| Drug General Information |
| Drug ID |
D09HWQ
|
| Former ID |
DNC012894
|
| Drug Name |
3-(4-Methanesulfonyl-phenyl)-1-phenyl-propynone
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H12O3S
|
| Canonical SMILES |
CS(=O)(=O)C1=CC=C(C=C1)C#CC(=O)C2=CC=CC=C2
|
| InChI |
1S/C16H12O3S/c1-20(18,19)15-10-7-13(8-11-15)9-12-16(17)14-5-3-2-4-6-14/h2-8,10-11H,1H3
|
| InChIKey |
OIHHELVXIPDXIK-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| Prostaglandin G/H synthase 1 |
Target Info |
Inhibitor |
[1]
|
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BioCyc Pathway
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Aspirin-triggered lipoxin biosynthesis
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Aspirin triggered resolvin D biosynthesis
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C20 prostanoid biosynthesis
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Aspirin triggered resolvin E biosynthesisPWY66-374:C20 prostanoid biosynthesis
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KEGG Pathway
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Arachidonic acid metabolism
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Metabolic pathways
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NF-kappa B signaling pathway
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VEGF signaling pathway
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TNF signaling pathway
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Retrograde endocannabinoid signaling
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Serotonergic synapse
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Ovarian steroidogenesis
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Oxytocin signaling pathway
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Regulation of lipolysis in adipocytes
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Leishmaniasis
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Pathways in cancer
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Chemical carcinogenesis
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MicroRNAs in cancer
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Small cell lung cancerhsa00590:Arachidonic acid metabolism
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Platelet activation
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NetPath Pathway
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IL1 Signaling Pathway
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TSH Signaling Pathway
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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IL5 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Toll receptor signaling pathway
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CCKR signaling map STP00031:Inflammation mediated by chemokine and cytokine signaling pathway
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Pathway Interaction Database
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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S1P1 pathway
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C-MYB transcription factor network
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Signaling mediated by p38-alpha and p38-beta
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Calcium signaling in the CD4+ TCR pathway
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PathWhiz Pathway
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Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
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WikiPathways
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Prostaglandin Synthesis and Regulation
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Arachidonic acid metabolism
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Aryl Hydrocarbon Receptor
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Eicosanoid Synthesis
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Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
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Phase 1 - Functionalization of compounds
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Selenium Micronutrient Network
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| References |
| REF 1 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4842-5.Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases. |
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