Drug Information
Drug General Information | |||||
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Drug ID |
D0SJ8Q
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Former ID |
DNC009286
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Drug Name |
ERITORAN
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C66H126N2O19P2
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InChI |
InChI=1S/C66H126N2O19P2/c1-7-11-15-19-22-25-26-27-28-29-30-32-34-38-42-46-57(70)67-60-64(82-49-47-54(80-6)45-41-36-18-14-10-4)62(86-88(73,74)75)56(51-79-5)85-65(60)83-52-55-61(72)63(81-48-43-39-35-24-21-17-13-9-3)59(66(84-55)87-89(76,77)78)68-58(71)50-53(69)44-40-37-33-31-23-20-16-12-8-2/h25-26,54-56,59-66,72H,7-24,27-52H2,1-6H3,(H,67,70)(H,68,71)(H2,73,74,75)(H2,76,77,78)/b26-25-/t54-,55-,56-,59-,60-,61-,62-,63-,64-,65-,66-/m1/s1
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InChIKey |
BPSMYQFMCXXNPC-MFCPCZTFSA-N
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CAS Number |
CAS 185955-34-4
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Toll-like receptor 4 | Target Info | Inhibitor | [529731] | |
KEGG Pathway | NF-kappa B signaling pathway | ||||
HIF-1 signaling pathway | |||||
Phagosome | |||||
PI3K-Akt signaling pathway | |||||
Toll-like receptor signaling pathway | |||||
Pathogenic Escherichia coli infection | |||||
Salmonella infection | |||||
Pertussis | |||||
Legionellosis | |||||
Leishmaniasis | |||||
Chagas disease (American trypanosomiasis) | |||||
Malaria | |||||
Toxoplasmosis | |||||
Amoebiasis | |||||
Tuberculosis | |||||
Hepatitis B | |||||
Measles | |||||
Influenza A | |||||
Proteoglycans in cancer | |||||
Inflammatory bowel disease (IBD) | |||||
Rheumatoid arthritis | |||||
PANTHER Pathway | Toll receptor signaling pathway | ||||
Pathway Interaction Database | Endogenous TLR signaling | ||||
Reactome | Ligand-dependent caspase activation | ||||
Toll Like Receptor 4 (TLR4) Cascade | |||||
MyD88:Mal cascade initiated on plasma membrane | |||||
MyD88-independent TLR3/TLR4 cascade | |||||
TRIF-mediated programmed cell death | |||||
MyD88 deficiency (TLR2/4) | |||||
IRAK4 deficiency (TLR2/4) | |||||
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | |||||
IKK complex recruitment mediated by RIP1 | |||||
TRAF6 mediated induction of TAK1 complex | |||||
WikiPathways | Toll-like receptor signaling pathway | ||||
Toll-Like Receptors Cascades | |||||
MyD88:Mal cascade initiated on plasma membrane | |||||
MyD88-independent cascade | |||||
Primary Focal Segmental Glomerulosclerosis FSGS | |||||
Spinal Cord Injury | |||||
Corticotropin-releasing hormone | |||||
Pathogenic Escherichia coli infection | |||||
Regulation of toll-like receptor signaling pathway | |||||
References | |||||
Ref 468097 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4919). | ||||
Ref 521840 | ClinicalTrials.gov (NCT00334828) ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis. U.S. National Institutes of Health. |
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