Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T52617
|
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| Former ID |
TTDR01245
|
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| Target Name |
3-oxoacyl-[acyl-carrier-protein] synthase 1
|
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| Gene Name |
kasA
|
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| Synonyms |
Beta-ketoacyl-ACP synthase 1; KAS 1; kasA
|
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| Target Type |
Research
|
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| Function |
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-acp (by similarity).
|
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| BioChemical Class |
Acyltransferase
|
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| UniProt ID | |||||
| EC Number |
EC 2.3.1.41
|
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| Sequence |
MSQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKI
GGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEVDPDRFAVVVGTGLGGAE RIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAH AWRQIVMGDADVAVCGGVEGPIEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG EAGALMLIETEEHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGL SPADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVGALESVLTVL TLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVALAFGRY |
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| Inhibitor | 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE | Drug Info | [1] | ||
| Caprylic acid | Drug Info | [2] | |||
| Decanoic Acid | Drug Info | [3] | |||
| Lauric Acid | Drug Info | [3] | |||
| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| References | |||||
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
| REF 2 | Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. | ||||
| REF 3 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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