Drug General Information
Drug ID	D0Q2ML
Former ID	DNC000657
Drug Name	Flutimide
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[546072]
Structure		Download 2D MOL 3D MOL
Formula	C12H18N2O3
Canonical SMILES	CC(C)CC1=NC(=CC(C)C)C(=O)N(C1=O)O
InChI	1S/C12H18N2O3/c1-7(2)5-9-11(15)14(17)12(16)10(13-9)6-8(3)4/h5,7-8,17H,6H2,1-4H3/b9-5-
InChIKey	SIXHCCPAJIVTOY-UITAMQMPSA-N
CAS Number	CAS 162666-34-4
PubChem Compound ID	6443207
PubChem Substance ID	811641, 11969039, 14847386, 43035735, 51449023, 57369372, 103179857, 114567661, 134339021, 134340028, 135165866
Target and Pathway
Target(s)	CAP-dependent endonuclease	Target Info	Inhibitor	[535228]
	RNA-dependentRNA polymerase	Target Info	Inhibitor	[536317], [536620], [536903]
References
Ref 546072	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006184)
Ref 535228	Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. J Org Chem. 2001 Aug 10;66(16):5504-16.
Ref 536317	Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
Ref 536620	PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral Res. 2008 Jun;78(3):194-201. Epub 2008 Jan 17.
Ref 536903	Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. Epub 2008 Oct 27.

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