Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ZU6O
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| Former ID |
DNC001401
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| Drug Name |
T-1106
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| Drug Type |
Small molecular drug
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| Indication | Viral infections [ICD9: 054.0, 054.1, 054.2, 054.3, 075, 771.2, 052, 053; ICD10:B01, B02, A60, B00, B27, G05.1, P35.2] | Investigative | [1], [2], [3] | ||
| Structure |
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Download2D MOL |
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| Formula |
C10H13N3O6
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| Canonical SMILES |
C1=CN(C(=O)C(=N1)C(=O)N)C2C(C(C(O2)CO)O)O
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| InChI |
1S/C10H13N3O6/c11-8(17)5-9(18)13(2-1-12-5)10-7(16)6(15)4(3-14)19-10/h1-2,4,6-7,10,14-16H,3H2,(H2,11,17)/t4-,6-,7-,10-/m1/s1
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| InChIKey |
XVXWUBIIHFDOJO-KQYNXXCUSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | RNA-dependentRNA polymerase | Target Info | Inhibitor | [1], [2], [3] | |
| References | |||||
| REF 1 | Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. | ||||
| REF 2 | PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral Res. 2008 Jun;78(3):194-201. Epub 2008 Jan 17. | ||||
| REF 3 | Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. Epub 2008 Oct 27. | ||||
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