Target Validation Information
Target ID T60529
Target Name Prostaglandin G/H synthase 1
Target Type
Successful
Drug Potency against Target L-745337 Drug Info IC50 = 1600 nM [1]
Suprofen Drug Info IC50 = 0.136 uM [2]
2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one Drug Info IC50 = 18000 nM [3]
Prifelone Drug Info IC50 = 500 nM [4]
2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one Drug Info IC50 = 13000 nM [3]
2-Methyl-1,2-dihydro-indazol-3-one Drug Info IC50 = 17000 nM [3]
2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one Drug Info IC50 = 3800 nM [3]
2-(2-Methylpropanoyl)-1,3,5-benzenetriol Drug Info IC50 = 3800 nM [5]
(11H-Dibenzo[b,e][1,4]dioxepin-2-yl)-acetic acid Drug Info IC50 = 100 nM [6]
HONOKIOL Drug Info IC50 = 1800 nM [7]
Mesalazine Drug Info IC50 = 50~1000 nM [8]
1-(4-aminosulfonylphenyl)-2-(2-pyridyl)acetylene Drug Info IC50 = 9300 nM [9]
1-(4-aminosulfonylphenyl)-2-(4-pyridyl)acetylene Drug Info IC50 = 3900 nM [9]
CIMICOXIB Drug Info IC50 = 1900 nM [10]
2-(3'-Vinyl-biphenyl-4-yl)-propionic acid Drug Info IC50 = 1300 nM [11]
Acetic acid 2-hept-2-ynylsulfanyl-phenyl ester Drug Info IC50 = 17000 nM [12]
TENIDAP Drug Info IC50 = 2560 nM [13]
2-(3'-Allyl-biphenyl-4-yl)-propionic acid Drug Info IC50 = 1400 nM [11]
5,3'-Dipropyl-biphenyl-2,4'-diol Drug Info IC50 = 800 nM [7]
IODOINDOMETHACIN Drug Info IC50 = 780 nM [14]
Icosapent Drug Info IC50 = 13000 nM [15]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl Drug Info IC50 = 11400 nM [7]
4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiole-3-thione Drug Info IC50 = 30 nM [16]
4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one Drug Info IC50 = 0.3 nM [16]
5-(4-Chlorophenyl)-4-p-tolyl-1,2-selenazole Drug Info IC50 = 200 nM [17]
5-(4-Chlorophenyl)-4-(4-methoxyphenyl)isothiazole Drug Info IC50 = 70 nM [16]
Acetic acid 2-hexylsulfanyl-phenyl ester Drug Info IC50 = 8000 nM [12]
4-(4-Chlorophenyl)-5-(4-methoxyphenyl)isothiazole Drug Info IC50 = 20 nM [16]
2-(3'-Ethylsulfanyl-biphenyl-4-yl)-propionic acid Drug Info IC50 = 3100 nM [11]
2-[4-(1H-Indol-5-yl)-phenyl]-propionic acid Drug Info IC50 = 100 nM [11]
Acetic acid 2-hex-2-ynylsulfanyl-phenyl ester Drug Info IC50 = 14000 nM [12]
2-(2-(2,6-dimethylphenylamino)phenyl)acetic acid Drug Info IC50 = 234 nM [18]
1-(4-(methylsulfonyl)phenyl)-3-phenylurea Drug Info IC50 = 9200 nM [19]
2-(3'-Ethyl-biphenyl-4-yl)-propionic acid Drug Info IC50 = 5800 nM [11]
2-Phenethyl-1,2-dihydro-indazol-3-one Drug Info IC50 = 15000 nM [3]
4,5-Bis(4-methoxyphenyl)-1,2-selenazole Drug Info IC50 = 6 nM [17]
4,5-Bis(4-methoxyphenyl)isothiazole Drug Info IC50 = 3 nM [16]
2-(N-(2-Ffuorophenyl)pyrrol-3-yl) acetic acid Drug Info IC50 = 10600 nM [20]
Acetic acid 2-heptylselanyl-phenyl ester Drug Info IC50 = 12000 nM [12]
Acetic acid 2-pentylsulfanyl-phenyl ester Drug Info IC50 = 5000 nM [12]
(11H-Dibenzo[b,e][1,4]dioxepin-8-yl)-acetic acid Drug Info IC50 = 10000 nM [6]
4-(4-Chlorophenyl)-5-p-tolylisothiazole Drug Info IC50 = 200 nM [16]
4-(5-(4-Hydroxyphenyl)isothiazol-4-yl)phenol Drug Info IC50 = 1000 nM [16]
