Drug General Information
Drug ID
D0N0UC
Former ID
DNC002438
Drug Name
Lauric Acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540924]
Structure
Download
2D MOL

3D MOL

Formula
C12H24O2
InChI
InChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
InChIKey
POULHZVOKOAJMA-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Toll-like receptor 4 Target Info Inhibitor [551393]
Genome polyprotein Target Info Inhibitor [551393]
Lymphocyte antigen 96 Target Info Inhibitor [551393]
Lactotransferrin Target Info Inhibitor [551393]
3-oxoacyl-[acyl-carrier-protein] synthase II Target Info Inhibitor [551393]
Phospholipase A2, membrane associated Target Info Inhibitor [551393]
3-oxoacyl-[acyl-carrier-protein] synthase 1 Target Info Inhibitor [551393]
Hepatocyte nuclear factor 4-alpha Target Info Inhibitor [551393]
BioCyc Pathway Phospholipases
KEGG Pathway NF-kappa B signaling pathway
HIF-1 signaling pathway
Phagosome
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Influenza A
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritishsa04064:NF-kappa B signaling pathway
Toxoplasmosishsa00564:Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorptionhsa04152:AMPK signaling pathway
Maturity onset diabetes of the young
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
IL6 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathwayP00054:Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signalingtoll_endogenous_pathway:Endogenous TLR signalingglypican_1pathway:Glypican 1 networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
FOXA2 and FOXA3 transcription factor networks
HIF-1-alpha transcription factor network
Reactome Ligand-dependent caspase activation
Toll Like Receptor 4 (TLR4) Cascade
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent TLR3/TLR4 cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6 mediated induction of TAK1 complexR-HSA-140534:Ligand-dependent caspase activation
TRAF6 mediated induction of TAK1 complexR-HSA-1222556:ROS production in response to bacteria
Amyloid formationR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PIR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
MyD88-independent cascade
Primary Focal Segmental Glomerulosclerosis FSGS
Spinal Cord Injury
Corticotropin-releasing hormone
Pathogenic Escherichia coli infection
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathwayWP2700:Latent infection of Homo sapiens with Mycobacterium tuberculosisWP2795:Cardiac Hypertrophic Response
Glycerophospholipid biosynthesis
Glycerophospholipid Biosynthetic Pathway
Eicosanoid Synthesis
MicroRNAs in cardiomyocyte hypertrophyWP2857:Mesodermal Commitment Pathway
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
AMPK Signaling
References
Ref 540924(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5534).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.