Target General Infomation
Target ID
T80070
Former ID
TTDR00618
Target Name
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Gene Name
LACZ
Synonyms
HGPRT; HGXPRT; HGXPRTase; LACZ
Target Type
Research
Function
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
BioChemical Class
Pentosyltransferase
UniProt ID
EC Number
EC 2.4.2.-
Sequence
MPIPNNPGAGENAFDPVFVKDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYD
IKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVEMSKPLFGEHYVRVKSYCNDQ
STGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPL
WNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
Inhibitor Pyrophosphate 2- Drug Info [551374]
References
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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