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| Protein General Information |
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| Full Name |
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)
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| UniProt ID |
IRAK2_HUMAN
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| Gene Name |
IRAK2
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| Gene ID |
3656
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| Interacting TTD Target Information |
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| Interacting Patented-recorded Target(s) |
IL-1 receptor-associated kinase 1 (IRAK1) |
Target Info
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PPI Info
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[1] |
| Toll/interleukin-1 receptor domain-containing adapter (TIRAP) |
Target Info
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PPI Info
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[3] |
| Interacting Literature-reported Target(s) |
Myeloid differentiation primary response protein MyD88 (MYD88) |
Target Info
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PPI Info
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[2] |
| TNF receptor-associated factor 6 (TRAF6) |
Target Info
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PPI Info
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[4] |
| References |
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| REF 1 |
Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. J Biol Chem. 2002 Oct 4;277(40):37414-21.
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| REF 2 |
A20-binding inhibitor of NF-B (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein activation and protects from inflammatory disease. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E998-1006.
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| REF 3 |
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83.
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| REF 4 |
IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination. J Biol Chem. 2007 Nov 16;282(46):33435-43.
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