Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T75476 Target Info
Target Name Myeloid differentiation primary response protein MyD88 (MYD88)
Synonyms MyD88
Target Type Literature-reported Target
Gene Name MYD88
UniProt ID
MYD88_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [2]
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name Toll/interleukin-1 receptor domain-containing adapter (TIRAP) Patented-recorded Target Interacting Protein Info
UniProt ID
TIRAP_HUMAN 
Synonyms Toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein; MyD88-2; MyD88 adapter-like protein; MAL; Adaptor protein Wyatt
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Protein-Fragment Complementation Assay [5]
4 Protein-Fragment Complementation Assay [6]
5 Yeast two hybrid [3]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Toll-like receptor 4 (TLR4) Clinical trial Target Interacting Protein Info
UniProt ID
TLR4_HUMAN 
Synonyms TLR-4; HToll; CD284
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Protein-Fragment Complementation Assay [8]
3 Reconstituted Complex [9]
Kinases [+] 3 Kinases +
Interacting Target Name IL-1 receptor-associated kinase 1 (IRAK1) Patented-recorded Target Interacting Protein Info
UniProt ID
IRAK1_HUMAN 
Synonyms IRAK-1; IRAK; Interleukin-1 receptor-associated kinase 1
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [10]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [12]
5 Affinity Capture-Western [13]
6 Affinity Capture-Western [14]
7 Affinity Capture-Western [15]
8 Affinity Capture-Western [16]
9 Affinity Capture-Western [17]
10 Affinity Capture-Western [18]
Interacting Target Name Renal carcinoma antigen NY-REN-64 (IRAK-4) Clinical trial Target Interacting Protein Info
UniProt ID
IRAK4_HUMAN 
Synonyms Renal carcinoma antigenNYREN64; Renal carcinoma antigen NY-REN-64; NY-REN-64 antigen; IRAK-4; Interleukin-1 receptor-associated kinase 4; Interleukin1 receptorassociated kinase 4
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
3 Affinity Capture-Western [13]
4 Affinity Capture-Western [17]
5 Protein-Fragment Complementation Assay [8]
6 Yeast two hybrid [14]
7 Yeast two hybrid [19]
8 Yeast two hybrid [20]
Interacting Protein Name Interleukin-1 receptor-associated kinase-like 2 (IRAK2) Interacting Protein Interacting Protein Info
UniProt ID
IRAK2_HUMAN 
Synonyms IRAK.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [15]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Interferon regulatory factor 7 (IRF7) Interacting Protein Interacting Protein Info
UniProt ID
IRF7_HUMAN 
Synonyms IRF.7H; IRF7A; IRF7B; IRF7C; IRF7H
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Affinity Capture-Western [22]
3 Fluorescence Resonance Energy Transfer [22]
4 Yeast two hybrid [22]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Speckle-type POZ protein (SPOP) Interacting Protein Interacting Protein Info
UniProt ID
SPOP_HUMAN 
Synonyms BTBD32; TEF2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Affinity Capture-MS [24]
3 Affinity Capture-Western [25]
4 Yeast two hybrid [26]
5 Yeast two hybrid [25]
References  Top
REF 1 A20-binding inhibitor of NF-B (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein activation and protects from inflammatory disease. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E998-1006.
REF 2 UBE2O negatively regulates TRAF6-mediated NF-B activation by inhibiting TRAF6 polyubiquitination. Cell Res. 2013 Mar;23(3):366-77.
REF 3 Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83.
REF 4 A Pseudomonas aeruginosaIR effector mediates immune evasion by targetingBAP1 and TLR adaptors. EMBO J. 2017 Jul 3;36(13):1869-1887.
REF 5 MAPPIT analysis of TLR adaptor complexes. FEBS Lett. 2007 Feb 20;581(4):629-36.
REF 6 Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site. J Cell Sci. 2010 Jan 15;123(Pt 2):256-65.
REF 7 Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. J Biol Chem. 2000 Nov 3;275(44):34035-40.
REF 8 MAPPIT analysis of early Toll-like receptor signalling events. Immunol Lett. 2008 Mar 15;116(2):141-8.
REF 9 Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J Immunol. 2003 Apr 1;170(7):3565-71.
REF 10 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 11 Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88. J Biol Chem. 2002 Jul 5;277(27):24169-79.
REF 12 A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol Cell Biol. 2005 Aug;25(15):6521-32.
REF 13 IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72.
REF 14 Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med. 2003 Jan 20;197(2):263-8.
REF 15 IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem. 1999 Jul 2;274(27):19403-10.
REF 16 Constitutive association of MyD88 to IRAK in HTLV-I-transformed T cells. Exp Hematol. 2007 Dec;35(12):1812-22.
REF 17 Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. J Leukoc Biol. 2007 Oct;82(4):801-10.
REF 18 Bacterial lipoprotein-induced self-tolerance and cross-tolerance to LPS are associated with reduced IRAK-1 expression and MyD88-IRAK complex format... J Leukoc Biol. 2006 Apr;79(4):867-75.
REF 19 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 20 Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015 Apr 23;161(3):647-660.
REF 21 IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. J Biol Chem. 2006 Apr 14;281(15):10073-80.
REF 22 Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004 Oct;5(10):1061-8.
REF 23 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 24 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 25 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 26 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.

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