| Drug General Information |
| Drug ID |
D0A1DU
|
| Former ID |
DNC002503
|
| Drug Name |
Pyrophosphate 2-
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
H2O7P2-2
|
| Canonical SMILES |
OP(=O)([O-])OP(=O)(O)[O-]
|
| InChI |
1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-2
|
| InChIKey |
XPPKVPWEQAFLFU-UHFFFAOYSA-L
|
| PubChem Compound ID |
|
| PubChem Substance ID |
7437608, 7889993, 26697122, 29224068, 46508771, 80399921, 104307977, 124955076, 126408044, 137801774, 160965419
|
| Target and Pathway |
| Target(s) |
NH(3)-dependentNAD(+) synthetase |
Target Info |
Inhibitor |
[1]
|
|---|
| RNA-dependentRNA polymerase |
Target Info |
Inhibitor |
[1]
|
| Hypoxanthine-guanine-xanthine phosphoribosyltransferase |
Target Info |
Inhibitor |
[1]
|
| 6-phosphogluconate dehydrogenase, decarboxylating |
Target Info |
Inhibitor |
[1]
|
| Angiogenin |
Target Info |
Inhibitor |
[1]
|
| Hypoxanthine-guanine phosphoribosyltransferase |
Target Info |
Inhibitor |
[1]
|
| GMP synthase [glutamine-hydrolyzing] |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Pentose phosphate pathway
|
|
Pentose phosphate pathway (oxidative branch)PWY-7228:Guanosine nucleotides de novo biosynthesis
|
|
Superpathway of purine nucleotide salvage
|
|
Purine nucleotides de novo biosynthesis
|
|
Guanosine ribonucleotides de novo biosynthesis
|
|
KEGG Pathway
|
Pentose phosphate pathway
|
|
Glutathione metabolism
|
|
Metabolic pathways
|
|
Biosynthesis of antibiotics
|
|
Carbon metabolismhsa00230:Purine metabolism
|
|
Drug metabolism - other enzymes
|
|
Metabolic pathwayshsa00230:Purine metabolism
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
TGF_beta_Receptor Signaling Pathway
|
|
PANTHER Pathway
|
Pentose phosphate pathwayP02738:De novo purine biosynthesis
|
|
PathWhiz Pathway
|
Warburg EffectPW000052:Purine MetabolismPW000003:Glutamate Metabolism
|
|
Purine Metabolism
|
|
Reactome
|
Adherens junctions interactionsR-HSA-74217:Purine salvageR-HSA-73817:Purine ribonucleoside monophosphate biosynthesis
|
|
WikiPathways
|
NRF2 pathway
|
|
Nuclear Receptors Meta-Pathway
|
|
Metabolism of carbohydrates
|
|
Pentose Phosphate PathwayWP404:Nucleotide Metabolism
|
|
Mesodermal Commitment Pathway
|
|
Endoderm Differentiation
|
|
Metabolism of nucleotidesWP1851:Metabolism of nucleotides
|
| References |
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
|---|
