Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T81443 Target Info
Target Name Toll-like receptor 4 (TLR4)
Synonyms TLR-4; HToll; CD284
Target Type Clinical trial Target
Gene Name TLR4
Biochemical Class Toll-like receptor
UniProt ID
TLR4_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 2 Adapter proteins +
Interacting Target Name Myeloid differentiation primary response protein MyD88 (MYD88) Literature-reported Target Interacting Protein Info
UniProt ID
MYD88_HUMAN 
Synonyms MyD88
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Protein-Fragment Complementation Assay [4]
5 Protein-Fragment Complementation Assay [5]
6 Reconstituted Complex [6]
Interacting Target Name Toll/interleukin-1 receptor domain-containing adapter (TIRAP) Patented-recorded Target Interacting Protein Info
UniProt ID
TIRAP_HUMAN 
Synonyms Toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein; MyD88-2; MyD88 adapter-like protein; MAL; Adaptor protein Wyatt
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [2]
3 Protein-Fragment Complementation Assay [2]
4 Protein-Fragment Complementation Assay [4]
5 Protein-Fragment Complementation Assay [5]
6 Reconstituted Complex [8]
Other proteins [+] 1 Other proteins +
Interacting Protein Name TIR domain-containing adapter molecule 2 (TICAM2) Interacting Protein Interacting Protein Info
UniProt ID
TCAM2_HUMAN 
Synonyms MyD88.4; TICAM.2; TIRAP3; TIRP; TRAM
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Protein-Fragment Complementation Assay [2]
3 Protein-Fragment Complementation Assay [4]
References  Top
REF 1 Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. J Biol Chem. 2000 Nov 3;275(44):34035-40.
REF 2 MAPPIT analysis of TLR adaptor complexes. FEBS Lett. 2007 Feb 20;581(4):629-36.
REF 3 E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}. J Exp Med. 2011 Sep 26;208(10):2099-112.
REF 4 MAPPIT analysis of early Toll-like receptor signalling events. Immunol Lett. 2008 Mar 15;116(2):141-8.
REF 5 Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site. J Cell Sci. 2010 Jan 15;123(Pt 2):256-65.
REF 6 Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J Immunol. 2003 Apr 1;170(7):3565-71.
REF 7 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 8 TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol. 2001 Sep;2(9):835-41.
REF 9 WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO Rep. 2015 Apr;16(4):447-55.

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