5-(4-Chlorophenyl)-4-p-tolylisothiazole Drug Info IC50 = 40 nM [16]
5-(2-1H-indenyl)-1,3-benzodioxole Drug Info IC50 = 12800 nM [21]
2-Benzyl-1,2-dihydro-indazol-3-one Drug Info IC50 = 18000 nM [3]
Acetic acid 2-hept-3-ynylsulfanyl-phenyl ester Drug Info IC50 = 18000 nM [12]
N-(3-phenoxy-4-pyridinyl)ethanesulfonamide Drug Info IC50 = 5340 nM [22]
4-amino-N-(4-chlorophenyl)benzenesulfonamide Drug Info IC50 = 12000 nM [23]
N-(3-phenoxy-4-pyridinyl)propanesulfonamide Drug Info IC50 = 18360 nM [22]
DOCOSAHEXAENOIC ACID Drug Info IC50 = 15000 nM [15]
4-(4-Chlorophenyl)-5-p-tolyl-1,2-selenazole Drug Info IC50 = 50 nM [17]
5-Methyl-3,4-diphenyl-isoxazole Drug Info IC50 = 90 nM [24]
5-(4-Chlorophenyl)-4-p-tolyl-3H-1,2-dithiol-3-one Drug Info IC50 = 200 nM [16]
4-(4-Chlorophenyl)-5-p-tolyl-3H-1,2-dithiol-3-one Drug Info IC50 = 20 nM [16]
2-(2-methoxyphenyl)-1H-indene Drug Info IC50 = 460 nM [21]
2-(p-Methylsulfonylbenzoyl)furan Drug Info IC50 = 15100 nM [25]
2-Phenyl-1,2-dihydro-indazol-3-one Drug Info IC50 = 2700 nM [3]
2-(2,3,4-trimethoxyphenyl)-1H-indene Drug Info IC50 = 30 nM [21]
Oxametacin Drug Info IC50 = 2800 nM [26]
N-(3-phenylamino-4-pyridinyl)methanesulfonamide Drug Info IC50 = 2260 nM [27]
N-(3-phenoxypyridin-4-yl)methanesulfonamide Drug Info IC50 = 410 nM [27]
2'-epi-guianin Drug Info IC50 = 18200 nM [28]
PHENIDONE Drug Info IC50 = 3000 nM [3]
5-Ethyl-3,4-diphenyl-isoxazole Drug Info IC50 = 50 nM [24]
3 beta-O-acetyloleanolic acid Drug Info IC50 = 1 nM [29]
(11H-Dibenzo[b,e][1,4]dioxepin-7-yl)-acetic acid Drug Info IC50 = 1400 nM [6]
5-(2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline Drug Info IC50 = 173 nM [30]
1,2-dihydro-3-(2,3,4-trimethoxyphenyl)naphthalene Drug Info IC50 = 480 nM [21]
1-(4-(methylsulfonyl)phenyl)-3-p-tolylurea Drug Info IC50 = 12500 nM [19]
Salicyclic acid Drug Info IC50 = 1700 nM [31]
IODOSUPROFEN Drug Info IC50 = 1000 nM [14]
Alpha-Methyl-4-biphenyl-acetic acid Drug Info IC50 = 110 nM [14]
N-(3-(phenylthio)pyridin-4-yl)methanesulfonamide Drug Info IC50 = 3620 nM [27]
TEBUFELONE Drug Info IC50 = 250 nM [32]
RESORCINOL Drug Info IC50 = 3600 nM [33]
(Z)-2'-des-methyl sulindac sulfide Drug Info IC50 = 375 nM [34]
4,5-Bis(4-chlorophenyl)-1,2-selenazole Drug Info IC50 = 200 nM [17]
METHYLHONOKIOL Drug Info IC50 = 100 nM [7]
4'-Methoxy-5,3'-dipropyl-biphenyl-2ol Drug Info IC50 = 7700 nM [7]
4,5-Bis(4-chlorophenyl)isothiazole Drug Info IC50 = 100 nM [16]
3-(4-Methanesulfonyl-phenyl)-1-phenyl-propynone Drug Info IC50 = 1000 nM [35]
SC-58451 Drug Info IC50 = 140 nM
Primary alcohol metabolite of celecoxib Drug Info IC50 = 7100 nM [36]
5-(4-Methoxyphenyl)-4-p-tolylisothiazole Drug Info IC50 = 10 nM [16]
2-(N-(2-fluorophenyl)pyrrol-2-yl) acetic acid Drug Info IC50 = 19800 nM [20]
Acetic acid 2-heptylsulfanyl-phenyl ester Drug Info IC50 = 6000 nM [12]
5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole Drug Info IC50 = 20 nM [17]
IMRECOXIB Drug Info IC50 = 115 nM [37]
FENBUFEN Drug Info IC50 = 3900 nM [38]
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