Target Information
Target General Infomation | |||||
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Target ID |
T82723
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Former ID |
TTDR00292
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Target Name |
3-oxoacyl-[acyl-carrier-protein] synthase II
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Gene Name |
fabF
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Synonyms |
3-oxoacyl-[acyl-carrier-protein] synthase 2; Beta-ketoacyl-ACP synthase 2; Beta-ketoacyl-ACP synthase II; Beta-ketoacyl-acyl carrier protein synthase B; Condensing enzyme FabF; FabF; KAS 2; KAS II; KASB; fabF
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Target Type |
Research
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Disease | Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99] | ||||
Malaria [ICD10: B54] | |||||
Function |
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis.
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BioChemical Class |
Acyltransferase
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UniProt ID | |||||
EC Number |
EC 2.3.1.41
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Sequence |
MSKRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCE
DIISRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHT SLMNGGPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAY GDADVMVAGGAEKASTPLGVGGFGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLV LEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGY VNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRD QAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI |
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References |
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