Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T15514
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| Former ID |
TTDR00269
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| Target Name |
Hepatocyte nuclear factor 4-alpha
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| Gene Name |
HNF4A
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| Synonyms |
HNF-4-alpha; Transcription factor 14; Transcription factor HNF-4; HNF4A
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| Target Type |
Research
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| Function |
Transcriptionally controlled transcription factor. Binds to dna sites required for the transcription of alpha 1- antitrypsin, apolipoprotein ciii, transthyretin genes and hnf1- alpha. May be essential for development of the liver, kidney and intestine.
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| BioChemical Class |
Nuclear hormone receptor
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| UniProt ID | |||||
| Sequence |
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC
AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI |
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| Antagonist | BI6015 | Drug Info | [1] | ||
| Inhibitor | Lauric Acid | Drug Info | [2] | ||
| MYRISTIC ACID | Drug Info | [3] | |||
| Pathways | |||||
| KEGG Pathway | AMPK signaling pathway | ||||
| Maturity onset diabetes of the young | |||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| FOXA2 and FOXA3 transcription factor networks | |||||
| HIF-1-alpha transcription factor network | |||||
| Reactome | Nuclear Receptor transcription pathway | ||||
| WikiPathways | Mesodermal Commitment Pathway | ||||
| Integrated Pancreatic Cancer Pathway | |||||
| Nuclear Receptors | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | HNF4alpha antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19(7):806-18. | ||||
| REF 2 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 3 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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