| Drug General Information |
| Drug ID |
D06WML
|
| Former ID |
DNC005239
|
| Drug Name |
5-Ethyl-3,4-diphenyl-isoxazole
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H15NO
|
| Canonical SMILES |
CCC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=CC=C3
|
| InChI |
1S/C17H15NO/c1-2-15-16(13-9-5-3-6-10-13)17(18-19-15)14-11-7-4-8-12-14/h3-12H,2H2,1H3
|
| InChIKey |
MXTWADCRLRQMDW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Prostaglandin G/H synthase 1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
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C20 prostanoid biosynthesisPWY66-393:Aspirin-triggered lipoxin biosynthesis
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Aspirin triggered resolvin D biosynthesis
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C20 prostanoid biosynthesis
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Aspirin triggered resolvin E biosynthesis
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KEGG Pathway
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Arachidonic acid metabolism
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Metabolic pathways
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Platelet activation
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Serotonergic synapsehsa00590:Arachidonic acid metabolism
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NF-kappa B signaling pathway
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VEGF signaling pathway
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TNF signaling pathway
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Retrograde endocannabinoid signaling
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Serotonergic synapse
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Ovarian steroidogenesis
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Oxytocin signaling pathway
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Regulation of lipolysis in adipocytes
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Leishmaniasis
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Pathways in cancer
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Chemical carcinogenesis
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MicroRNAs in cancer
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Small cell lung cancer
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NetPath Pathway
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TGF_beta_Receptor Signaling PathwayNetPath_13:IL1 Signaling Pathway
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TSH Signaling Pathway
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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IL5 Signaling Pathway
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PANTHER Pathway
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Inflammation mediated by chemokine and cytokine signaling pathwayP00019:Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Toll receptor signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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S1P1 pathway
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C-MYB transcription factor network
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Signaling mediated by p38-alpha and p38-beta
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Calcium signaling in the CD4+ TCR pathway
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PathWhiz Pathway
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Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
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WikiPathways
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Prostaglandin Synthesis and Regulation
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Arachidonic acid metabolism
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Phase 1 - Functionalization of compounds
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Eicosanoid Synthesis
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Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
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Aryl Hydrocarbon Receptor
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Selenium Micronutrient Network
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| References |
| REF 1 | J Med Chem. 2004 Sep 23;47(20):4881-90.Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. |
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