Drug Information
Drug General Information | |||||
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Drug ID |
D0E4GG
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Former ID |
DCL000620
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Drug Name |
Resatorvid
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Drug Type |
Small molecular drug
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Indication | Sepsis [ICD9: 995.91; ICD10:A40, A41] | Phase 3 | [522254] | ||
Company |
Takeda
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Structure |
Download2D MOL |
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Formula |
C15H17ClFNO4S
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Canonical SMILES |
CCOC(=O)C1=CCCCC1S(=O)(=O)NC2=C(C=C(C=C2)F)Cl
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InChI |
1S/C15H17ClFNO4S/c1-2-22-15(19)11-5-3-4-6-14(11)23(20,21)18-13-8-7-10(17)9-12(13)16/h5,7-9,14,18H,2-4,6H2,1H3/t14-/m1/s1
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InChIKey |
LEEIJTHMHDMWLJ-CQSZACIVSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Toll-like receptor 4 | Target Info | Antagonist | [536637], [551717], [551795] | |
KEGG Pathway | NF-kappa B signaling pathway | ||||
HIF-1 signaling pathway | |||||
Phagosome | |||||
PI3K-Akt signaling pathway | |||||
Toll-like receptor signaling pathway | |||||
Pathogenic Escherichia coli infection | |||||
Salmonella infection | |||||
Pertussis | |||||
Legionellosis | |||||
Leishmaniasis | |||||
Chagas disease (American trypanosomiasis) | |||||
Malaria | |||||
Toxoplasmosis | |||||
Amoebiasis | |||||
Tuberculosis | |||||
Hepatitis B | |||||
Measles | |||||
Influenza A | |||||
Proteoglycans in cancer | |||||
Inflammatory bowel disease (IBD) | |||||
Rheumatoid arthritis | |||||
PANTHER Pathway | Toll receptor signaling pathway | ||||
Pathway Interaction Database | Endogenous TLR signaling | ||||
Reactome | Ligand-dependent caspase activation | ||||
Toll Like Receptor 4 (TLR4) Cascade | |||||
MyD88:Mal cascade initiated on plasma membrane | |||||
MyD88-independent TLR3/TLR4 cascade | |||||
TRIF-mediated programmed cell death | |||||
MyD88 deficiency (TLR2/4) | |||||
IRAK4 deficiency (TLR2/4) | |||||
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | |||||
IKK complex recruitment mediated by RIP1 | |||||
TRAF6 mediated induction of TAK1 complex | |||||
WikiPathways | Toll-like receptor signaling pathway | ||||
Toll-Like Receptors Cascades | |||||
MyD88:Mal cascade initiated on plasma membrane | |||||
MyD88-independent cascade | |||||
Primary Focal Segmental Glomerulosclerosis FSGS | |||||
Spinal Cord Injury | |||||
Corticotropin-releasing hormone | |||||
Pathogenic Escherichia coli infection | |||||
Regulation of toll-like receptor signaling pathway | |||||
References | |||||
Ref 536637 | TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol. 2008 Apr 14;584(1):40-8. Epub 2008 Feb 5. | ||||
Ref 551717 | Clinical pipeline report, company report or official report of Takeda (2009). | ||||
Ref 551795 | THE NOVEL SELECTIVE TOLL-LIKE RECEPTOR 4 SIGNAL TRANSDUCTION INHIBITOR TAK-242 PREVENTS ENDOTOXAEMIA IN CONSCIOUS GUINEA-PIGS. Clinical and Experimental Pharmacology and Physiology Volume 36, Issue 5-6, pages 589-593, May/June 2009 |
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