Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T55398 Target Info
Target Name Renal carcinoma antigen NY-REN-64 (IRAK-4)
Synonyms Interleukin-1 receptor-associated kinase 4; IRAK-4
Target Type Clinical trial Target
Gene Name IRAK4
Biochemical Class Kinase
UniProt ID
IRAK4_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase pellino homolog 2 (PELI2) Interacting Protein Interacting Protein Info
UniProt ID
PELI2_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Yeast two hybrid [2]
Interacting Protein Name E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) Interacting Protein Interacting Protein Info
UniProt ID
PELI1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [3]
Adapter proteins [+] 1 Adapter proteins +
Interacting Target Name Myeloid differentiation primary response protein MyD88 (MYD88) Literature-reported Target Interacting Protein Info
UniProt ID
MYD88_HUMAN 
Synonyms MyD88
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Protein-Fragment Complementation Assay [5]
3 Yeast two hybrid [2]
Kinases [+] 1 Kinases +
Interacting Target Name IL-1 receptor-associated kinase 1 (IRAK1) Patented-recorded Target Interacting Protein Info
UniProt ID
IRAK1_HUMAN 
Synonyms IRAK-1; IRAK; Interleukin-1 receptor-associated kinase 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [4]
3 Biochemical Activity [7]
4 Protein-Fragment Complementation Assay [5]
5 Yeast two hybrid [2]
References  Top
REF 1 Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. J Biol Chem. 2007 Oct 12;282(41):29729-37.
REF 2 Characterization of Pellino2, a substrate of IRAK1 and IRAK4. FEBS Lett. 2003 Jul 17;547(1-3):157-61.
REF 3 The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. Biochem J. 2008 Jan 1;409(1):43-52.
REF 4 Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med. 2003 Jan 20;197(2):263-8.
REF 5 MAPPIT analysis of early Toll-like receptor signalling events. Immunol Lett. 2008 Mar 15;116(2):141-8.
REF 6 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 7 IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.