Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T75517
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| Former ID |
TTDR00774
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| Target Name |
GMP synthase [glutamine-hydrolyzing]
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| Gene Name |
GMPS
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| Synonyms |
GMP synthetase; Glutamine amidotransferase; GMPS
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| Target Type |
Research
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| Function |
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
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| BioChemical Class |
Carbon-nitrogen ligase
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| UniProt ID | |||||
| EC Number |
EC 6.3.5.2
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| Sequence |
MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP
AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHK KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE SKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVL VLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA HSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPE EVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVR ILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPH TLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDW ESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILR ESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVE VVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE |
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| Inhibitor | 2,3,4-tribromo-6-(2,4-dibromophenoxy)phenol | Drug Info | [1] | ||
| 3,4,5-tribromo-2-(2', 4'-dibromo-phenoxy)phenol | Drug Info | [1] | |||
| 3,5-dibromo-2-(2,4-dibromophenoxy)phenol | Drug Info | [1] | |||
| Decoyinine | Drug Info | [2] | |||
| Pyrophosphate 2- | Drug Info | [3] | |||
| Pathways | |||||
| BioCyc Pathway | Guanosine nucleotides de novo biosynthesis | ||||
| Superpathway of purine nucleotide salvage | |||||
| Purine nucleotides de novo biosynthesis | |||||
| Guanosine ribonucleotides de novo biosynthesis | |||||
| KEGG Pathway | Purine metabolism | ||||
| Drug metabolism - other enzymes | |||||
| Metabolic pathways | |||||
| PANTHER Pathway | De novo purine biosynthesis | ||||
| PathWhiz Pathway | Glutamate Metabolism | ||||
| Purine Metabolism | |||||
| Reactome | Purine ribonucleoside monophosphate biosynthesis | ||||
| WikiPathways | Metabolism of nucleotides | ||||
| References | |||||
| REF 1 | Enzyme inhibitors: new and known polybrominated phenols and diphenyl ethers from four Indo-Pacific Dysidea sponges. J Nat Prod. 1995 Sep;58(9):1384-91. | ||||
| REF 2 | High-level production from a baculovirus expression system and biochemical characterization of human GMP synthetase. Protein Expr Purif. 1995 Aug;6(4):487-95. | ||||
| REF 3 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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