Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T76497
|
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| Former ID |
TTDR00910
|
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| Target Name |
6-phosphogluconate dehydrogenase, decarboxylating
|
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| Gene Name |
PGD
|
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| Synonyms |
6-phosphogluconate dehydrogenase; 6PGDH; PGD
|
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| Target Type |
Research
|
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| Function |
Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
|
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| BioChemical Class |
Short-chain dehydrogenases reductases
|
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| Target Validation |
T76497
|
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| UniProt ID | |||||
| EC Number |
EC 1.1.1.44
|
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| Sequence |
MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKE
MVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG ILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAG HFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANIL KFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQA SKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIAL MWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPM PCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSS YNA |
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| Inhibitor | (2R)-2-Methyl-4,5-dideoxy | Drug Info | [1] | ||
| (2R)-2-methyl-4-deoxy and 2,4-dideoxy | Drug Info | [1] | |||
| 4-phospho-D-erythronate | Drug Info | [2] | |||
| 5-deoxy-5-phosphono-D-arabinonate | Drug Info | [3] | |||
| 6-Phosphogluconic Acid | Drug Info | [4] | |||
| Pyrophosphate 2- | Drug Info | [5] | |||
| Pathways | |||||
| BioCyc Pathway | Pentose phosphate pathway | ||||
| Pentose phosphate pathway (oxidative branch) | |||||
| KEGG Pathway | Pentose phosphate pathway | ||||
| Glutathione metabolism | |||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| Carbon metabolism | |||||
| PANTHER Pathway | Pentose phosphate pathway | ||||
| PathWhiz Pathway | Warburg Effect | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Metabolism of carbohydrates | |||||
| Pentose Phosphate Pathway | |||||
| References | |||||
| REF 1 | Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14. | ||||
| REF 2 | Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem. 2010 Jul 15;18(14):5056-62. doi: 10.1016/j.bmc.2010.05.077. Epub 2010 Jun 9. | ||||
| REF 3 | Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14. | ||||
| REF 4 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 5 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
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