Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86462 | Target Info | |||
| Target Name | Transthyretin (TTR) | ||||
| Synonyms | TBPA; Prealbumin; PALB; ATTR | ||||
| Target Type | Successful Target | ||||
| Gene Name | TTR | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | PMID26560530-Compound-23 | Ligand Info | |||
| Canonical SMILES | COC1=C(C=CC(=C1)C=CC(=CC(=O)C=CC2=CC(=C(C=C2)O)OC)O)O | ||||
| InChI | 1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,22,24-25H,1-2H3/b7-3+,8-4+,16-13- | ||||
| InChIKey | ZIUSSTSXXLLKKK-KOBPDPAPSA-N | ||||
| PubChem Compound ID | 5281767 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 4PME Human transthyretin (TTR) complexed with ferulic acid and curcumin. | ||||||
| Method | X-ray diffraction | Resolution | 1.26 Å | Mutation | No | [1] |
| PDB Sequence |
KCPLMVKVLD
18 AVRGSPAINV28 AVHVFRKAAD38 DTWEPFASGK48 TSESGELHGL58 TTEEEFVEGI 68 YKVEIDTKSY78 WKALGISPFH88 EHAEVVFTAN98 DSGPRRYTIA108 ALLSPYSYST 118 TAVVTNP
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| PDB ID: 4PMF Human transthyretin (TTR) complexed with curcumin | ||||||
| Method | X-ray diffraction | Resolution | 1.35 Å | Mutation | No | [1] |
| PDB Sequence |
KCPLMVKVLD
18 AVRGSPAINV28 AVHVFRKAAD38 DTWEPFASGK48 TSESGELHGL58 TTEEEFVEGI 68 YKVEIDTKSY78 WKALGISPFH88 EHAEVVFTAN98 DSGPRRYTIA108 ALLSPYSYST 118 TAVVTNP
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol. 2015 Jan 25;32(1):54-64. | ||||
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