Drug General Information
Drug ID	D07STC
Former ID	DNC007772
Drug Name	2-(N-(2-fluorophenyl)pyrrol-2-yl) acetic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528854]
Structure		Download 2D MOL 3D MOL
Formula	C12H10FNO2
Canonical SMILES	C1=CC=C(C(=C1)N2C=CC=C2CC(=O)O)F
InChI	1S/C12H10FNO2/c13-10-5-1-2-6-11(10)14-7-3-4-9(14)8-12(15)16/h1-7H,8H2,(H,15,16)
InChIKey	XOJPIEDVJHMQEJ-UHFFFAOYSA-N
PubChem Compound ID	44434500
Target and Pathway
Target(s)	Prostaglandin G/H synthase 1	Target Info	Inhibitor	[528854]
	Prostaglandin G/H synthase 2	Target Info	Inhibitor	[528854]
BioCyc Pathway	C20 prostanoid biosynthesisPWY66-393:Aspirin-triggered lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	C20 prostanoid biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Platelet activation
	Serotonergic synapsehsa00590:Arachidonic acid metabolism
	NF-kappa B signaling pathway
	VEGF signaling pathway
	TNF signaling pathway
	Retrograde endocannabinoid signaling
	Serotonergic synapse
	Ovarian steroidogenesis
	Oxytocin signaling pathway
	Regulation of lipolysis in adipocytes
	Leishmaniasis
	Pathways in cancer
	Chemical carcinogenesis
	MicroRNAs in cancer
	Small cell lung cancer
NetPath Pathway	TGF_beta_Receptor Signaling PathwayNetPath_13:IL1 Signaling Pathway
	TSH Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL5 Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathwayP00019:Endothelin signaling pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Toll receptor signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	S1P1 pathway
	C-MYB transcription factor network
	Signaling mediated by p38-alpha and p38-beta
	Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway	Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Phase 1 - Functionalization of compounds
	Eicosanoid Synthesis
	Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
	Aryl Hydrocarbon Receptor
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Selenium Micronutrient Network
References
Ref 528854	Bioorg Med Chem. 2007 Jul 15;15(14):4876-90. Epub 2007 May 3.Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system.
Ref 528854	Bioorg Med Chem. 2007 Jul 15;15(14):4876-90. Epub 2007 May 3.Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system.

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