Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Q2ML
|
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| Former ID |
DNC000657
|
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| Drug Name |
Flutimide
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C12H18N2O3
|
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| Canonical SMILES |
CC(C)CC1=NC(=CC(C)C)C(=O)N(C1=O)O
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| InChI |
1S/C12H18N2O3/c1-7(2)5-9-11(15)14(17)12(16)10(13-9)6-8(3)4/h5,7-8,17H,6H2,1-4H3/b9-5-
|
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| InChIKey |
SIXHCCPAJIVTOY-UITAMQMPSA-N
|
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| CAS Number |
CAS 162666-34-4
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | CAP-dependent endonuclease | Target Info | Inhibitor | [2] | |
| RNA-dependentRNA polymerase | Target Info | Inhibitor | [3], [4], [5] | ||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006184) | ||||
| REF 2 | Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. J Org Chem. 2001 Aug 10;66(16):5504-16. | ||||
| REF 3 | Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. | ||||
| REF 4 | PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral Res. 2008 Jun;78(3):194-201. Epub 2008 Jan 17. | ||||
| REF 5 | Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. Epub 2008 Oct 27. | ||||
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