural Yellow 2; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-; 7-Tetrahydroxyflavone; CCRIS 3790; EINECS 207-741-0; KUX1ZNC9J2; CHEMBL151; BRN 0292084; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C15H10O6
|
|||
| Canonical SMILES |
C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O
|
|||
| InChI |
1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
|
|||
| InChIKey |
IQPNAANSBPBGFQ-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 491-70-3
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
4680, 597187, 7429738, 8145650, 8616273, 10318976, 10321223, 11108250, 11112366, 11112367, 11466898, 11468018, 11486576, 12015086, 14897817, 24896520, 25622156, 26725303, 26754151, 26754152, 26759067, 29204349, 39289568, 46500347, 47216891, 47291243, 47589108, 47589109, 48035258, 48035259, 48259375, 48259376, 48334626, 49698673, 49970086, 50124086, 50124087, 50979249, 53790299, 53800709, 56369288, 56463543, 57357740, 60766863, 74380610, 81041194, 85256900, 85279365, 85788780, 87561546
|
|||
| ChEBI ID |
CHEBI:15864
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetyl-CoA:lyso-PAF acetyltransferase (PCAT) | Target Info | Inhibitor | [2] |
| Bacterial DD-carboxypeptidase (Bact vanYB) | Target Info | Inhibitor | [1] | |
| DNA topoisomerase I (TOP1) | Target Info | Inhibitor | [3] | |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | DNA replication | |||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92. | |||
| REF 2 | Inhibition of lysoPAF acetyltransferase activity by flavonoids. Inflamm Res. 1996 Nov;45(11):546-9. | |||
| REF 3 | Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J. 2002 Sep 1;366(Pt 2):653-61. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.