Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T81443
|
||||
Former ID |
TTDC00209
|
||||
Target Name |
Toll-like receptor 4
|
||||
Gene Name |
TLR4
|
||||
Synonyms |
HToll; TLR-4; TLR4
|
||||
Target Type |
Clinical Trial
|
||||
Disease | Autoimmune diabetes [ICD10: E08-E13] | ||||
Allergy [ICD9: 995.3; ICD10: T78.4] | |||||
Cancer [ICD9: 140-229; ICD10: C00-C96] | |||||
Hepatitis virus infection [ICD9: 573.3; ICD10: K75.9] | |||||
Melanoma [ICD9: 172; ICD10: C43] | |||||
Prostate cancer [ICD9: 185; ICD10: C61] | |||||
Sepsis [ICD9: 995.91; ICD10: A40, A41] | |||||
Septic shock [ICD9: 785.52; ICD10: A41.9] | |||||
Function |
Cooperates with ly96 and cd14 to mediate the innate immune response to bacterial lipopolysaccharide (lps). Acts via myd88, tirap and traf6, leading to nf-kappa-b activation, cytokine secretion and the inflammatoryresponse.
|
||||
BioChemical Class |
Toll-like receptor family
|
||||
Target Validation |
T81443
|
||||
UniProt ID | |||||
Sequence |
MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI |
||||
Drugs and Mode of Action | |||||
Drug(s) | MPL-containing Pollinex allergy desensitization vaccine | Drug Info | Preregistration | Allergy | [546900] |
Cadi-05 | Drug Info | Phase 3 | Prostate cancer | [522525] | |
ERITORAN | Drug Info | Phase 3 | Septic shock | [468097], [521840] | |
Resatorvid | Drug Info | Phase 3 | Sepsis | [522254] | |
CRX-675 | Drug Info | Phase 1 | Hepatitis virus infection | [521583] | |
NI-0101 | Drug Info | Phase 1 | Autoimmune diabetes | [524234] | |
OM-174 | Drug Info | Phase 1 | Cancer | [524222] | |
CS-4771 | Drug Info | Discontinued in Phase 1 | Sepsis | [549092] | |
LZ-8 | Drug Info | Terminated | Autoimmune diabetes | [546038] | |
Inhibitor | 3-Hydroxy-Myristic Acid | Drug Info | [551393] | ||
6-(2-aminophenoxy)benzo[d]isothiazol-3-amine | Drug Info | [529731] | |||
CRX-526 | Drug Info | [529737] | |||
ERITORAN | Drug Info | [529731] | |||
Lauric Acid | Drug Info | [551393] | |||
MYRISTIC ACID | Drug Info | [551374] | |||
Modulator | AS04 | Drug Info | [543474] | ||
CS-4771 | Drug Info | [551205] | |||
LZ-8 | Drug Info | [543474] | |||
OM-174 | Drug Info | [532290] | |||
OM-197-MP-AC | Drug Info | [543474] | |||
OM-294-DP | Drug Info | [543474] | |||
Agonist | CRX-675 | Drug Info | [543474] | ||
Antagonist | Resatorvid | Drug Info | [536637], [551717], [551795] | ||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | NF-kappa B signaling pathway | ||||
HIF-1 signaling pathway | |||||
Phagosome | |||||
PI3K-Akt signaling pathway | |||||
Toll-like receptor signaling pathway | |||||
Pathogenic Escherichia coli infection | |||||
Salmonella infection | |||||
Pertussis | |||||
Legionellosis | |||||
Leishmaniasis | |||||
Chagas disease (American trypanosomiasis) | |||||
Malaria | |||||
Toxoplasmosis | |||||
Amoebiasis | |||||
Tuberculosis | |||||
Hepatitis B | |||||
Measles | |||||
Influenza A | |||||
Proteoglycans in cancer | |||||
Inflammatory bowel disease (IBD) | |||||
Rheumatoid arthritis | |||||
NetPath Pathway | IL5 Signaling Pathway | ||||
IL2 Signaling Pathway | |||||
IL4 Signaling Pathway | |||||
PANTHER Pathway | Toll receptor signaling pathway | ||||
Pathway Interaction Database | Endogenous TLR signaling | ||||
Reactome | Ligand-dependent caspase activation | ||||
Toll Like Receptor 4 (TLR4) Cascade | |||||
Mal cascade initiated on plasma membrane | |||||
MyD88-independent TLR3/TLR4 cascade | |||||
TRIF-mediated programmed cell death | |||||
MyD88 deficiency (TLR2/4) | |||||
IRAK4 deficiency (TLR2/4) | |||||
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | |||||
IKK complex recruitment mediated by RIP1 | |||||
TRAF6 mediated induction of TAK1 complex | |||||
WikiPathways | Toll-like receptor signaling pathway | ||||
Toll-Like Receptors Cascades | |||||
Mal cascade initiated on plasma membrane | |||||
MyD88-independent cascade | |||||
Primary Focal Segmental Glomerulosclerosis FSGS | |||||
Spinal Cord Injury | |||||
Corticotropin-releasing hormone | |||||
Pathogenic Escherichia coli infection | |||||
Regulation of toll-like receptor signaling pathway | |||||
References | |||||
Ref 468097 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4919). | ||||
Ref 521583 | ClinicalTrials.gov (NCT00076037) Safety of and Immune Response to a New HIV Vaccine: HIV CTL MEP. U.S. National Institutes of Health. | ||||
Ref 521840 | ClinicalTrials.gov (NCT00334828) ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis. U.S. National Institutes of Health. | ||||
Ref 522254 | ClinicalTrials.gov (NCT00633477) Efficacy and Safety of Resatorvid in Patients With Sepsis-induced Cardiovascular and Respiratory Failure. U.S. National Institutes of Health. | ||||
Ref 522525 | ClinicalTrials.gov (NCT00810849) A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis. U.S. National Institutes of Health. | ||||
Ref 524222 | ClinicalTrials.gov (NCT01800812) Effects of OM-174 in Adult Patients With Solid Tumors. U.S. National Institutes of Health. | ||||
Ref 524234 | ClinicalTrials.gov (NCT01808469) First in Human Study of an Anti-Toll-like Receptor 4 (TLR4) Monoclonal Antibody (NI-0101) in Adult Healthy Volunteers. U.S. National Institutes of Health. | ||||
Ref 546038 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006001) | ||||
Ref 529731 | J Med Chem. 2008 Nov 13;51(21):6621-6. Epub 2008 Oct 2.Small molecule modulators of toll-like receptors. | ||||
Ref 529737 | Bioorg Med Chem Lett. 2008 Oct 15;18(20):5350-4. Epub 2008 Sep 19.The 'Ethereal' nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics. | ||||
Ref 532273 | Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL). Biomed Res Int. 2013;2013:976383. | ||||
Ref 532290 | Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. BMC Cancer. 2013 Apr 2;13:172. | ||||
Ref 536637 | TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol. 2008 Apr 14;584(1):40-8. Epub 2008 Feb 5. | ||||
Ref 543474 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754). | ||||
Ref 544251 | Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716. | ||||
Ref 550003 | Allergy Therapeutics PLC. News Announcement. Allergy Therapeutics. Clinical Trials. Allergy Therapeutics PLC. 11 October 2006. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.