Target Information
Target General Infomation | |||||
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Target ID |
T80070
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Former ID |
TTDR00618
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Target Name |
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
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Gene Name |
LACZ
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Synonyms |
HGPRT; HGXPRT; HGXPRTase; LACZ
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Target Type |
Research
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Function |
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
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BioChemical Class |
Pentosyltransferase
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UniProt ID | |||||
EC Number |
EC 2.4.2.-
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Sequence |
MPIPNNPGAGENAFDPVFVKDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYD
IKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVEMSKPLFGEHYVRVKSYCNDQ STGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPL WNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL |
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References |
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