Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T51843
|
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| Former ID |
TTDC00001
|
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| Target Name |
RNA-dependentRNA polymerase
|
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| Synonyms |
NI-b; NIb; NS5B; Nonstructuralprotein 5b; Nuclear inclusion protein B; P66; P70; RNA-directed RNA polymerase; RdRp; Virus-encodednonstructural protein 5B
|
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| Target Type |
Discontinued
|
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| Disease | Viral infections [ICD9: 054.0, 054.1, 054.2, 054.3, 075, 771.2, 052, 053; ICD10: B01, B02, A60, B00, B27, G05.1, P35.2] | ||||
| BioChemical Class |
Kinase
|
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| Target Validation |
T51843
|
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| EC Number |
EC 2.7.7.48
|
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| Drugs and Mode of Action | |||||
| Drug(s) | Flutimide | Drug Info | Terminated | Discovery agent | [1] |
| Inhibitor | FdG | Drug Info | [2], [3], [4] | ||
| Flutimide | Drug Info | [2], [3], [4] | |||
| Guanosine-5'-Triphosphate | Drug Info | [5] | |||
| Pyrimidinyl acylthiourea | Drug Info | [2], [3], [4] | |||
| Pyrophosphate 2- | Drug Info | [6] | |||
| T-1105 | Drug Info | [2], [3], [4] | |||
| T-1106 | Drug Info | [2], [3], [4] | |||
| Thiadiazolo[2,3-a]pyrimidine | Drug Info | [2], [3], [4] | |||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006184) | ||||
| REF 2 | Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. | ||||
| REF 3 | PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral Res. 2008 Jun;78(3):194-201. Epub 2008 Jan 17. | ||||
| REF 4 | Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. Epub 2008 Oct 27. | ||||
| REF 5 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 6 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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