| Drug General Information |
| Drug ID |
D0T7BP
|
| Former ID |
DNC013494
|
| Drug Name |
1-(4-(methylsulfonyl)phenyl)-3-p-tolylurea
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H16N2O3S
|
| Canonical SMILES |
CC1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)S(=O)(=O)C
|
| InChI |
1S/C15H16N2O3S/c1-11-3-5-12(6-4-11)16-15(18)17-13-7-9-14(10-8-13)21(2,19)20/h3-10H,1-2H3,(H2,16,17,18)
|
| InChIKey |
ZWDYDUJTBVZZLR-UHFFFAOYSA-N
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| PubChem Compound ID |
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| Target and Pathway |
| Target(s) |
Prostaglandin G/H synthase 1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[1]
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BioCyc Pathway
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C20 prostanoid biosynthesisPWY66-393:Aspirin-triggered lipoxin biosynthesis
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Aspirin triggered resolvin D biosynthesis
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C20 prostanoid biosynthesis
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Aspirin triggered resolvin E biosynthesis
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KEGG Pathway
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Arachidonic acid metabolism
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Metabolic pathways
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Platelet activation
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Serotonergic synapsehsa00590:Arachidonic acid metabolism
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NF-kappa B signaling pathway
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VEGF signaling pathway
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TNF signaling pathway
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Retrograde endocannabinoid signaling
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Serotonergic synapse
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Ovarian steroidogenesis
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Oxytocin signaling pathway
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Regulation of lipolysis in adipocytes
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Leishmaniasis
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Pathways in cancer
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Chemical carcinogenesis
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MicroRNAs in cancer
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Small cell lung cancer
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NetPath Pathway
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TGF_beta_Receptor Signaling PathwayNetPath_13:IL1 Signaling Pathway
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TSH Signaling Pathway
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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IL5 Signaling Pathway
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PANTHER Pathway
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Inflammation mediated by chemokine and cytokine signaling pathwayP00019:Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Toll receptor signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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S1P1 pathway
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C-MYB transcription factor network
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Signaling mediated by p38-alpha and p38-beta
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Calcium signaling in the CD4+ TCR pathway
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PathWhiz Pathway
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Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
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WikiPathways
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Prostaglandin Synthesis and Regulation
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Arachidonic acid metabolism
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Phase 1 - Functionalization of compounds
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Eicosanoid Synthesis
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Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
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Aryl Hydrocarbon Receptor
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Selenium Micronutrient Network
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| References |
| REF 1 | Bioorg Med Chem Lett. 2008 Feb 15;18(4):1336-9. Epub 2008 Jan 11.Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors. |
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