Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T63846 Target Info
Target Name IL-1 receptor-associated kinase 1 (IRAK1)
Synonyms Interleukin-1 receptor-associated kinase 1; IRAK-1; IRAK
Target Type Patented-recorded Target
Gene Name IRAK1
Biochemical Class Kinase
UniProt ID
IRAK1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 3 Acyltransferases +
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 18 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [6]
7 Affinity Capture-Western [7]
8 Affinity Capture-Western [8]
9 Affinity Capture-Western [9]
10 Affinity Capture-Western [10]
11 Affinity Capture-Western [11]
12 Affinity Capture-Western [12]
13 Affinity Capture-Western [13]
14 Affinity Capture-Western [14]
15 Affinity Capture-Western [15]
16 Biochemical Activity [16]
17 Reconstituted Complex [17]
18 Yeast two hybrid [18]
Interacting Protein Name E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) Interacting Protein Interacting Protein Info
UniProt ID
PELI1_HUMAN 
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [19]
3 Biochemical Activity [20]
4 Biochemical Activity [21]
5 Biochemical Activity [22]
Interacting Protein Name E3 ubiquitin-protein ligase pellino homolog 2 (PELI2) Interacting Protein Interacting Protein Info
UniProt ID
PELI2_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [23]
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name Myeloid differentiation primary response protein MyD88 (MYD88) Literature-reported Target Interacting Protein Info
UniProt ID
MYD88_HUMAN 
Synonyms MyD88
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-Western [25]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Interleukin 1 receptor type 1 (IL1R1) Successful Target Interacting Protein Info
UniProt ID
IL1R1_HUMAN 
Synonyms p80; Interleukin-1 receptor type I; Interleukin-1 receptor type 1; Interleukin-1 receptor alpha; IL-1RT-1; IL-1RT1; IL1RT1; IL-1R-alpha; IL1RA; IL-1R-1; IL-1R; IL1R; CD121a; CD121 antigen-like family member A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Co-purification [27]
Kinases [+] 3 Kinases +
Interacting Target Name Renal carcinoma antigen NY-REN-64 (IRAK-4) Clinical trial Target Interacting Protein Info
UniProt ID
IRAK4_HUMAN 
Synonyms Renal carcinoma antigenNYREN64; Renal carcinoma antigen NY-REN-64; NY-REN-64 antigen; IRAK-4; Interleukin-1 receptor-associated kinase 4; Interleukin1 receptorassociated kinase 4
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [28]
2 Affinity Capture-Western [29]
3 Biochemical Activity [30]
4 Protein-Fragment Complementation Assay [31]
5 Yeast two hybrid [23]
Interacting Target Name IL-1 receptor-associated kinase 3 (IRAK3) Literature-reported Target Interacting Protein Info
UniProt ID
IRAK3_HUMAN 
Synonyms IRAK-M; IRAK-3; Interleukin-1 receptor-associated kinase 3; IL-1 receptor-associated kinase M
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Fluorescence Resonance Energy Transfer [32]
Interacting Protein Name Interleukin-1 receptor-associated kinase-like 2 (IRAK2) Interacting Protein Interacting Protein Info
UniProt ID
IRAK2_HUMAN 
Synonyms IRAK.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [28]
2 Fluorescence Resonance Energy Transfer [32]
References  Top
REF 1 IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J Biol Chem. 2001 Nov 9;276(45):41661-7.
REF 2 Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J Biol Chem. 2011 Mar 11;286(10):7905-16.
REF 3 Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol. 2002 Oct;22(20):7158-67.
REF 4 A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol Cell Biol. 2005 Aug;25(15):6521-32.
REF 5 Regulation of IRAK-1 activation by its C-terminal domain. Cell Signal. 2009 May;21(5):719-26.
REF 6 Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. Nat Immunol. 2006 Oct;7(10):1057-65.
REF 7 Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. J Biol Chem. 2004 Feb 13;279(7):5227-36.
REF 8 T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72.
REF 9 IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4461-5.
REF 10 RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex. FEBS Lett. 2010 Feb 19;584(4):662-8.
REF 11 Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling. Biochim Biophys Acta. 2009 Dec;1790(12):1673-80.
REF 12 Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity. J Immunol. 2007 Sep 15;179(6):4125-34.
REF 13 PINK1 positively regulates IL-1-mediated signaling through Tollip and IRAK1 modulation. J Neuroinflammation. 2012 Dec 17;9:271.
REF 14 UBE2O negatively regulates TRAF6-mediated NF-B activation by inhibiting TRAF6 polyubiquitination. Cell Res. 2013 Mar;23(3):366-77.
REF 15 Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling. J Biol Chem. 2017 Oct 20;292(42):17250-17257.
REF 16 Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. Mol Cell Biol. 2008 May;28(10):3538-47.
REF 17 TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia. J Biol Chem. 2012 May 11;287(20):16132-45.
REF 18 Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol Cell Biol. 2001 Apr;21(7):2475-84.
REF 19 Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases. FEBS Lett. 2006 Aug 21;580(19):4697-702.
REF 20 The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. Biochem J. 2008 Jan 1;409(1):43-52.
REF 21 Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4584-90.
REF 22 The role of TBK1 and IKK in the expression and activation of Pellino 1. Biochem J. 2011 Mar 15;434(3):537-48.
REF 23 Characterization of Pellino2, a substrate of IRAK1 and IRAK4. FEBS Lett. 2003 Jul 17;547(1-3):157-61.
REF 24 A20-binding inhibitor of NF-B (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein activation and protects from inflammatory disease. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E998-1006.
REF 25 Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88. J Biol Chem. 2002 Jul 5;277(27):24169-79.
REF 26 Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR . J Biol Chem. 2003 May 9;278(19):16713-9.
REF 27 IRAK: a kinase associated with the interleukin-1 receptor. Science. 1996 Feb 23;271(5252):1128-31.
REF 28 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 29 Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med. 2003 Jan 20;197(2):263-8.
REF 30 IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72.
REF 31 MAPPIT analysis of early Toll-like receptor signalling events. Immunol Lett. 2008 Mar 15;116(2):141-8.
REF 32 Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. J Biol Chem. 2002 Oct 4;277(40):37414-21.

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