Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | Myeloid differentiation primary response protein MyD88 (MYD88) | Literature-reported | Target Info | ||
UniProt ID | MYD88_HUMAN | ||||
Gene Name | MYD88 | ||||
Gene ID | 4615 |
Interacting TTD Target Information | Top | ||||
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Interacting Clinical trial Target(s) | Toll-like receptor 4 (TLR4) | Target Info | PPI Info | [1] | |
Renal carcinoma antigen NY-REN-64 (IRAK-4) | Target Info | PPI Info | [2] | ||
Interacting Patented-recorded Target(s) | IL-1 receptor-associated kinase 1 (IRAK1) | Target Info | PPI Info | [3] | |
Toll/interleukin-1 receptor domain-containing adapter (TIRAP) | Target Info | PPI Info | [5] | ||
Interacting Literature-reported Target(s) | Myeloid differentiation primary response protein MyD88 (MYD88) | Target Info | PPI Info | [4] | |
TNF receptor-associated factor 6 (TRAF6) | Target Info | PPI Info | [3] |
References | Top | ||||
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REF 1 | Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. J Biol Chem. 2000 Nov 3;275(44):34035-40. | ||||
REF 2 | Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med. 2003 Jan 20;197(2):263-8. | ||||
REF 3 | A20-binding inhibitor of NF-B (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein activation and protects from inflammatory disease. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E998-1006. | ||||
REF 4 | Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. J Leukoc Biol. 2007 Oct;82(4):801-10. | ||||
REF 5 | Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site. J Cell Sci. 2010 Jan 15;123(Pt 2):256-65. |
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