Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T82723
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| Former ID |
TTDR00292
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| Target Name |
3-oxoacyl-[acyl-carrier-protein] synthase II
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| Gene Name |
fabF
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| Synonyms |
3-oxoacyl-[acyl-carrier-protein] synthase 2; Beta-ketoacyl-ACP synthase 2; Beta-ketoacyl-ACP synthase II; Beta-ketoacyl-acyl carrier protein synthase B; Condensing enzyme FabF; FabF; KAS 2; KAS II; KASB; fabF
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| Target Type |
Research
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| Disease | Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99] | ||||
| Malaria [ICD10: B54] | |||||
| Function |
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis.
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| BioChemical Class |
Acyltransferase
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| UniProt ID | |||||
| EC Number |
EC 2.3.1.41
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| Sequence |
MSKRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCE
DIISRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHT SLMNGGPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAY GDADVMVAGGAEKASTPLGVGGFGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLV LEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGY VNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRD QAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI |
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| Inhibitor | Lauric Acid | Drug Info | [1] | ||
| PLATENSIMYCIN | Drug Info | [2] | |||
| Binder | Thiolactomycin | Drug Info | [3] | ||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
| REF 3 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
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