Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T43814 Target Info
Target Name Toll/interleukin-1 receptor domain-containing adapter (TIRAP)
Synonyms Toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein; MyD88-2; MyD88 adapter-like protein; MAL; Adaptor protein Wyatt
Target Type Patented-recorded Target
Gene Name TIRAP
UniProt ID
TIRAP_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name Myeloid differentiation primary response protein MyD88 (MYD88) Literature-reported Target Interacting Protein Info
UniProt ID
MYD88_HUMAN 
Synonyms MyD88
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Protein-Fragment Complementation Assay [2]
3 Protein-Fragment Complementation Assay [3]
4 Protein-Fragment Complementation Assay [1]
5 Yeast two hybrid [4]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Toll-like receptor 4 (TLR4) Clinical trial Target Interacting Protein Info
UniProt ID
TLR4_HUMAN 
Synonyms TLR-4; HToll; CD284
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [4]
4 Reconstituted Complex [6]
Kinases [+] 1 Kinases +
Interacting Protein Name Interleukin-1 receptor-associated kinase-like 2 (IRAK2) Interacting Protein Interacting Protein Info
UniProt ID
IRAK2_HUMAN 
Synonyms IRAK.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-Western [4]
References  Top
REF 1 Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site. J Cell Sci. 2010 Jan 15;123(Pt 2):256-65.
REF 2 MAPPIT analysis of TLR adaptor complexes. FEBS Lett. 2007 Feb 20;581(4):629-36.
REF 3 MAPPIT analysis of early Toll-like receptor signalling events. Immunol Lett. 2008 Mar 15;116(2):141-8.
REF 4 Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83.
REF 5 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 6 TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol. 2001 Sep;2(9):835-41.

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