Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T52382
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| Former ID |
TTDR00927
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| Target Name |
Lymphocyte antigen 96
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| Gene Name |
LY96
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| Synonyms |
ESOP-1; MD-2; MD-2 protein; LY96
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| Target Type |
Research
|
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| Function |
Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.
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| UniProt ID | |||||
| Sequence |
MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGL
LHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFS FKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN |
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| Inhibitor | 3-Hydroxy-Myristic Acid | Drug Info | [1] | ||
| Lauric Acid | Drug Info | [1] | |||
| MYRISTIC ACID | Drug Info | [2] | |||
| Pathways | |||||
| KEGG Pathway | NF-kappa B signaling pathway | ||||
| Toll-like receptor signaling pathway | |||||
| Pathogenic Escherichia coli infection | |||||
| Pertussis | |||||
| Toxoplasmosis | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| IL6 Signaling Pathway | |||||
| PANTHER Pathway | Toll receptor signaling pathway | ||||
| Pathway Interaction Database | Endogenous TLR signaling | ||||
| Reactome | Ligand-dependent caspase activation | ||||
| Toll Like Receptor 4 (TLR4) Cascade | |||||
| Mal cascade initiated on plasma membrane | |||||
| MyD88-independent TLR3/TLR4 cascade | |||||
| TRIF-mediated programmed cell death | |||||
| MyD88 deficiency (TLR2/4) | |||||
| IRAK4 deficiency (TLR2/4) | |||||
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | |||||
| IKK complex recruitment mediated by RIP1 | |||||
| TRAF6 mediated induction of TAK1 complex | |||||
| WikiPathways | Toll-like receptor signaling pathway | ||||
| Toll-Like Receptors Cascades | |||||
| Mal cascade initiated on plasma membrane | |||||
| MyD88-independent cascade | |||||
| Pathogenic Escherichia coli infection | |||||
| Regulation of toll-like receptor signaling pathway | |||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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